Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Benoit Tyl"'
Autor:
Elaina Bolinger, Benoit Tyl
Publikováno v:
Journal of Medical Internet Research, Vol 26, p e54518 (2024)
Evidence of clinical impact is critical to unlock the potential of digital health solutions (DHSs), yet many solutions are failing to deliver positive clinical results. We argue in this viewpoint that this failure is linked to current approaches to D
Externí odkaz:
https://doaj.org/article/29318d86bbdc4e7ab133361fe3a76d17
Autor:
R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans‐Peter Brunner‐La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G.F. Cleland, James P. Cook, Simon deDenus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van derHarst, Åsa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay‐Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried März, John J.V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton‐Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N.A. Palmer, Guillaume Paré, Markus Perola, Louis‐Philippe Lemieux Perreault, Eliana Portilla‐Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P.R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica vanSetten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garðar Sveinbjörnsson, Mari‐Liis Tammesoo, Jean‐Claude Tardif, Kent D. Taylor, Maris Teder‐Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp‐Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges‐Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Regeneron Genetics Center, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie‐Pierre Dubé, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith
Publikováno v:
ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)
Abstract Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries,
Externí odkaz:
https://doaj.org/article/77600c13420346d3a1c4c66140b2a3c7
Autor:
Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K. Hedman, Jemma B. Wilk, Michael P. Morley, Mark D. Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G. Aragam, Johan Ärnlöv, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Jeffrey Brandimarto, Michael R. Brown, Leonard Buckbinder, David J. Carey, Daniel I. Chasman, Xing Chen, Xu Chen, Jonathan Chung, William Chutkow, James P. Cook, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Michael E. Dunn, Gunnar Engström, Tõnu Esko, Stephan B. Felix, Chris Finan, Ian Ford, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Rebecca Gutmann, Christopher M. Haggerty, Pim van der Harst, Craig L. Hyde, Erik Ingelsson, J. Wouter Jukema, Maryam Kavousi, Kay-Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian’an Luan, Patrik Magnusson, Anubha Mahajan, Kenneth B. Margulies, Winfried März, Olle Melander, Ify R. Mordi, Thomas Morgan, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Alexander Niessner, Teemu Niiranen, Michelle L. O’Donoghue, Anjali T. Owens, Colin N. A. Palmer, Helen M. Parry, Markus Perola, Eliana Portilla-Fernandez, Bruce M. Psaty, Regeneron Genetics Center, Kenneth M. Rice, Paul M. Ridker, Simon P. R. Romaine, Jerome I. Rotter, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Steen Stender, David J. Stott, Per Svensson, Mari-Liis Tammesoo, Kent D. Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Benoit Tyl, Andre G. Uitterlinden, Abirami Veluchamy, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Dawn Waterworth, Peter E. Weeke, Raul Weiss, Kerri L. Wiggins, Heming Xing, Laura M. Yerges-Armstrong, Bing Yu, Faiez Zannad, Jing Hua Zhao, Harry Hemingway, Nilesh J. Samani, John J. V. McMurray, Jian Yang, Peter M. Visscher, Christopher Newton-Cheh, Anders Malarstig, Hilma Holm, Steven A. Lubitz, Naveed Sattar, Michael V. Holmes, Thomas P. Cappola, Folkert W. Asselbergs, Aroon D. Hingorani, Karoline Kuchenbaecker, Patrick T. Ellinor, Chim C. Lang, Kari Stefansson, J. Gustav Smith, Ramachandran S. Vasan, Daniel I. Swerdlow, R. Thomas Lumbers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 1
Externí odkaz:
https://doaj.org/article/b5721b6147184dcfac6753b6e07e56dd
Autor:
Marc-André Legault, Johanna Sandoval, Sylvie Provost, Amina Barhdadi, Louis-Philippe Lemieux Perreault, Sonia Shah, R Thomas Lumbers, Simon de Denus, Benoit Tyl, Jean-Claude Tardif, Marie-Pierre Dubé
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236193 (2020)
BackgroundNaturally occurring human genetic variants provide a valuable tool to identify drug targets and guide drug prioritization and clinical trial design. Ivabradine is a heart rate lowering drug with protective effects on heart failure despite i
Externí odkaz:
https://doaj.org/article/52a9a7b767ca4bfc96f14048d78d9942
Autor:
Liyong Zhang, David Smyth, Mohammad Al-Khalaf, Alice Blet, Qiujiang Du, Jordan Bernick, Michael Gong, Xu Chi, Yena Oh, Malaika Roba-Oshin, Elizabeth Coletta, Michel Feletou, Anthony O. Gramolini, Kyoung-Han Kim, Thais Coutinho, James L. Januzzi, Benoit Tyl, Andre Ziegler, Peter P. Liu
Publikováno v:
Nature Cardiovascular Research. 1:1195-1214
Heart failure (HF) is a rising global cardiovascular epidemic driven by aging and chronic inflammation. As elderly populations continue to increase, precision treatments for age-related cardiac decline are urgently needed. Here we report that cardiac
Autor:
Megan Schroeder, Yvonne Mei Fong Lim, Gianluigi Savarese, Kiliana Suzart‐Woischnik, Claire Baudier, Tomasz Dyszynski, Ilonca Vaartjes, Marinus J.C. Eijkemans, Alicia Uijl, Ronald Herrera, Eleni Vradi, Jasper J. Brugts, Hans‐Peter Brunner‐La Rocca, Vanessa Blanc‐Guillemaud, Sandra Waechter, Fabrice Couvelard, Benoit Tyl, Samuel Fatoba, Arno W. Hoes, Lars H. Lund, Christoph Gerlinger, Folkert W. Asselbergs, Diederick E. Grobbee, Maureen Cronin, Stefan Koudstaal
Publikováno v:
Schroeder, M, Lim, Y M F, Savarese, G, Suzart-Woischnik, K, Baudier, C, Dyszynski, T, Vaartjes, I, Eijkemans, M J C, Uijl, A, Herrera, R, Vradi, E, Brugts, J J, Brunner-la Rocca, H-P, Blanc-Guillemaud, V, Waechter, S, Couvelard, F, Tyl, B, Fatoba, S, Hoes, A W, Lund, L H, Gerlinger, C, Asselbergs, F W, Grobbee, D E, Cronin, M & Koudstaal, S 2023, ' Sex differences in the generalizability of randomized clinical trials in heart failure with reduced ejection fraction ', European Journal of Heart Failure, vol. 25, no. 6 . https://doi.org/10.1002/ejhf.2868
Aims: In order to understand how sex differences impact the generalizability of randomized clinical trials (RCTs) in patients with heart failure (HF) and reduced ejection fraction (HFrEF), we sought to compare clinical characteristics and clinical ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e196e20202299c900507f06b0d792a13
https://research.vumc.nl/en/publications/721d1adf-2536-4815-9891-2b51d5f7ef30
https://research.vumc.nl/en/publications/721d1adf-2536-4815-9891-2b51d5f7ef30
Autor:
Susanne Roesch, Emilie Royere, Willy Gosgnach, Ariane Bonnin, Benoit Tyl, Elodie Bossard, Patricia Sansilvestri-Morel, Pascal Berson, Muriel Bouly, Michel Komajda, Laura Xuereb, Nicolas Diguet, Pascal Rigouin, Peter Bernhardt, Marie-Pierre Bourguignon
Publikováno v:
Translational Research. 238:36-48
Little is known about the mechanisms of aging on vascular beds and its relationship with tetra and di-hydrobiopterin (BH4 and BH2) levels. This observational clinical study analyzed the impact of aging on plasma and platelet biopterins, cutaneous blo
Autor:
Maureen Cronin, Claire Baudier, Megan Molnar, Marinus J.C. Eijkemans, Folkert W. Asselbergs, Jasper J. Brugts, Yvonne Mei Fong Lim, Ilonca Vaartjes, Arno W. Hoes, Alicia Uijl, Vanessa Blanc-Guillemaud, Gianluigi Savarese, Christoph Gerlinger, Diederick E. Grobbee, Stefan Koudstaal, Hans-Peter Brunner-La Rocca, Tomasz Dyszynski, Lars Lund, Fabrice Couvelard, Eleni Vradi, Benoit Tyl, Kiliana Suzart-Woischnik, Sandra Waechter
Publikováno v:
European Heart Journal-Quality of Care and Clinical Outcomes, 8(7), 761-769. Oxford University Press
European Heart Journal
Lim, Y M F, Molnar, M, Vaartjes, I, Savarese, G, Eijkemans, M J C, Uijl, A, Vradi, E, Suzart-Woischnik, K, Brugts, J J, Brunner-la Rocca, H-P, Blanc-Guillemaud, V, Couvelard, F, Baudier, C, Dyszynski, T, Waechter, S, Lund, L H, Hoes, A W, Tyl, B, Asselbergs, F W, Gerlinger, C, Grobbee, D E, Cronin, M & Koudstaal, S 2022, ' Generalizability of randomized controlled trials in heart failure with reduced ejection fraction ', European Heart Journal-Quality of Care and Clinical Outcomes, vol. 8, no. 7, pp. 761-769 . https://doi.org/10.1093/ehjqcco/qcab070
European heart journal. Quality of care & clinical outcomes, 8(7). Oxford University Press
European heart journal. Quality of care & clinical outcomes, 8(7), 761-769. Oxford University Press
European Heart Journal
Lim, Y M F, Molnar, M, Vaartjes, I, Savarese, G, Eijkemans, M J C, Uijl, A, Vradi, E, Suzart-Woischnik, K, Brugts, J J, Brunner-la Rocca, H-P, Blanc-Guillemaud, V, Couvelard, F, Baudier, C, Dyszynski, T, Waechter, S, Lund, L H, Hoes, A W, Tyl, B, Asselbergs, F W, Gerlinger, C, Grobbee, D E, Cronin, M & Koudstaal, S 2022, ' Generalizability of randomized controlled trials in heart failure with reduced ejection fraction ', European Heart Journal-Quality of Care and Clinical Outcomes, vol. 8, no. 7, pp. 761-769 . https://doi.org/10.1093/ehjqcco/qcab070
European heart journal. Quality of care & clinical outcomes, 8(7). Oxford University Press
European heart journal. Quality of care & clinical outcomes, 8(7), 761-769. Oxford University Press
Background Heart failure (HF) trials have stringent inclusion and exclusion criteria, but limited data exist regarding generalizability of trials. We compared patient characteristics and outcomes between patients with HF and reduced ejection fraction
Publikováno v:
Journal of cardiovascular imaging. 30(3)
This study aims to investigate normal changes throughout aging of the heart in cardiac magnetic resonance (CMR) imaging in healthy volunteers. While type 2 diabetes mellitus is a frequent finding in the elderly population, also the influence of this
Autor:
Amitava Banerjee, Suliang Chen, Muhammad Dashtban, Laura Pasea, Johan H Thygesen, Ghazaleh Fatemifar, Benoit Tyl, Tomasz Dyszynski, Folkert W. Asselbergs, Lars H. Lund, Tom Lumbers, Spiros Denaxas, Harry Hemingway
Publikováno v:
SSRN Electronic Journal.
BackgroundReliable identification of heart failure (HF) subtypes might allow targeted management. Machine learning (ML) has been used to explore HF subtypes, but neither across large, independent, population-based datasets, nor across the full spectr