Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Benoit Fischer"'
Publikováno v:
Methods and Protocols, Vol 6, Iss 6, p 119 (2023)
Perturbation of angiogenesis is associated with a variety of diseases and pro- as well as antiangiogenic therapies are being actively explored. Additionally, unintended adverse drug effects on angiogenesis might lead to promotion of tumor progression
Externí odkaz:
https://doaj.org/article/446e8ce0abc34a028bd02639e6accb3e
Autor:
Myriam Lemmens, Benoit Fischer, Michael Zogg, Lindsey Rodrigues, Grainne Kerr, Alberto del Rio-Espinola, Fanny Schaeffer, Danilo Maddalo, Valerie Dubost, Alessandro Piaia, Arne Mueller, Ulla Plappert-Helbig, Ulrike Naumann, Jasmin Haegele, Alex Odermatt, Hans-Jörg Martus, Silvana Libertini
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 241-253 (2021)
Off-target editing is one of the main safety concerns for the use of CRISPR-Cas9 genome editing in gene therapy. These unwanted modifications could lead to malignant transformation, which renders tumorigenicity assessment of gene therapy products ind
Externí odkaz:
https://doaj.org/article/290bd942646a411a99a58b2d82349198
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005791 (2016)
DNA lesions are sensed by a network of proteins that trigger the DNA damage response (DDR), a signaling cascade that acts to delay cell cycle progression and initiate DNA repair. The Mediator of DNA damage Checkpoint protein 1 (MDC1) is essential for
Externí odkaz:
https://doaj.org/article/1a8b13e5ef244031a78fcd51060dd358
Autor:
Jeffrey D. Kearns, Paul Wassmann, Ufuk Olgac, Marie Fichter, Brigitte Christen, Tina Rubic-Schneider, Stephan Koepke, Benjamin Cochin de Billy, David Ledieu, Cedric Andre, Stuart Hawtin, Benoit Fischer, Francesca Moretti, Christian Hug, Alexander Bepperling, Barbara Brannetti, Celia Mendez-Garcia, Amanda Littlewood-Evans, Andreas Clemens, Cynthia L. Grosskreutz, Pawan Mehan, Robert L. Schmouder, Vito Sasseville, Dominique Brees, Anette C. Karle
Publikováno v:
Science Translational Medicine. 15
Immunogenicity against intravitreally administered brolucizumab has been previously described and associated with cases of severe intraocular inflammation, including retinal vasculitis/retinal vascular occlusion (RV/RO). The presence of antidrug anti
Autor:
Lindsey Rodrigues, Arne Mueller, Jasmin Haegele, Alberto Del Rio-Espinola, Silvana Libertini, Danilo Maddalo, Alex Odermatt, Benoit Fischer, Valerie Dubost, Alessandro Piaia, Myriam Lemmens, Ulla Plappert-Helbig, Grainne Kerr, Fanny Schaeffer, Ulrike Naumann, Hans-Jörg Martus, Michael Zogg
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 241-253 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 241-253 (2021)
Off-target editing is one of the main safety concerns for the use of CRISPR-Cas9 genome editing in gene therapy. These unwanted modifications could lead to malignant transformation, which renders tumorigenicity assessment of gene therapy products ind
Autor:
Veronica V. Rezelj, Audrey Fischer, Francesca Moretti, Romel Rosales, Olivier Schwartz, Jiankun Lyu, Francois Pognan, Andrew C. Kruse, Kris M. White, Marco Vignuzzi, Heiko Schadt, Ziyang Zhang, Henry R. O’Donnell, Michael Schotsaert, Kevan M. Shokat, Tia A. Tummino, Adolfo García-Sastre, Nevan J. Krogan, Jean-Rene Galarneau, Raveen Rathnasinghe, Blandine Monel, Benoit Fischer, Briana L. McGovern, Assaf Alon, Matthew J. O’Meara, Thomas Vallet, Brian K. Shoichet, Sonia Jangra, Laszlo Urban
Publikováno v:
Science (New York, N.Y.)
Science (New York, N.Y.), vol 373, iss 6554
Science
Science, 2021, 373 (6554), pp.541-547. ⟨10.1126/science.abi4708⟩
Science (New York, N.Y.), vol 373, iss 6554
Science
Science, 2021, 373 (6554), pp.541-547. ⟨10.1126/science.abi4708⟩
International audience; Repurposing drugs as treatments for COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning with sigma receptor ligands and expanding to other drugs fro
Autor:
Enrica Saponara, Carlos Penno, Vanessa Orsini, Zhong-Yi Wang, Audrey Fischer, Alexandra Aebi, Meztli L. Matadamas-Guzman, Virginie Brun, Benoit Fischer, Margaret Brousseau, Peter O'Donnell, Jonathan Turner, Alexandra Graff Meyer, Laura Bollepalli, Giovanni d’Ario, Guglielmo Roma, Walter Carbone, Stefano Annunziato, Michael Obrecht, Nicolau Beckmann, Chandra Saravanan, Arnaud Osmont, Philipp Tropberger, Shola M. Richards, Christel Genoud, Svenja Ley, Iwona Ksiazek, Florian Nigsch, Luigi M. Terracciano, Heiko S. Schadt, Tewis Bouwmeester, Jan S. Tchorz, Heinz Ruffner
Publikováno v:
The American journal of pathology.
The roof plate-specific spondin-leucine-rich repeat-containing G-protein-coupled receptor 4/5 (Lgr4/5)-zinc and ring finger 3/ring finger protein 43 module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation, but its impa
Autor:
Arnaud Osmont, Walter Carbone, Vanessa Orsini, Florian Nigsch, Jonathan J. Turner, Christel Genoud, Shola M Richards, Laura Bollepalli, Enrica Saponara, Svenja Ley, Zhong-Yi Wang, Giovanni d'Ario, Alexandra Aebi, Meztli L Matadamas Guzmán, Philipp Tropberger, Stefano Annunziato, Chandrassegar Saravanan, Benoit Fischer, Guglielmo Roma, Tewis Bouwmeester, Michael Obrecht, Jan S. Tchorz, Virginie Brun, Heinz Ruffner, Nicolau Beckmann, Carlos A. Penno, Margaret E. Brousseau, Peter O'Donnell, Alexandra Graff Meyer, Iwona Ksiazek, Luigi Terraciano
Background & AimsThe Rspo-Lgr4/5-Znrf3/Rnf43 module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation, but its impact on nonalcoholic fatty liver disease (NAFLD) remains unclear. We studied whether liver-specific loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a28cc1cd150989852141c4658c7ee558
https://doi.org/10.1101/2021.11.22.469602
https://doi.org/10.1101/2021.11.22.469602
Autor:
Francois Pognan, Laszlo Urban, Heiko Schadt, Veronica V. Rezelj, Adolfo Garcia-Sastre, Olivier Schwartz, Blandine Monel, Nevan J. Krogan, Audrey Fischer, Ziyang Zhang, Brian K. Shoichet, Assaf Alon, Matthew J. O’Meara, Benoit Fischer, Kevan M. Shokat, Tia A. Tummino, Kris M. White, Marco Vignuzzi, Francesca Moretti, Jiankun Lyu, Thomas Vallet, Henry R. O’Donnell, Andrew C. Kruse
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Repurposing drugs as treatments for COVID-19 has drawn much attention. A common strategy has been to screen for established drugs, typically developed for other indications, that are antiviral in cells or organisms. Intriguingly, most of the drugs th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9022a1070b6eea488945070d6619e143
https://doi.org/10.1101/2021.03.23.436648
https://doi.org/10.1101/2021.03.23.436648
Publikováno v:
PLoS Genetics
PLoS Genetics, Public Library of Science, 2016, 12 (2), pp.e1005791. ⟨10.1371/journal.pgen.1005791⟩
PLoS Genetics, Vol 12, Iss 2, p e1005791 (2016)
PLoS Genetics, 2016, 12 (2), pp.e1005791. ⟨10.1371/journal.pgen.1005791⟩
PLoS Genetics, Public Library of Science, 2016, 12 (2), pp.e1005791. ⟨10.1371/journal.pgen.1005791⟩
PLoS Genetics, Vol 12, Iss 2, p e1005791 (2016)
PLoS Genetics, 2016, 12 (2), pp.e1005791. ⟨10.1371/journal.pgen.1005791⟩
DNA lesions are sensed by a network of proteins that trigger the DNA damage response (DDR), a signaling cascade that acts to delay cell cycle progression and initiate DNA repair. The Mediator of DNA damage Checkpoint protein 1 (MDC1) is essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e47f3bd937c1f27832b686dfb9f752e
https://hal.archives-ouvertes.fr/hal-03450838
https://hal.archives-ouvertes.fr/hal-03450838