Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Benoit Mouzon"'
Autor:
Robyn McCartan, Arissa Gratkowski, Mackenzie Browning, Coral Hahn-Townsend, Scott Ferguson, Alexander Morin, Corbin Bachmeier, Andrew Pearson, Larry Brown, Michael Mullan, Fiona Crawford, Radouil Tzekov, Benoit Mouzon
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 303-318 (2023)
Traumatic optic neuropathy (TON) is a condition in which acute injury to the optic nerve from direct or indirect trauma results in vision loss. The most common cause of TON is indirect injury to the optic nerve caused by concussive forces that are tr
Externí odkaz:
https://doaj.org/article/15a7789f959a45d3ba98ea59df966697
Autor:
Scott Ferguson, Robyn McCartan, Mackenzie Browning, Coral Hahn-Townsend, Arissa Gratkowski, Alexander Morin, Laila Abdullah, Ghania Ait-Ghezala, Joseph Ojo, Kimberly Sullivan, Michael Mullan, Fiona Crawford, Benoit Mouzon
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Chemical and pharmaceutical exposures have been associated with the development of Gulf War Illness (GWI), but how these factors interact with the pathophysiology of traumatic brain injury (TBI) remains an area of study that has received lit
Externí odkaz:
https://doaj.org/article/f7e54544c7da46d0b526cdf3bd7de54b
Autor:
Alexander Morin, Roderick Davis, Teresa Darcey, Michael Mullan, Benoit Mouzon, Fiona Crawford
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-12 (2022)
Abstract Repetitive mild traumatic brain injury (r-mTBI) is the most widespread type of brain trauma worldwide. The cumulative injury effect triggers long-lasting pathological and molecular changes that may increase risk of chronic neurodegenerative
Externí odkaz:
https://doaj.org/article/c8bce0451c4145d3b6cabfaef75c0a43
Autor:
Maxwell Eisenbaum, Andrew Pearson, Arissa Gratkowski, Benoit Mouzon, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeier
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Repetitive head trauma has been associated with the accumulation of tau species in the brain. Our prior work showed brain vascular mural cells contribute to tau processing in the brain, and that these cells progressively degenerate following
Externí odkaz:
https://doaj.org/article/62123cb0b1524b6c8ffeac43d3eb0097
Autor:
Alexander Morin, Benoit Mouzon, Scott Ferguson, Daniel Paris, Nicole Saltiel, Mackenzie Browning, Mike Mullan, Fiona Crawford
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract To date, an overwhelming number of preclinical studies have addressed acute treatment in mild TBI (mTBI) and repetitive mTBI (r-mTBI), whereas, in humans, there often exists a significant time gap between the injury and the first medical int
Externí odkaz:
https://doaj.org/article/bbf6c84a7c6c42d488e694f06ccd3ad2
Autor:
Alexander Morin, Benoit Mouzon, Scott Ferguson, Daniel Paris, Mackenzie Browning, William Stewart, Mike Mullan, Fiona Crawford
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Repeated exposure to mild TBI (mTBI) has been linked to an increased risk of Alzheimer’s disease (AD), chronic traumatic encephalopathy (CTE) and other neurodegenerative diseases. Some pathological features typically observed in AD have be
Externí odkaz:
https://doaj.org/article/74917cd4cc8d4bd08eb07def1b7cacf9
Autor:
Joseph Ojo, Max Eisenbaum, Ben Shackleton, Cillian Lynch, Utsav Joshi, Nicole Saltiel, Andrew Pearson, Charis Ringland, Daniel Paris, Benoit Mouzon, Michael Mullan, Fiona Crawford, Corbin Bachmeier
Publikováno v:
Neurobiology of Disease, Vol 150, Iss , Pp 105237- (2021)
A pathological characteristic of repetitive traumatic brain injury (TBI) is the deposition of hyperphosphorylated and aggregated tau species in the brain and increased levels of extracellular monomeric tau are believed to play a role in the pathogene
Externí odkaz:
https://doaj.org/article/3637edde966242adb0ffcb73e4b2ca7e
Autor:
Joseph O. Ojo, Gogce Crynen, Moustafa Algamal, Prashanti Vallabhaneni, Paige Leary, Benoit Mouzon, Jon M. Reed, Michael Mullan, Fiona Crawford
Publikováno v:
ASN Neuro, Vol 12 (2020)
No concerted investigation has been conducted to explore overlapping and distinct pathobiological mechanisms between repetitive mild traumatic brain injury (r-mTBI) and tau/amyloid proteinopathies considering the long history of association between T
Externí odkaz:
https://doaj.org/article/2546992337674853bc38fdef598eec08
Autor:
Jonas Elias Schweig, Hailan Yao, David Beaulieu-Abdelahad, Ghania Ait-Ghezala, Benoit Mouzon, Fiona Crawford, Michael Mullan, Daniel Paris
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-25 (2017)
Abstract The pathology of Alzheimer’s disease (AD) is characterized by dystrophic neurites (DNs) surrounding extracellular Aβ-plaques, microgliosis, astrogliosis, intraneuronal tau hyperphosphorylation and aggregation. We have previously shown tha
Externí odkaz:
https://doaj.org/article/3df914653fbb490c9478c2c0d2e6afe0
Autor:
Joseph O. Ojo, Moustafa Algamal, Paige Leary, Laila Abdullah, Benoit Mouzon, James E. Evans, Michael Mullan, Fiona Crawford
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Repetitive mild traumatic brain injury (rmTBI) is a major epigenetic risk factor for Alzheimer’s disease (AD). The precise nature of how rmTBI leads to or precipitates AD pathology is currently unknown. Numerous neurological conditions have shown a
Externí odkaz:
https://doaj.org/article/c9130f6e7c6746f193078e5bf006be92