Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bentea, Eduard Mihai"'
Autor:
Massie, Ann, Verbruggen, Lise, Lara, Olaya, De Munck, Jolien, Janssen, Pauline, De Pauw, Laura, Hideyo, Sato, Ates, Gamze, Njemini, Rose, Kobayashi, Sho, Aerts, Joeri, Bentea, Eduard Mihai
The cystine/glutamate antiporter, with xCT as specific subunit, is mainly expressed in the central nervous system and tissues related to the immune system. Although system xc- has been proposed as therapeutic target for the treatment of cancer as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::5679fa795e4bcd5b3cab8305863e6baa
https://biblio.vub.ac.be/vubir/03219-system-xc--deficiency-extends-lifespan-and-modulates-aging-of-the-immune-system-in-mice(35e21949-30a6-4603-998a-bbc55b21f1aa).html
https://biblio.vub.ac.be/vubir/03219-system-xc--deficiency-extends-lifespan-and-modulates-aging-of-the-immune-system-in-mice(35e21949-30a6-4603-998a-bbc55b21f1aa).html
Autor:
Verbruggen, Lise, Bentea, Eduard Mihai, Villers, Agnès, Lara, Olaya, Ates, Gamze, De Bundel, Dimitri, Sato, Hideyo, Ris, Laurence, Massie, Ann
System xc-, with xCT as specific subunit, is an astrocytic antiporter that imports cystine in exchange for glutamate. System xc- is enhanced following oxidative stress and inflammation, both present in the aged brain. While we could not detect change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::cbeed2502850b36b0bae69d07846aadc
https://biblio.vub.ac.be/vubir/03218-system-xcdeficiency-prevents-agerelated-hippocampal-dysfunction-in-mice(e41ef267-621f-419a-b036-2d080b152a5b).html
https://biblio.vub.ac.be/vubir/03218-system-xcdeficiency-prevents-agerelated-hippocampal-dysfunction-in-mice(e41ef267-621f-419a-b036-2d080b152a5b).html
Autor:
Bentea, Eduard Mihai, Moore, Cynthia, Villers, Agnès, Churchill, Madeline J, Hood, Rebecca, Deneyer, Lauren, Verbruggen, Lise, Albertini, Giulia, Hideyo, Sato, Ris, Laurence, Meshul, Charles, Massie, Ann
System xc- is a plasma membrane amino acid antiporter, of mainly glial origin, that couples the import of cystine with the export of glutamate. System xc- (specific subunit xCT) contributes substantially to ambient extracellular glutamate levels in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::141ac07061b117bf9e454c8fb77c52a0
https://biblio.vub.ac.be/vubir/system-xc-as-a-novel-modulator-of-corticostriatal-neurotransmission(f4234e73-d8c9-4ee1-908b-5621c3590038).html
https://biblio.vub.ac.be/vubir/system-xc-as-a-novel-modulator-of-corticostriatal-neurotransmission(f4234e73-d8c9-4ee1-908b-5621c3590038).html
Neuroinflammation is a common feature in the pathogenesis of Parkinson's disease (PD), together with - among others - oxidative stress, proteasomal and mitochondrial dysfunction. Peripheral inflammation-induced microglial activation has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::90a7ca745a871438a1e91400d8dadb89
https://biblio.vub.ac.be/vubir/c054--peripheral-lpsinduced-inflammation-increases-the-susceptibility-for-proteasome-inhibitioninduced-degeneration-of-the-nigrostriatal-pathway(3b7e92bb-38e6-4a9a-89fa-34a9ab4364dc).html
https://biblio.vub.ac.be/vubir/c054--peripheral-lpsinduced-inflammation-increases-the-susceptibility-for-proteasome-inhibitioninduced-degeneration-of-the-nigrostriatal-pathway(3b7e92bb-38e6-4a9a-89fa-34a9ab4364dc).html
Autor:
Verbruggen, Lise, Bentea, Eduard Mihai, Deneyer, Lauren, Albertini, Giulia, Sato, Hideyo, Massie, Ann
Aim: We recently proposed the cystine-glutamate antiporter system xc-as a potential neuroprotective target in Parkinson’s disease (PD), an age-related neurodegenerative disorder. System xc- is an important source of extrasynaptic glutamate and is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::615f0bb4091931447c4b748c1a793da8
https://biblio.vub.ac.be/vubir/c054--loss-of-system-xc-protects-against-proteasomal-inhibitioninduced-neurodegeneration-in-aged-mice(d9f89f9b-6918-4b0e-a91b-143e55647a8a).html
https://biblio.vub.ac.be/vubir/c054--loss-of-system-xc-protects-against-proteasomal-inhibitioninduced-neurodegeneration-in-aged-mice(d9f89f9b-6918-4b0e-a91b-143e55647a8a).html
Autor:
Sprimont, Lindsay, Janssen, Pauline, De Swert, Kathleen, Gilloteaux, Jacques, Bouchat, Joanna, Verbruggen, Lise, Bentea, Eduard Mihai, Massie, Ann, Nicaise, Charles
xCT protein is the specific subunit of System xc-, a multi-proteic complex importing cystine into cell while releasing extracellular glutamate. Although xCT protein expression is detected in brain glial cells, its expression in the spinal cord and du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::a213152b567543465286e9225a449da3
https://biblio.vub.ac.be/vubir/c113--xctslc7a11-deletion-accelerates-functional-recovery-and-improves-histological-outcomes-following-cervical-spinal-contusion-in-mice(d12206c4-db5b-4f96-9210-64d255eea27c).html
https://biblio.vub.ac.be/vubir/c113--xctslc7a11-deletion-accelerates-functional-recovery-and-improves-histological-outcomes-following-cervical-spinal-contusion-in-mice(d12206c4-db5b-4f96-9210-64d255eea27c).html
Autor:
Massie, Ann, Bentea, Eduard Mihai, MOORE, C., CHURCHILL, M.J., HOOD, R.L., Deneyer, Lauren, Verbruggen, Lise, Hideyo, Sato, Meshul, Charles K
System xc- is a plasma membrane amino acid antiporter, of mainly glial origin, that couples the import of cystine with the export of glutamate. System xc- (specific subunit xCT) contributes substantially to ambient extracellular glutamate levels in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::bb31110d5fbe920694cb40220f90c860
https://biblio.vub.ac.be/vubir/pre-and-postsynaptic-changes-at-excitatory-synapses-in-xct-deficient-mice(a6fdd353-5a2d-4f52-a8a2-0390e101a4b6).html
https://biblio.vub.ac.be/vubir/pre-and-postsynaptic-changes-at-excitatory-synapses-in-xct-deficient-mice(a6fdd353-5a2d-4f52-a8a2-0390e101a4b6).html
Autor:
Albertini, Giulia, Deneyer, Lauren, Aourz, Najat, Bentea, Eduard Mihai, Demuyser, Thomas, Verbruggen, Lise, Hideyo, Sato, De Bundel, Dimitri, Massie, Ann, Smolders, Ilse
A variety of pathological stimuli is able to induce systemic inflammation. When systemic inflammation occurs, soluble mediators released from peripheral immune cells are able to reach the central nervous system (CNS) leading to defective brain homeos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::4e8ffa096a742b07bd1ab5859c163cff
https://biblio.vub.ac.be/vubir/clinical-and-central-outcomes-of-peripheral-inflammation-what-is-the-role-of-system-xc(5307e540-fd16-4341-a98a-e613201eea7b).html
https://biblio.vub.ac.be/vubir/clinical-and-central-outcomes-of-peripheral-inflammation-what-is-the-role-of-system-xc(5307e540-fd16-4341-a98a-e613201eea7b).html
Autor:
Bentea, Eduard Mihai, Van Liefferinge, Joeri, Demuyser, Thomas, Kobayashi, Sho, Deneyer, Lauren, Albertini, Giulia, Merckx, Ellen, Maes, Katrien, Hideyo, Sato, Smolders, Ilse Julia, Lewerenz, Jan, Massie, Ann
Zonisamide (ZNS), an anti-epileptic drug used in the symptomatic treatment of Parkinson’s disease (PD), has been recently linked with neuroprotective properties in toxin- and genetic-based models of PD. One of the mechanisms proposed to mediate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::11c84d0edbf3054c5919352ba839a601
https://biblio.vub.ac.be/vubir/poster-neuroprotective-effects-of-zonisamide-against-lactacystininduced-neurodegeneration-do-not-involve-changes-in-system-xc-expression(bb6e66ca-1c83-4ee4-91cf-a46f4f56645a).html
https://biblio.vub.ac.be/vubir/poster-neuroprotective-effects-of-zonisamide-against-lactacystininduced-neurodegeneration-do-not-involve-changes-in-system-xc-expression(bb6e66ca-1c83-4ee4-91cf-a46f4f56645a).html
Autor:
Bentea, Eduard Mihai, Deneyer, Lauren, Sconce, Michelle D, Churchill, Madeline J, Hood, Rebecca, Van Liefferinge, Joeri, Albertini, Giulia, Demuyser, Thomas, Merckx, Ellen, Smolders, Ilse Julia, Meshul, Charles, Massie, Ann
In Parkinson's disease (PD), the progressive degeneration of the nigrostriatal dopamine (DA) pathway leads to loss of striatal DA content, dysregulation of the basal ganglia motor circuit, and inhibition of movement. Various pathogenic pathways drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9f62167e1bb285906eaff95eadd49910
https://biblio.vub.ac.be/vubir/poster-glutamatergic-and-behavioral-abnormalities-after-intranigral-proteasome-inhibition-in-mice(95af44c6-9faf-48f9-a451-9e4c8c666ada).html
https://biblio.vub.ac.be/vubir/poster-glutamatergic-and-behavioral-abnormalities-after-intranigral-proteasome-inhibition-in-mice(95af44c6-9faf-48f9-a451-9e4c8c666ada).html