Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Benoit Cox"'
Autor:
Benoit Cox, Patrick Barton, Reiner Class, Hannah Coxhead, Claude Delatour, Eric Gillent, Jamie Henshall, Emre M. Isin, Lloyd King, Jean-Pierre Valentin
Publikováno v:
Biomaterials and Biosystems, Vol 7, Iss , Pp 100054- (2022)
Human 3D liver microtissues/spheroids are powerful in vitro models to study drug-induced liver injury (DILI) but the small number of cells per spheroid limits the models’ usefulness to study drug metabolism. In this work, we scale up the number of
Externí odkaz:
https://doaj.org/article/4f84f1c7e9f24453a86a0742477c1d28
Autor:
Emma Laporte, Florian Hermans, Silke De Vriendt, Annelies Vennekens, Diether Lambrechts, Charlotte Nys, Benoit Cox, Hugo Vankelecom
Publikováno v:
eLife, Vol 11 (2022)
The pituitary represents the endocrine master regulator. In mouse, the gland undergoes active maturation immediately after birth. Here, we in detail portrayed the stem cell compartment of neonatal pituitary. Single-cell RNA-sequencing pictured an act
Externí odkaz:
https://doaj.org/article/0efcee480a6f48e3816e78f63c5b172b
Publikováno v:
Biopharmaceutics & Drug Disposition. 44:113-126
The blood-brain barrier (BBB) expresses a high abundance of transporters, particularly P-glycoprotein (P-gp), that regulate endogenous and exogenous molecule uptake and removal of waste. This review discusses key drug metabolism and pharmacokinetic c
Autor:
Charlotte Nys, Patrick Matthys, Adrian Janiszewski, Emma Laporte, Diether Lambrechts, Elodie Modave, Marie-Isabelle Garcia, Hiroto Kobayashi, Benoit Cox, Joel Chappell, Vincent Pasque, Florient Hermans, Hugo Vankelecom, Bert Malengier-Devlies, Annelies Vennekens
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury. The molecular mechanisms underlying this reaction are completely unknown. We applied single-cell transcriptomics to start unraveling the acute pituitary ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49dd5b500ecf3aa1376b85335bd344f
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/323041
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/323041
Autor:
Ignace Vergote, Bram Boeckx, Florian Hermans, Ziga Jan, Nina Maenhoudt, Anne-Sophie Van Rompuy, Matteo Boretto, Els Van Nieuwenhuysen, R. Heremans, Ingrid Arijs, Hugo Vankelecom, Charlotte Defraye, Dirk Timmerman, Diether Lambrechts, Benoit Cox
Publikováno v:
Article
Stem Cell Reports
Stem Cell Reports
Summary Ovarian cancer (OC) represents the most dismal gynecological cancer. Pathobiology is poorly understood, mainly due to lack of appropriate study models. Organoids, defined as self-developing three-dimensional in vitro reconstructions of tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97485e63af3898d7634751bcb9fec2c2
https://lirias.kuleuven.be/handle/123456789/653050
https://lirias.kuleuven.be/handle/123456789/653050
Autor:
Benjamin Beck, Hugo Vankelecom, Hiroshi Uji-i, Matteo Boretto, Annelies Vennekens, Emma Laporte, Alizée Vercauteren Drubbel, Indra Van Zundert, Benoit Cox, Heleen Roose, Charlotte Nys, Hiroto Kobayashi
Publikováno v:
Journal of Endocrinology, 240 (2
Journal of Endocrinology
Journal of Endocrinology
The pituitary is the master endocrine gland, harboring stem cells of which the phenotype and role remain poorly characterized. Here, we established organoids from mouse pituitary with the aim to generate a novel research model to study pituitary stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0747a7cb170d10c6a1137c2b68dfa3a
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/303170
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/303170
Autor:
Xinlong Luo, Lisa Perneel, Joris Vriens, Indra Van Zundert, Hilde Brems, Thomas D'Hooghe, Benoit Cox, Marc Ferrante, Nina Maenhoudt, Aurélie Hennes, Bram Boeckx, Diether Lambrechts, Carla Tomassetti, Dirk Timmerman, Hiroto Kobayashi, Arne Vanhie, Ignace Vergote, Bich Bui, Kian Peng Koh, Christel Meuleman, Matteo Boretto, Hiroshi Uji-i, Hugo Vankelecom, R. Heremans
Publikováno v:
Nature cell biology. 21(8)
Endometrial disorders represent a major gynaecological burden. Current research models fail to recapitulate the nature and heterogeneity of these diseases, thereby hampering scientific and clinical progress. Here we developed long-term expandable org
Autor:
Matteo Boretto, Conny Gysemans, Benoit Cox, Heleen Roose, Annelies Vennekens, Hugo Vankelecom
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2+ cells through diphtheria toxin (DT)-mediated ablation. DT treatment of adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571a807e41e98db88319ec799fa36b15
https://lirias.kuleuven.be/handle/123456789/604650
https://lirias.kuleuven.be/handle/123456789/604650
Autor:
Heleen, Roose, Benoit, Cox, Matteo, Boretto, Conny, Gysemans, Annelies, Vennekens, Hugo, Vankelecom
Publikováno v:
Scientific Reports
The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2+ cells through diphtheria toxin (DT)-mediated ablation. DT treatment of adult