The Drosophila Fab-7 boundary modulates Abd-B gene activity by guiding an inversion of collinear chromatin organization and alternate promoter use

Autor: Laura Moniot-Perron, Benoit Moindrot, Line Manceau, Joanne Edouard, Yan Jaszczyszyn, Pascale Gilardi-Hebenstreit, Céline Hernandez, Sébastien Bloyer, Daan Noordermeer

Publikováno v: Cell Reports, Vol 42, Iss 1, Pp 111967- (2023)

Summary: Hox genes encode transcription factors that specify segmental identities along the anteroposterior body axis. These genes are organized in clusters, where their order corresponds to their activity along the body axis, a feature known as coll

Externí odkaz: https://doaj.org/article/cf271bec9cdb40d08006da377b3f33ef

Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation

Autor: Tatyana B. Nesterova, Guifeng Wei, Heather Coker, Greta Pintacuda, Joseph S. Bowness, Tianyi Zhang, Mafalda Almeida, Bianca Bloechl, Benoit Moindrot, Emma J. Carter, Ines Alvarez Rodrigo, Qi Pan, Ying Bi, Chun-Xiao Song, Neil Brockdorff

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Xist RNA is the master regulator of X chromosome inactivation. Here the authors describe a systematic analysis of Xist-mediated allelic silencing in mouse ESC models and define the contribution of different pathways that regulate gene silencing.

Externí odkaz: https://doaj.org/article/1099fcaec9864035a2a87b2701f1ba55

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

Autor: Benoit Moindrot, Andrea Cerase, Heather Coker, Osamu Masui, Anne Grijzenhout, Greta Pintacuda, Lothar Schermelleh, Tatyana B. Nesterova, Neil Brockdorff

Publikováno v: Cell Reports, Vol 12, Iss 4, Pp 562-572 (2015)

X-chromosome inactivation is the process that evolved in mammals to equalize levels of X-linked gene expression in XX females relative to XY males. Silencing of a single X chromosome in female cells is mediated by the non-coding RNA Xist. Although pr

Externí odkaz: https://doaj.org/article/1128f7ecf32f4264b63b383ff7c04811

Detection of Allele-Specific 3D Chromatin Interactions Using High-Resolution In-Nucleus 4C-seq

Autor: Mélanie, Miranda, Daan, Noordermeer, Benoit, Moindrot

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2532

Chromosome conformation capture techniques are a set of methods used to determine 3D genome organization through the capture and identification of physical contacts between pairs of genomic loci. Among them, 4C-seq (circular chromosome conformation c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::032a0bf9603f3c3e0cc2f620f5cf59ea
https://pubmed.ncbi.nlm.nih.gov/35867243

Detection of Allele-Specific 3D Chromatin Interactions Using High-Resolution In-Nucleus 4C-seq

Autor: Mélanie Miranda, Daan Noordermeer, Benoit Moindrot

Publikováno v: Spatial Genome Organization ISBN: 9781071624968
Spatial Genome Organization
Spatial Genome Organization, 2532, Springer US, pp.15-33, 2022, Methods in Molecular Biology, ⟨10.1007/978-1-0716-2497-5_2⟩

International audience; Chromosome Conformation Capture techniques are a set of methods used to determine 3D genome organization through the capture and identification of physical contacts between pairs of genomic loci. Among them, 4C-seq (Circular C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f257757a15dfd8bee38b27172c58cdec
https://doi.org/10.1007/978-1-0716-2497-5_2