Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Benoit Destenaves"'
Autor:
Erika P Hamilton, Judy S Wang, Timothy Pluard, Aki Morikawa, E Claire Dees, Robert H Jones, Barbara Haley, Anne Armstrong, Adam L Cohen, Pamela Munster, Gail S Wright, Fadi Kayali, Lisa Cantagallo, Manav Korpal, Jenny Long, Jianjun Xiao, Benoit Destenaves, Lei Gao, Tarek Sahmoud, Antonio Gualberto, Dejan Juric
Publikováno v:
Cancer Research. 82:P1-17
Purpose: H3B-6545, a novel Selective ERα Covalent Antagonist (SERCA), inactivates both and wild-type and mutant ERα by targeting cysteine 530 and enforcing antagonist conformation. H3B-6545 demonstrated preclinical high activity in breast cancer mo
Autor:
Robert T. McCormack, Daniel Stetson, Dana E. Connors, J. Carl Barrett, Kenneth D. Cole, Steven P. Lund, Chris Karlovich, Thomas Forbes, P. Mickey Williams, Megan H. Cleveland, Laura M. Yee, Christie J. Lau, Cloud P. Paweletz, Gary J. Kelloff, Benoit Destenaves, Hua-Jun He, Susan M. Keating
Publikováno v:
JCO Precision Oncology
PURPOSEWe report the results from a Foundation for the National Institutes of Health Biomarkers Consortium project to address the absence of well-validated quality control materials (QCMs) for circulating tumor DNA (ctDNA) testing. This absence is co
Autor:
David P. Steensma, Lionel Ades, Ian W. Flinn, Rami S. Komrokji, Jaime Pérez de Oteyza, Peter L. Greenberg, Keisuke Kuida, Hetty E. Carraway, Huilan Yao, Antonio Gualberto, James M. Foran, Catherine C. Coombs, Benoit Destenaves, Ana Alfonso-Piérola, Xiaobin Yuan, Patricia Font, Jianjun Xiao, Andrew M. Brunner, Kun Yu, Eunice S. Wang, Catherine Scholz, Uwe Platzbecker, Michael B. Maris, Jay Yang, Malgorzata McMasters, Alyssa J. Marino, Guillermo Garcia-Manero, Jean Baptiste Micol, Juan M. Alonso-Dominguez, Martin Wermke, Sara Dar, H. Joachim Deeg, Felicitas Thol, Virginia M. Klimek, Richard Stone, Justin M. Watts, Vikram Gourineni, Justin Taylor, Lernik Ohanjanian, Aref Al-Kali
Publikováno v:
Leukemia
We conducted a phase I clinical trial of H3B-8800, an oral small molecule that binds Splicing Factor 3B1 (SF3B1), in patients with MDS, CMML, or AML. Among 84 enrolled patients (42 MDS, 4 CMML and 38 AML), 62 were red blood cell (RBC) transfusion dep
Autor:
Erika Hamilton, Manav Korpal, Jianjun Alan Xiao, Stephen R. D. Johnston, Timothy J. Pluard, J. Marc Pipas, Judy Sing-Zan Wang, Dejan Juric, Elizabeth Hnitecki, Lihua Yu, Catherine Rose Scholz, Lisa Cantagallo, Tarek Sahmoud, Benoit Destenaves, Lei Gao, Antonio Gualberto, Zhaojie Zhang
Publikováno v:
Journal of Clinical Oncology. 39:e13025-e13025
e13025 Background: H3B-6545, a highly Selective ERα Covalent Antagonist (SERCA), inactivates both wild-type and mutant ERα by targeting cysteine 530 and enforcing a unique antagonist conformation. At the dose of 450 mg daily, H3B-6545 has a managea
Phase I study of H3B-6527 in hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC)
Autor:
Anand Selvaraj, Yang Sheng-Shun, Ronald Gomez, Thomas Benjamin Karasic, Michael Fuchs, Samuel Le Sourd, Teresa Macarulla, Andres J. Muñoz Martín, Jianjun Alan Xiao, Wei Peng Yong, J. Marc Pipas, Richard S. Finn, Yoon-Koo Kang, Michael B. Sawyer, Benoit Destenaves, John C. Morris, Victor Moreno, Antonio Gualberto, Lipika Goyal, Li-Tzong Chen
Publikováno v:
Journal of Clinical Oncology. 39:4090-4090
4090 Background: Evidence suggests that hyperactivated fibroblast growth factor 4 (FGFR4) signaling pathway leads to enhanced tumor growth. Targeting FGFR4 may have therapeutic benefit in tumors with altered FGF19 signaling. A phase I study (NCT02834
Autor:
Stephen R. D. Johnston, Judy Sing-Zan Wang, Jianjun Alan Xiao, Benoit Destenaves, Gail Lynn Shaw Wright, Fadi Kayali, Aki Morikawa, Robert H. Jones, Manav Korpal, Elizabeth Claire Dees, Erika Hamilton, Timothy J. Pluard, Lei Gao, Adam L. Cohen, Anne C Armstrong, Antonio Gualberto, Barbara Haley, Dejan Juric, Pamela N. Munster, Jenny Long
Publikováno v:
Journal of Clinical Oncology. 39:1018-1018
1018 Background: H3B-6545, a selective, small molecule covalent antagonist of ERα demonstrated preclinical and preliminary clinical activity against ER+ breast cancer (Hamilton EP, SABCS, 2020). This study evaluated the activity and tolerability of
Autor:
Benoit Destenaves
Publikováno v:
Handbook of Biomarkers and Precision Medicine ISBN: 9780429202872
Handbook of Biomarkers and Precision Medicine
Handbook of Biomarkers and Precision Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb26680f4754462f338d2c754350214
https://doi.org/10.1201/9780429202872-27
https://doi.org/10.1201/9780429202872-27
Autor:
Erika P Hamilton, Judy S Wang, Timothy Pluard, Stephen Johnston, Aki Aki Morikawa, Claire E Dees, Robert H Jones, Barbara Haley, Anne Armstrong, Adam L Cohen, Pamela Munster, Gail Wright, Fadi Kayali, Manav Korpal, Lihua Yu, Lisa Cantagallo, Benoit Destenaves, Zhaojie Zhang, Lei Gao, Marc J Pipas, Tarek Sahmouud, Antonio Gualberto, Dejan Juric
Publikováno v:
Cancer Research. 81:PD8-06
Background: Addition of CDK 4/6 inhibitors to endocrine therapy has provided significant improvements in outcomes for patients (pts) with metastatic breast cancer (mBC). However, acquired resistance to front-line therapy remains a challenge, and resp
Autor:
Benoit Destenaves, Katie L. Raby, Emma Bell, Matthew J. Murray, Helen Brown, Ad J. M. Gillis, Martin A. Rijlaarsdam, James Nicholson, Nicholas Coleman, Leendert H. J. Looijenga
Publikováno v:
British Journal of Cancer
British Journal of Cancer, 114(2), 151-162. Nature Publishing Group
British Journal of Cancer, 114(2), 151-162. Nature Publishing Group
textabstractBackground:The current biomarkers alpha-fetoprotein and human chorionic gonadotropin have limited sensitivity and specificity for diagnosing malignant germ-cell tumours (GCTs). MicroRNAs (miRNAs) from the miR-371-373 and miR-302/367 clust
Autor:
Benoit Destenaves, Rob Hooft van Huijsduijnen, Peter E. Clayton, Andrew Whatmore, Iwona Pilecka
Publikováno v:
Trends in Endocrinology & Metabolism. 18:12-18
Our molecular understanding of growth hormone-induced signal transduction has improved significantly over the past decades. At the same time, human population genetics and the analysis of genetically engineered animals have led to the discovery of ge