Výsledky vyhledávání - "Benoit Bachand"

Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors

Autor: Benoit Bachand, Dimaio John, M. Arshad Siddiqui

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 9:913-918

A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have chemical diversity alpha to the lactam carbonyl and, when linked to electrophilic arginines, provide p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f13c51116ed8c9011e08e96e3fd0d8
https://doi.org/10.1016/s0960-894x(99)00130-4

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Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications

Autor: Sophie Levesque, Kent A. Berryman, M. Arshad Siddiqui, Jeremy J. Edmunds, Peter D. Winocour, John DiMaio, Annette Marian Doherty, Yves St-Denis, C.E. Augelli-Szafran, Benoit Bachand, Lorraine Leblond, Lakshmi S. Narasimhan, J. Ronald Rubin, Micheline Tarazi, J.R. Penvose-Yi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:3193-3198

Peptidomimetic inhibitors of general structure 1 have been prepared. Optimization of the binding affinities of these compounds through variation of the P3 hydrophobic residue is described. Selected substituted bicylic lactams displayed interesting ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197b252f0565e168178e927f9b2d1654
https://doi.org/10.1016/s0960-894x(98)00550-2

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Catalytic Asymmetric Synthesis of Quaternary Carbon Centers. Exploratory Investigations of Intramolecular Heck Reactions of (E)-α,β-Unsaturated 2-Haloanilides and Analogues To Form Enantioenriched Spirocyclic Products

Autor: Daniel J. Poon, Benoit Bachand, Atsuyuki Ashimori, Larry E. Overman

Publikováno v: Journal of the American Chemical Society. 120:6477-6487

The effect of chiral diphosphine structure, method of catalyst generation, reaction solvent, and HI scavenger on the formation of enantioenriched 3,3-disubstituted 2-oxindole 5 from asymmetric Heck cyclization of 4 was studied (eq 1). Depending upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb66ddafc338b5f6dc82e57bf0f5374e
https://doi.org/10.1021/ja980786p

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Catalytic Asymmetric Synthesis of Quaternary Carbon Centers. Exploratory Studies of Intramolecular Heck Reactions of (Z)-α,β-Unsaturated Anilides and Mechanistic Investigations of Asymmetric Heck Reactions Proceeding via Neutral Intermediates

Autor: and Larry E. Overman, Benoit Bachand, c Michael A. Calter, Atsuyuki Ashimori, Daniel J. Poon d, Steven P. Govek

Publikováno v: Journal of the American Chemical Society. 120:6488-6499

Intramolecular Heck reactions of seven (Z)-α,β-unsaturated 2-iodoanilides catalyzed by Pd−BINAP were surveyed using two reaction conditions: (1) silver-promoted cyclizations in the presence of 2 equiv of Ag3PO4 and (2) base-promoted cyclizations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ef36331d310cd08496ff86512d78307
https://doi.org/10.1021/ja980787h

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Article

Autor: Okba Saied, Benoit Bachand, James D Wuest

Publikováno v: Canadian Journal of Chemistry. 76:490-497

Carbonyl oxygen atoms have two formal lone pairs of electrons. In principle, both can be used simultaneously to form complexes with two or more Lewis acids. This multiple coordination promises to have a variety of interesting consequences; unfortunat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12d411be4ce43b11ae77f37cc8bf96cf
https://doi.org/10.1139/v98-047

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ChemInform Abstract: Catalytic Asymmetric Synthesis of Quaternary Carbon Centers. Exploratory Investigations of Intramolecular Heck Reactions of (E)-α,β-Unsaturated 2-Haloanilides and Analogues to Form Enantioenriched Spirocyclic Products

Autor: Benoit Bachand, Larry E. Overman, Daniel J. Poon, Atsuyuki Ashimori

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74565d460b2fb729da5e529814dee190
https://doi.org/10.1002/chin.199846130

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