Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial

Autor: Fabien Zoulim, Claire Fournier, François Habersetzer, Martin Sprinzl, Stanislas Pol, Carla S Coffin, Vincent Leroy, Mang Ma, Heiner Wedemeyer, Ansgar W Lohse, Robert Thimme, Karine Lugardon, Perrine Martin, Bérangère Bastien, Benoit Sansas, Nathalie Adda, Celine Halluard, Kaïdre Bendjama, Maud Brandely, Geneviève Inchauspé

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 16, Iss 2, Pp 388-399 (2020)

Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs. Cohort and pre-clinical studies have established the link between a functional T-cell-mounted immunity and resolution of infection. TG1050 is an adenovirus 5

Externí odkaz: https://doaj.org/article/c456bcbade694a3c9f70d46d5542f9b0

A meta-analysis of the antiviral activity of the HBV-specific immunotherapeutic TG1050 confirms its value over a wide range of HBsAg levels in a persistent HBV pre-clinical model

Autor: Nathalie Silvestre, Perrine Martin, A. Evlachev, Geneviève Inchauspé, Karine Lélu, Roland Kratzer, Doris Schmitt, Benoit Sansas

Publikováno v: Human Vaccines & Immunotherapeutics

Pre-clinical models mimicking persistent hepatitis B virus (HBV) expression are seldom, do not capture all features of a human chronic infection and due to their complexity, are subject to variability. We report a meta-analysis of seven experiments p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd74b4a1461fd543511de2ba9d47fca
http://europepmc.org/articles/PMC6037470

A multi-antigenic MVA vaccine increases efficacy of combination chemotherapy against Mycobacterium tuberculosis

Autor: Benoit Sansas, Cristina Vilaplana, Geneviève Inchauspé, Nathalie Silvestre, Aurélie Ray, Charles Antoine Coupet, Jean-Baptiste Marchand, Patricia Kleinpeter, H. Schultz, Chantal Hoffmann, Eric L. Nuermberger, Doris Schmitt, Khisimuzi Mdluli, Pere-Joan Cardona, Heena Soni, Sandeep Tyagi, Stéphane Leung-Theung-Long, Marie Gouanvic, Paul J. Converse, Lilibeth Arias

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0196815 (2018)
PLoS ONE
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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PLOS ONE

Despite the existence of the prophylactic Bacille Calmette-Guérin (BCG) vaccine, infection by Mycobacterium tuberculosis (Mtb) remains a major public health issue causing up to 1.8 million annual deaths worldwide. Increasing prevalence of Mtb strain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d151de48ebbdf8fec504da85b72c5979
http://europepmc.org/articles/PMC5931632?pdf=render

Typing of killer-cell immunoglobulin-like receptors and their cognate human leukocyte antigen class I ligands predicts survival of Chinese Han patients with metastatic non-small-cell lung cancer

Autor: J. Chang, Xianghua Wu, Fang Liu, Xavier Préville, Hui Yu, Bin Kang, Xia Meng, Romain Micol, Benoit Sansas, Jialei Wang

Non-small-cell lung cancer (NSCLC) may establish an immunosuppressive tumor microenvironment that is conducive to tumor growth. Natural killer (NK) cells play a pivotal role in immunological surveillance. Activation of NK cells partially depends on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd3683c936f85f6fb700ff0e858c0e2
https://europepmc.org/articles/PMC5351717/

A meta-analysis of the antiviral activity of the HBV-specific immunotherapeutic TG1050 confirms its value over a wide range of HBsAg levels in a persistent HBV pre-clinical model

Autor: Roland Kratzer, Benoît Sansas, Karine Lélu, Alexei Evlachev, Doris Schmitt, Nathalie Silvestre, Geneviève Inchauspé, Perrine Martin

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 14, Iss 6, Pp 1417-1422 (2018)

Pre-clinical models mimicking persistent hepatitis B virus (HBV) expression are seldom, do not capture all features of a human chronic infection and due to their complexity, are subject to variability. We report a meta-analysis of seven experiments p

Externí odkaz: https://doaj.org/article/e396c2e09f3f455183af950de311beb9