Zobrazeno 1 - 10
of 464
pro vyhledávání: '"Benoit Viollet"'
Autor:
Marine Lanfranchi, Sozerko Yandiev, Géraldine Meyer-Dilhet, Salma Ellouze, Martijn Kerkhofs, Raphael Dos Reis, Audrey Garcia, Camille Blondet, Alizée Amar, Anita Kneppers, Hélène Polvèche, Damien Plassard, Marc Foretz, Benoit Viollet, Kei Sakamoto, Rémi Mounier, Cyril F. Bourgeois, Olivier Raineteau, Evelyne Goillot, Julien Courchet
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The cellular mechanisms underlying axonal morphogenesis are essential to the formation of functional neuronal networks. We previously identified the autism-linked kinase NUAK1 as a central regulator of axon branching through the control of m
Externí odkaz:
https://doaj.org/article/4e8f983c4969417aad556f0a4f0dc423
Autor:
Julia R.C. Nunes, Conor O’Dwyer, Peyman Ghorbani, Tyler K.T. Smith, Samarth Chauhan, Victoria Robert-Gostlin, Madison D. Girouard, Benoit Viollet, Marc Foretz, Morgan D. Fullerton
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100564- (2024)
Metabolic programming underpins inflammation and liver macrophage activation in the setting of chronic liver disease. Here, we sought to identify the role of an important metabolic regulator, AMP-activated protein kinase (AMPK), specifically within m
Externí odkaz:
https://doaj.org/article/01ecd99fcd564181b4e72710a742afcc
Autor:
Aurore Claude-Taupin, Pierre Isnard, Alessia Bagattin, Nicolas Kuperwasser, Federica Roccio, Biagina Ruscica, Nicolas Goudin, Meriem Garfa-Traoré, Alice Regnier, Lisa Turinsky, Martine Burtin, Marc Foretz, Marco Pontoglio, Etienne Morel, Benoit Viollet, Fabiola Terzi, Patrice Codogno, Nicolas Dupont
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Shear stress generated by urinary fluid flow is an important regulator of renal function. Its dysregulation is observed in various chronic and acute kidney diseases. Previously, we demonstrated that primary cilium-dependent autophagy allows
Externí odkaz:
https://doaj.org/article/e254472962f4442b9d2e6ee13c808669
Autor:
Calum Forteath, Ify Mordi, Raid Nisr, Erika J. Gutierrez-Lara, Noor Alqurashi, Iain R. Phair, Amy R. Cameron, Craig Beall, Ibrahim Bahr, Mohapradeep Mohan, Aaron K.F. Wong, Adel Dihoum, Anwar Mohammad, Colin N.A. Palmer, Douglas Lamont, Kei Sakamoto, Benoit Viollet, Marc Foretz, Chim C. Lang, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101750- (2023)
Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. Methods: We used cellular approaches, inc
Externí odkaz:
https://doaj.org/article/6034f1d72e63418cb69e689338644a8d
Autor:
Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, Franck Polleux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Loss of excitatory synapses occur prior to the formation of amyloid plaques in Alzheimer’s disease. Here the authors show in an animal model that the loss of synapses induced by amyloid-beta oligomers requires over-activation of a stress-response p
Externí odkaz:
https://doaj.org/article/e4cca8864343441c862cd2169b11e9ee
Autor:
Javier Moral-Sanz, Sophronia A. Lewis, Sandy MacMillan, Marco Meloni, Heather McClafferty, Benoit Viollet, Marc Foretz, Jorge del-Pozo, A. Mark Evans
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
AMPK modulates idiopathic and hypoxic pulmonary hypertension in adults, largely via unknown mechanisms. Here, the authors show that AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new born and premature death in mice
Externí odkaz:
https://doaj.org/article/3376d21907c9443c9accb7061aa04379
Autor:
Iain R. Phair, Raid B. Nisr, Andrew J.M. Howden, Magdalena Sovakova, Noor Alqurashi, Marc Foretz, Douglas Lamont, Benoit Viollet, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101661- (2023)
Objective: Previous mechanistic studies on immunometabolism have focused on metabolite-based paradigms of regulation, such as itaconate. Here, we, demonstrate integration of metabolite and kinase-based immunometabolic control by AMP kinase. Methods:
Externí odkaz:
https://doaj.org/article/9997821d5e474d32b6b62c53f148b945
Autor:
Anne Garnier, Jérôme Leroy, Claudine Deloménie, Philippe Mateo, Benoit Viollet, Vladimir Veksler, Mathias Mericskay, Renée Ventura-Clapier, Jérôme Piquereau
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0292015 (2023)
The beta-adrenergic system is a potent stimulus for enhancing cardiac output that may become deleterious when energy metabolism is compromised as in heart failure. We thus examined whether the AMP-activated protein kinase (AMPK) that is activated in
Externí odkaz:
https://doaj.org/article/ac04777b61eb411db0fec894cce101ae
Autor:
Kevin N. Su, Yina Ma, Marine Cacheux, Zeki Ilkan, Nour Raad, Grace K. Muller, Xiaohong Wu, Nicole Guerrera, Stephanie L. Thorn, Albert J. Sinusas, Marc Foretz, Benoit Viollet, Joseph G. Akar, Fadi G. Akar, Lawrence H. Young
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Metabolic stress is an important cause of pathological atrial remodeling and atrial fibrillation. AMPK is a ubiquitous master metabolic regulator, yet its biological function in the atria is poorly understood in both health and disease. We investigat
Externí odkaz:
https://doaj.org/article/89a8b570681a43d5b439e41dbe042fb5
Autor:
Nicholas D. LeBlond, Peyman Ghorbani, Conor O'Dwyer, Nia Ambursley, Julia R.C. Nunes, Tyler K.T. Smith, Natasha A. Trzaskalski, Erin E. Mulvihill, Benoit Viollet, Marc Foretz, Morgan D. Fullerton
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1697-1706 (2020)
The dysregulation of myeloid-derived cell metabolism can drive atherosclerosis. AMP-activated protein kinase (AMPK) controls various aspects of macrophage dynamics and lipid homeostasis, which are important during atherogenesis. Using LysM-Cre to dri
Externí odkaz:
https://doaj.org/article/f36517f379a741489a56e4fcfe0c1791