Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Benoit J. Van den Eynde"'
Autor:
Tereza Dvorakova, Veronica Finisguerra, Matteo Formenti, Axelle Loriot, Loubna Boudhan, Jingjing Zhu, Benoit J. Van den Eynde
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract While adoptive cell therapy has shown success in hematological malignancies, its potential against solid tumors is hindered by an immunosuppressive tumor microenvironment (TME). In recent years, members of the hypoxia-inducible factor (HIF)
Externí odkaz:
https://doaj.org/article/5dce5884434645d5b5af3f7454364fe5
Autor:
Ramiro A. Ramirez-Valdez, Faezzah Baharom, Ahad Khalilnezhad, Sloane C. Fussell, Dalton J. Hermans, Alexander M. Schrager, Kennedy K.S. Tobin, Geoffrey M. Lynn, Shabnam Khalilnezhad, Florent Ginhoux, Benoit J. Van den Eynde, Carol Sze Ki Leung, Andrew S. Ishizuka, Robert A. Seder
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112599- (2023)
Summary: Therapeutic neoantigen cancer vaccines have limited clinical efficacy to date. Here, we identify a heterologous prime-boost vaccination strategy using a self-assembling peptide nanoparticle TLR-7/8 agonist (SNP) vaccine prime and a chimp ade
Externí odkaz:
https://doaj.org/article/454b3df22d3e403a94c2b7585b80011e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Tryptophan is an essential amino acid, which is not only a building block for protein synthesis, but also a precursor for the biosynthesis of co-enzymes and neuromodulators, such as NAD/NADP(H), kynurenic acid, melatonin and serotonin. It also plays
Externí odkaz:
https://doaj.org/article/becb4e76f8b64d06a2dc8cae8aaca4f8
Autor:
Delia Hoffmann, Tereza Dvorakova, Florence Schramme, Vincent Stroobant, Benoit J. Van den Eynde
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) catalyze the rate-limiting step of tryptophan catabolism along the kynurenine pathway, which has important immuno suppressive properties, particularly in tumor cells and dendri
Externí odkaz:
https://doaj.org/article/9e994214e54e48f28fa3c66a4c7b348f
Publikováno v:
Cells, Vol 11, Iss 3, p 421 (2022)
Four proteasome subtypes are commonly present in mammalian tissues: standard proteasomes, which contain the standard catalytic subunits β1, β2 and β5; immunoproteasomes containing the immuno-subunits β1i, β2i and β5i; and two intermediate prote
Externí odkaz:
https://doaj.org/article/dd0df3005f334de0be42fc5c55afa055
Autor:
Jingjing Zhu, Céline G. Powis de Tenbossche, Stefania Cané, Didier Colau, Nicolas van Baren, Christophe Lurquin, Anne-Marie Schmitt-Verhulst, Peter Liljeström, Catherine Uyttenhove, Benoit J. Van den Eynde
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cancer immunotherapy is ineffective in a subset of patients. Here the authors show that, in a mouse model of melanoma, resistance to immune checkpoint inhibitors relies on loss of tumor-specific T cells through FasL-mediated apoptosis triggered by po
Externí odkaz:
https://doaj.org/article/03b05d3e6ab641c1b1de96121c6dfbee
Autor:
Otavia L. Caballero, Qi Zhao, Donata Rimoldi, Brian J. Stevenson, Suzanne Svobodová, Sylvie Devalle, Ute F. Röhrig, Anna Pagotto, Olivier Michielin, Daniel Speiser, Jedd D. Wolchok, Cailian Liu, Tanja Pejovic, Kunle Odunsi, Francis Brasseur, Benoit J. Van den Eynde, Lloyd J. Old, Xin Lu, Jonathan Cebon, Robert L. Strausberg, Andrew J. Simpson
Publikováno v:
PLoS ONE, Vol 5, Iss 11 (2010)
Externí odkaz:
https://doaj.org/article/0f9beb27778e421b8151de1aca4d0eb8
Autor:
Miranda C. Lahman, Thomas M. Schmitt, Kelly G. Paulson, Nathalie Vigneron, Denise Buenrostro, Felecia D. Wagener, Valentin Voillet, Lauren Martin, Raphael Gottardo, Jason Bielas, Julie M. McElrath, Derek L. Stirewalt, Era L. Pogosova-Agadjanyan, Cecilia C. Yeung, Robert H. Pierce, Daniel N. Egan, Merav Bar, Paul C. Hendrie, Sinéad Kinsella, Aesha Vakil, Jonah Butler, Mary Chaffee, Jonathan Linton, Megan S. McAfee, Daniel S. Hunter, Marie Bleakley, Anthony Rongvaux, Benoit J. Van den Eynde, Aude G. Chapuis, Philip D. Greenberg
Publikováno v:
Sci Transl Med
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Designing effective antileukemic immunotherapy will require understanding mechanisms underlying tumor control or resistance. Here, we report a mechanism of escape from immunologic targeting in an acute myeloid leukemia (AML) patient, who relapsed 1 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ab8910054866ad4b7f3c2247308f44
https://doi.org/10.1126/scitranslmed.abg8070
https://doi.org/10.1126/scitranslmed.abg8070
Autor:
Benoit J. Van den Eynde, Etienne Marbaix, Julie Lelotte, Nicolas van Baren, Jean-Christophe Renauld, Marie-Claire Letellier, Simon Klaessens, Marie Solvay, Aurélie Daumerie, Caroline Bouzin, Vincent Stroobant, Tereza Dvorakova, Delia Hoffmann
Supplementary figures and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e5b11eee0feb91d4c6a59bc085457d
https://doi.org/10.1158/2326-6066.22543315.v1
https://doi.org/10.1158/2326-6066.22543315.v1
Autor:
Benoit J. Van den Eynde, Gregory Driessens, Julie Preillon, Vincent Stroobant, Luc Pilotte, Delia Hoffmann, Kim Frederix, Stefano Crosignani, Florence Schramme
Supplementary tables and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a519215ebea4592f0eae90ce9cd84eb
https://doi.org/10.1158/2326-6066.22543473
https://doi.org/10.1158/2326-6066.22543473