Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Benoit, Chabot"'
Autor:
Cunjie Chang, Lina Li, Ling Su, Fan Yang, Quanxiu Zha, Mengqing Sun, Lin Tao, Menglan Wang, Kangli Song, Liangyu Jiang, Haojin Gao, Yexin Liang, Chao Xu, Caiyu Yong, Minmin Wang, Jiacheng Huang, Jing Liu, Weiwei Jin, Wenyuan Lv, Heng Dong, Qian Li, Fangtian Bu, Shuanghong Yan, Haoxiang Qi, Shujuan Zhao, Yingshuang Zhu, Yu Wang, Junping Shi, Yiting Qiao, Jian Xu, Benoit Chabot, Jianxiang Chen
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract RNA splicing is a dynamic molecular process in response to environmental stimuli and is strictly regulated by the spliceosome. Sm proteins, constituents of the spliceosome, are key components that mediate splicing reactions; however, their p
Externí odkaz:
https://doaj.org/article/c2bead1b603b40eaa1080fd7c4825161
Autor:
Subha Dahal, Kiera Clayton, Terek Been, Raphaële Fernet-Brochu, Alonso Villasmil Ocando, Ahalya Balachandran, Mikaël Poirier, Rebecca Kaddis Maldonado, Lulzim Shkreta, Kayluz Frias Boligan, Furkan Guvenc, Fariha Rahman, Donald Branch, Brendan Bell, Benoit Chabot, Scott D. Gray-Owen, Leslie J. Parent, Alan Cochrane
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-25 (2022)
Plain Language Summary Identifying cellular factors that regulate HIV-1 RNA processing provides important insights into novel strategies to control this infection. Different members of the SR kinase family have distinct roles in regulating virus expr
Externí odkaz:
https://doaj.org/article/f6c59f5364bf49b0a2fb808840fdf7ed
Autor:
Cunjie Chang, Muthukumar Rajasekaran, Yiting Qiao, Heng Dong, Yu Wang, Hongping Xia, Amudha Deivasigamani, Minjie Wu, Karthik Sekar, Hengjun Gao, Mengqing Sun, Yuqin Niu, Qian Li, Lin Tao, Zhen Yan, Menglan Wang, Shasha Chen, Shujuan Zhao, Dajing Chen, Lina Li, Fan Yang, Haojin Gao, Baodong Chen, Ling Su, Liang Xu, Ye Chen, Veerabrahma Pratap Seshachalam, Gongxing Chen, Jayantha Gunaratne, Wanjin Hong, Junping Shi, Gongying Chen, David S. Grierson, Benoit Chabot, Tian Xie, Kam Man Hui, Jianxiang Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Alternative splicing is dysregulated in hepatocellular carcinoma. Here, the authors investigate the role of the splice variant of Splicing Regulatory Glutamic Acid and Lysine Rich Protein 1 (SREK1) and its upstream regulator, Serine/arginine-rich spl
Externí odkaz:
https://doaj.org/article/899e96a6dffd4ad49c98b29c783e660e
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Protein phosphorylation constitutes a major post-translational modification that critically regulates the half-life, intra-cellular distribution, and activity of proteins. Among the large number of kinases that compose the human kinome tree, those ta
Externí odkaz:
https://doaj.org/article/d9d3089ca40b435abf89cc7aa9fa72c8
Autor:
Hélène Chabrolles, Héloïse Auclair, Serena Vegna, Thomas Lahlali, Caroline Pons, Maud Michelet, Yohann Couté, Lucid Belmudes, Gilliane Chadeuf, Yujin Kim, Ariel Di Bernardo, Pascal Jalaguier, François-Loïc Cosset, Floriane Fusil, Michel Rivoire, Lee D Arnold, Uri Lopatin, Christophe Combet, Fabien Zoulim, David Grierson, Benoit Chabot, Julie Lucifora, David Durantel, Anna Salvetti
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008593 (2020)
Despite the existence of a preventive vaccine, chronic infection with Hepatitis B virus (HBV) affects more than 250 million people and represents a major global cause of hepatocellular carcinoma (HCC) worldwide. Current clinical treatments, in most o
Externí odkaz:
https://doaj.org/article/151d937cb76042be9e95646ac4073046
Autor:
Michaël Sage, Wendy See, Stéphanie Nault, Christophe Morin, Christina Michalski, Benoit Chabot, Sofia Marouan, Pascal M. Lavoie, Philippe Micheau, Jean-Paul Praud, Étienne Fortin-Pellerin
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Animal experiments suggest that total liquid ventilation (TLV) induces less ventilator-induced lung injury (VILI) than conventional mechanical gas ventilation. However, TLV parameters that optimally minimize VILI in newborns remain unknown. Our objec
Externí odkaz:
https://doaj.org/article/422dd4464b6c41e78289375b98318d5a
Autor:
Sami Nourreddine, Geneviève Lavoie, Justine Paradis, Khaled Ben El Kadhi, Antoine Méant, Léo Aubert, Benoit Grondin, Patrick Gendron, Benoit Chabot, Michel Bouvier, Sébastien Carreno, Philippe P. Roux
Publikováno v:
Cell Reports, Vol 31, Iss 7, Pp - (2020)
Summary: In human cells, the expression of ∼1,000 genes is modulated throughout the cell cycle. Although some of these genes are controlled by specific transcriptional programs, very little is known about their post-transcriptional regulation. Here
Externí odkaz:
https://doaj.org/article/9c3341b5819a4f42a2c8f5bed71f24df
The transcription factor c-Jun inhibits RBM39 to reprogram pre-mRNA splicing during genotoxic stress
Autor:
Florence Lemaitre, Fatima Chakrama, Tina O’Grady, Olivier Peulen, Gilles Rademaker, Adeline Deward, Benoit Chabot, Jacques Piette, Alain Colige, Charles Lambert, Franck Dequiedt, Yvette Habraken
Publikováno v:
Nucleic Acids Research. 50:12768-12789
Genotoxic agents, that are used in cancer therapy, elicit the reprogramming of the transcriptome of cancer cells. These changes reflect the cellular response to stress and underlie some of the mechanisms leading to drug resistance. Here, we profiled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058d60ec3fe22f8de2cce5b2f9dbf718
https://doi.org/10.1093/nar/gkac1130
https://doi.org/10.1093/nar/gkac1130
Autor:
Subha Dahal, Ran Cheng, Peter K. Cheung, Terek Been, Ramy Malty, Melissa Geng, Sarah Manianis, Lulzim Shkreta, Shahrazad Jahanshahi, Johanne Toutant, Rose Chan, Sean Park, Mark A. Brockman, Mohan Babu, Samira Mubareka, Karen Mossman, Arinjay Banerjee, Scott Gray-Owen, Martha Brown, Walid A. Houry, Benoit Chabot, David Grierson, Alan Cochrane
Publikováno v:
Viruses, Vol 14, Iss 1, p 60 (2021)
Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 a
Externí odkaz:
https://doaj.org/article/1c76f49ace8b4a22bb54cfbd594bd88c
Autor:
Philippe Cloutier, Christian Poitras, Mathieu Durand, Omid Hekmat, Émilie Fiola-Masson, Annie Bouchard, Denis Faubert, Benoit Chabot, Benoit Coulombe
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The R2TP/Prefoldin-like cochaperone complex is involved in the assembly of a number of protein complexes. Here the authors provide evidence that RUVBL1/RUVBL2, subunits of that cochaperone complex, directly interact with ZNHIT2 to regulate assembly o
Externí odkaz:
https://doaj.org/article/0cf7d9678f7044719db9e7b1c662a6e5