Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Benoit de Crombrugghe"'
Publikováno v:
Journal of Osteoporosis, Vol 2023 (2023)
In previous study, we showed that nucleolar protein 66 (NO66) is a chromatin modifier and negatively regulates Osterix activity as well as mesenchymal progenitor differentiation. Genetic ablation of the NO66 (RIOX1) gene in cells of the Prx1-expressi
Externí odkaz:
https://doaj.org/article/37fd898b717f4d80b836f9001cba744b
Autor:
Xin Zhou, Allyson Beilter, Zhaohui Xu, Ruli Gao, Shunbin Xiong, Adriana Paulucci-Holthauzen, Guillermina Lozano, Benoit de Crombrugghe, Richard Gorlick
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Abstract The developmental origins of mesenchymal progenitor cells (MPCs) and molecular machineries regulating their fate and differentiation are far from defined owing to their complexity. Osteoblasts and adipocytes are descended from common MPCs. T
Externí odkaz:
https://doaj.org/article/eed50df3b8af4e8994f051ac95c9838e
Autor:
Süleyman Coşkun, Hsu Chao, Hema Vasavada, Kartoosh Heydari, Naomi Gonzales, Xin Zhou, Benoit de Crombrugghe, Karen K. Hirschi
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 581-590 (2014)
Hematopoietic stem cells (HSCs) reside within a specialized niche where interactions with vasculature, osteoblasts, and stromal components regulate their self-renewal and differentiation. Little is known about bone marrow niche formation or the role
Externí odkaz:
https://doaj.org/article/3c968bddcba44276b385be845dfbe5dc
Autor:
Chun-do Oh, Yue Lu, Shoudan Liang, Yuko Mori-Akiyama, Di Chen, Benoit de Crombrugghe, Hideyo Yasuda
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143156 (2015)
Externí odkaz:
https://doaj.org/article/3140c9153b49437babb33feab36219b0
Autor:
Xin Zhou, Klaus von der Mark, Stephen Henry, William Norton, Henry Adams, Benoit de Crombrugghe
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004820 (2014)
One of the crucial steps in endochondral bone formation is the replacement of a cartilage matrix produced by chondrocytes with bone trabeculae made by osteoblasts. However, the precise sources of osteoblasts responsible for trabecular bone formation
Externí odkaz:
https://doaj.org/article/65b058aec78d436bba860b8e0ebc3baa
Autor:
Chun-do Oh, Yue Lu, Shoudan Liang, Yuko Mori-Akiyama, Di Chen, Benoit de Crombrugghe, Hideyo Yasuda
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107577 (2014)
The transcription factor SOX9 plays an essential role in determining the fate of several cell types and is a master factor in regulation of chondrocyte development. Our aim was to determine which genes in the genome of chondrocytes are either directl
Externí odkaz:
https://doaj.org/article/9d8e85f3ff914d018856c7e299b0e495
Publikováno v:
BioTechniques, Vol 30, Iss 1, Pp 94-100 (2001)
The SOS recruitment system (SRS), a recently developed method for detecting protein-protein interactions, provides an attractive alternative to identify biologically important protein interactions. In SRS, the protein-protein interactions take place
Externí odkaz:
https://doaj.org/article/2fdb1868c10b417e9562e6121b51ae3a
Autor:
Wook-Young Baek, Seung-Yoon Park, Yeo Hyang Kim, Min-A Lee, Tae-Hwan Kwon, Kwon-Moo Park, Benoit de Crombrugghe, Jung-Eun Kim
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69859 (2013)
Osterix (Osx) is an essential transcription factor for osteoblast differentiation and bone formation. Osx knockout show a complete absence of bone formation, whereas Osx conditional knockout in osteoblasts produce an osteopenic phenotype after birth.
Externí odkaz:
https://doaj.org/article/febc64015e6d4ad9972df10dd9638a26
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58104 (2013)
Osterix (Osx) is an osteoblast-specific transcription factor which is essential for bone formation. MicroRNAs (miRNAs) have been previously shown to be involved in osteogenesis. However, it is unclear whether Osx is involved in the regulation of miRN
Externí odkaz:
https://doaj.org/article/5db884a4451347d7aeb98c6362948d0a
Autor:
Chun-do Oh, Sankar N Maity, Jing-Fang Lu, Jiexin Zhang, Shoudan Liang, Francoise Coustry, Benoit de Crombrugghe, Hideyo Yasuda
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10113 (2010)
Our previous work has provided strong evidence that the transcription factor SOX9 is completely needed for chondrogenic differentiation and cartilage formation acting as a "master switch" in this differentiation. Heterozygous mutations in SOX9 cause
Externí odkaz:
https://doaj.org/article/8647803e00724066a9b5a3390dc0d130