Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Bente Frølund"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Pyroptosis is a cell death process that causes inflammation and contributes to numerous diseases. Pyroptosis is mediated by caspase-1 family proteases that cleave the pore-forming protein gasdermin D, causing plasma membrane rupture and rele
Externí odkaz:
https://doaj.org/article/0daf9f697c8d412588cd9d243688b7ad
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f55264ea4ec34321bd1c19df12d9b0cb
Autor:
Stefanie Kickinger, Maria E. K. Lie, Akihiro Suemasa, Anas Al-Khawaja, Koichi Fujiwara, Mizuki Watanabe, Kristine S. Wilhelmsen, Christina B. Falk-Petersen, Bente Frølund, Satoshi Shuto, Gerhard F. Ecker, Petrine Wellendorph
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The betaine/GABA transporter 1 (BGT1) is a member of the GABA transporter (GAT) family with still elusive function, largely due to a lack of potent and selective tool compounds. Based on modeling, we here present the design, synthesis and pharmacolog
Externí odkaz:
https://doaj.org/article/eb62ced04b7242589c80acca580e939a
Autor:
Elina T. L’Estrade, Hanne D. Hansen, Christina Falk-Petersen, Anne Haugaard, Nane Griem-Krey, Sascha Jung, Hartmut Lüddens, Tanja Schirmeister, Maria Erlandsson, Tomas Ohlsson, Gitte M. Knudsen, Matthias M. Herth, Petrine Wellendorph, Bente Frølund
Publikováno v:
ACS Omega, Vol 4, Iss 5, Pp 8846-8851 (2019)
Externí odkaz:
https://doaj.org/article/bd6775d756734cf4926d9d3fcbed21d7
Autor:
Benjamin M Bader, Anne Steder, Anders Bue Klein, Bente Frølund, Olaf H U Schroeder, Anders A Jensen
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186147 (2017)
The numerous γ-aminobutyric acid type A receptor (GABAAR) subtypes are differentially expressed and mediate distinct functions at neuronal level. In this study we have investigated GABAAR-mediated modulation of the spontaneous activity patterns of p
Externí odkaz:
https://doaj.org/article/e5ba761261094646a1cff3cfda80c1dd
Autor:
Francesco Bavo, Steffanie Kickinger, Maria E.K. Lie, Christos avgerinos, Yue Xu, Kristine Sloth Wilhelmsen, Petrine Wellendorph, Bente Frølund
The GABA transporter 3 (GAT3) is a member of the GABA transporter (GAT) family proposed to have a role in regulating tonic inhibition. The GAT3-preferring substrate (S)-isoserine has shown beneficial effects in a mouse model of stroke accompanied by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92c9df537bdee4b47eb0337b74154a2b
https://doi.org/10.21203/rs.3.rs-2920118/v1
https://doi.org/10.21203/rs.3.rs-2920118/v1
Autor:
Martin Mortensen, Yue Xu, Mohamed A. Shehata, Jacob Krall, Margot Ernst, Bente Frølund, Trevor G. Smart
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31dc4883a202c73197f2e70d1daae39e
https://doi.org/10.1111/bph.16143
https://doi.org/10.1111/bph.16143
Autor:
Yongsong Tian, Mohamed A. Shehata, Stine Juul Gauger, Carolina Veronesi, Louise Hamborg, Louise Thiesen, Jesper Bruus-Jensen, Johanne Schlieper Royssen, Ulrike Leurs, Anne Sofie G. Larsen, Jacob Krall, Sara M.Ø. Solbak, Petrine Wellendorph, Bente Frølund
Publikováno v:
Journal of medicinal chemistry. 65(22)
Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7358ba6514148a943acf85104e042b88
https://pubmed.ncbi.nlm.nih.gov/36346645
https://pubmed.ncbi.nlm.nih.gov/36346645
Autor:
David E. Gloriam, Rebekka Löffler, Frederik Rostrup, Petrine Wellendorph, Bente Frølund, Christina Birkedahl Falk-Petersen, Kasper Harpsøe, Stine Buchleithner
Publikováno v:
Molecular Pharmacology. 100:46-56
Delta selective compound 2 (DS2; 4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide) is one of the most widely used tools to study selective actions mediated by δ-subunit-containing GABAA receptors. DS2 was discovered over 10 years ago, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b61e1339ce2ac4e170729ea407919188
https://doi.org/10.1124/molpharm.121.000266
https://doi.org/10.1124/molpharm.121.000266
Autor:
Yongsong Tian, Mohamed Shehata, Stine Gauger, Carolina Veronesi, Louise Hamborg, Louise Thiesen, Jesper Bruus-Jensen, Johanne Schlieper Royssen, Ulrike Leurs, Anne Sofie Larsen, Jacob Krall, Sara Solbak, Petrine Wellendorph, Bente Frølund
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a brain-relevant kinase and an emerging drug target for ischemic stroke and neurodegenerative disorders. Despite various reported CaMKIIα inhibitors, their usefulness is limited by low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b93ff7e52f322bbe50e39bfc68636bd5
https://doi.org/10.26434/chemrxiv-2022-54d5q
https://doi.org/10.26434/chemrxiv-2022-54d5q