Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Benoit Massonnet"'
Autor:
Yumi Yamamoto, Patricia Sanwald Ducray, Marcus Björnsson, Kevin Smart, Paul Grimsey, Suresh Vatakuti, Agnes Portron, Benoit Massonnet, Daniel A. Norris, Hanna E. Silber Baumann
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 9, Pp 1213-1226 (2023)
Abstract Tominersen is an intrathecally administered antisense oligonucleotide targeting huntingtin mRNA which leads to a dose‐dependent, reversible lowering of cerebrospinal fluid (CSF) mutant huntingtin protein concentration in individuals with H
Externí odkaz:
https://doaj.org/article/3bbd4d99f8d546848ac3c29756f46b8f
Autor:
Stephanie Vauleon, Katharina Schutz, Benoit Massonnet, Nanda Gruben, Marianne Manchester, Alessandra Buehler, Eginhard Schick, Lauren Boak, David J. Hawellek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Huntington’s disease (HD) is caused by a cytosine adenine guanine-repeat expansion in the huntingtin gene. This results in the production of toxic mutant huntingtin protein (mHTT), which has an elongated polyglutamine (polyQ) stretch near
Externí odkaz:
https://doaj.org/article/bad2f4a1d56e443989a5c40b6c57ac69
Autor:
Scott Schobel, Lauren Boak, Nanda Gruben, Katharina Schutz, Stephanie Vauleon, Marianne Manchester, David J. Hawellek, Benoit Massonnet
Publikováno v:
D: Wet biomarkers.
Background Huntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin gene, resulting in the production of toxic mutant huntingtin protein (mHTT). Quantification of mHTT in the cerebrospinal fluid (CSF) of patients with HD usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2024172727a436f3d55be361de7a64
https://doi.org/10.1136/jnnp-2021-ehdn.32
https://doi.org/10.1136/jnnp-2021-ehdn.32