Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Benoît Viollet"'
Autor:
Chloé Philippe, Benoît Pinson, Jim Dompierre, Véronique Pantesco, Benoît Viollet, Bertrand Daignan-Fornier, Michel Moenner
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 6, Pp 555-562 (2018)
AICAR (Acadesine) is a pharmacological precursor of purine nucleotide biosynthesis with anti-tumoral properties. Although recognized as an AMP mimetic activator of the protein kinase AMPK, the AICAR monophosphate derivative ZMP was also shown to medi
Externí odkaz:
https://doaj.org/article/f8b13ada0770436c8378f60106b2ad78
Autor:
Yassine Sakar, Corinne Nazaret, Philippe Lettéron, Amal Ait Omar, Mathilde Avenati, Benoît Viollet, Robert Ducroc, André Bado
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7935 (2009)
BACKGROUND AND AIMS: The small intestine is the major site of absorption of dietary sugars. The rate at which they enter and exit the intestine has a major effect on blood glucose homeostasis. In this study, we determine the effects of luminal leptin
Externí odkaz:
https://doaj.org/article/fded59a0b5504988bc2c37216dddd789
Autor:
Marine Lanfranchi, Sozerko Yandiev, Géraldine Meyer-Dilhet, Salma Ellouze, Martijn Kerkhofs, Raphael Dos Reis, Audrey Garcia, Camille Blondet, Alizée Amar, Anita Kneppers, Hélène Polvèche, Damien Plassard, Marc Foretz, Benoit Viollet, Kei Sakamoto, Rémi Mounier, Cyril F. Bourgeois, Olivier Raineteau, Evelyne Goillot, Julien Courchet
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The cellular mechanisms underlying axonal morphogenesis are essential to the formation of functional neuronal networks. We previously identified the autism-linked kinase NUAK1 as a central regulator of axon branching through the control of m
Externí odkaz:
https://doaj.org/article/4e8f983c4969417aad556f0a4f0dc423
Autor:
Julia R.C. Nunes, Conor O’Dwyer, Peyman Ghorbani, Tyler K.T. Smith, Samarth Chauhan, Victoria Robert-Gostlin, Madison D. Girouard, Benoit Viollet, Marc Foretz, Morgan D. Fullerton
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100564- (2024)
Metabolic programming underpins inflammation and liver macrophage activation in the setting of chronic liver disease. Here, we sought to identify the role of an important metabolic regulator, AMP-activated protein kinase (AMPK), specifically within m
Externí odkaz:
https://doaj.org/article/01ecd99fcd564181b4e72710a742afcc
Autor:
Aurore Claude-Taupin, Pierre Isnard, Alessia Bagattin, Nicolas Kuperwasser, Federica Roccio, Biagina Ruscica, Nicolas Goudin, Meriem Garfa-Traoré, Alice Regnier, Lisa Turinsky, Martine Burtin, Marc Foretz, Marco Pontoglio, Etienne Morel, Benoit Viollet, Fabiola Terzi, Patrice Codogno, Nicolas Dupont
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Shear stress generated by urinary fluid flow is an important regulator of renal function. Its dysregulation is observed in various chronic and acute kidney diseases. Previously, we demonstrated that primary cilium-dependent autophagy allows
Externí odkaz:
https://doaj.org/article/e254472962f4442b9d2e6ee13c808669
Autor:
Mario D. Cordero, Benoit Viollet
AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, inclu
Autor:
Calum Forteath, Ify Mordi, Raid Nisr, Erika J. Gutierrez-Lara, Noor Alqurashi, Iain R. Phair, Amy R. Cameron, Craig Beall, Ibrahim Bahr, Mohapradeep Mohan, Aaron K.F. Wong, Adel Dihoum, Anwar Mohammad, Colin N.A. Palmer, Douglas Lamont, Kei Sakamoto, Benoit Viollet, Marc Foretz, Chim C. Lang, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101750- (2023)
Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. Methods: We used cellular approaches, inc
Externí odkaz:
https://doaj.org/article/6034f1d72e63418cb69e689338644a8d
Autor:
Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, Franck Polleux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Loss of excitatory synapses occur prior to the formation of amyloid plaques in Alzheimer’s disease. Here the authors show in an animal model that the loss of synapses induced by amyloid-beta oligomers requires over-activation of a stress-response p
Externí odkaz:
https://doaj.org/article/e4cca8864343441c862cd2169b11e9ee
Autor:
Javier Moral-Sanz, Sophronia A. Lewis, Sandy MacMillan, Marco Meloni, Heather McClafferty, Benoit Viollet, Marc Foretz, Jorge del-Pozo, A. Mark Evans
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
AMPK modulates idiopathic and hypoxic pulmonary hypertension in adults, largely via unknown mechanisms. Here, the authors show that AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new born and premature death in mice
Externí odkaz:
https://doaj.org/article/3376d21907c9443c9accb7061aa04379
Autor:
Iain R. Phair, Raid B. Nisr, Andrew J.M. Howden, Magdalena Sovakova, Noor Alqurashi, Marc Foretz, Douglas Lamont, Benoit Viollet, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101661- (2023)
Objective: Previous mechanistic studies on immunometabolism have focused on metabolite-based paradigms of regulation, such as itaconate. Here, we, demonstrate integration of metabolite and kinase-based immunometabolic control by AMP kinase. Methods:
Externí odkaz:
https://doaj.org/article/9997821d5e474d32b6b62c53f148b945