Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Benoit H. Dessailly"'
Autor:
Sergio Picart-Armada, Steven J Barrett, David R Willé, Alexandre Perera-Lluna, Alex Gutteridge, Benoit H Dessailly
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007276 (2019)
In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information. He
Externí odkaz:
https://doaj.org/article/01d606f62d954bd9960910aea0304e90
Autor:
Yi-An Chen, Lokesh P Tripathi, Benoit H Dessailly, Johan Nyström-Persson, Shandar Ahmad, Kenji Mizuguchi
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99030 (2014)
Prioritising candidate genes for further experimental characterisation is an essential, yet challenging task in biomedical research. One way of achieving this goal is to identify specific biological themes that are enriched within the gene set of int
Externí odkaz:
https://doaj.org/article/012ece2142ca4a7aa4dd881c14992167
Autor:
Choon Kit Tang, Taiki Aoshi, Nao Jounai, Junichi Ito, Keiichi Ohata, Kouji Kobiyama, Benoit H Dessailly, Etsushi Kuroda, Shizuo Akira, Kenji Mizuguchi, Cevayir Coban, Ken J Ishii
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60038 (2013)
5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials. Despite its multiple biological
Externí odkaz:
https://doaj.org/article/ea094f7d4bfb48cf9ac352f2617c01e1
Autor:
Alexandre Perera-Lluna, Steven J. Barrett, Alex Gutteridge, David R. Willé, Benoit H. Dessailly, Sergio Picart-Armada
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 9, p e1007276 (2019)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS Computational Biology, Vol 15, Iss 9, p e1007276 (2019)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname
In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676bbb5584ea6460f1c010a0871873bf
http://europepmc.org/articles/PMC6743778
http://europepmc.org/articles/PMC6743778
Publikováno v:
From Protein Structure to Function with Bioinformatics ISBN: 9789402410679
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3edeee19398662c5cd182f72753b4e9
https://doi.org/10.1007/978-94-024-1069-3_9
https://doi.org/10.1007/978-94-024-1069-3_9
Autor:
Corin Yeats, Christine A. Orengo, Benoit H. Dessailly, Finn Werner, Björn Brindefalk, Anthony M. Poole
Publikováno v:
Nucleic Acids Research
The TATA binding protein (TBP) is an essential transcription initiation factor in Archaea and Eucarya. Bacteria lack TBP, and instead use sigma factors for transcription initiation. TBP has a symmetric structure comprising two repeated TBP domains. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4faa91837932a42657207e47ee0c53aa
https://doi.org/10.1093/nar/gkt045
https://doi.org/10.1093/nar/gkt045
Autor:
Andreas F.-P. Sonnen, John E. Ladbury, Edward J. Evans, Christine A. Orengo, Chao Yu, Simon J. Davis, Benoit H. Dessailly, Loren J. Stagg, David I. Stuart, Robert J.C. Gilbert, Roger George, Shinji Ikemizu
Publikováno v:
The Journal of Biological Chemistry
The inhibitory T-cell surface-expressed receptor, cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), which belongs to the class of cell surface proteins phosphorylated by extrinsic tyrosine kinases that also includes antigen receptors, binds the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d5272e67870eac5d58c09d9cd81706
http://europepmc.org/articles/PMC3057841
http://europepmc.org/articles/PMC3057841
Publikováno v:
Structure. 18:1522-1535
Some superfamilies contain large numbers of protein domains with very different functions. The ability to refine the functional classification of domains within these superfamilies is necessary for better understanding the evolution of functions and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9eab1916912effa1ea6f3cfe3064f4c
https://doi.org/10.1016/j.str.2010.08.017
https://doi.org/10.1016/j.str.2010.08.017
Publikováno v:
Structure. 18:1233-1243
Transient interactions, which involve protein interactions that are formed and broken easily, are important in many aspects of cellular function. Here we describe structural and functional properties of transient interactions between globular domains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bae1e0f4ad4cc9d15d10544a6775f30
https://doi.org/10.1016/j.str.2010.08.007
https://doi.org/10.1016/j.str.2010.08.007
Autor:
Lukasz Jaroszewski, David A. Lee, Kouranov Andrei Y, Rajesh Nair, Adam Godzik, Christine A. Orengo, Benoit H. Dessailly, J. Eduardo Fajardo, Andras Fiser, Burkhard Rost
Publikováno v:
Structure. 17:869-881
Summary One major objective of structural genomics efforts, including the NIH-funded Protein Structure Initiative (PSI), has been to increase the structural coverage of protein sequence space. Here, we present the target selection strategy used durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b36944cc980879e1563f2919307a10
https://doi.org/10.1016/j.str.2009.03.015
https://doi.org/10.1016/j.str.2009.03.015