The melanoma tumor glyco-code impacts human dendritic cells’ functionality and dictates clinical outcomes

Autor: Eleonora Sosa Cuevas, Benoît Roubinet, Stephane Mouret, Michel Thépaut, Florence de Fraipont, Julie Charles, Franck Fieschi, Ludovic Landemarre, Laurence Chaperot, Caroline Aspord

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Subversion of immunity is a hallmark of cancer development. Dendritic cells (DCs) are strategic immune cells triggering anti-tumor immune responses, but tumor cells exploit their versatility to subvert their functions. Tumor cells harbor unusual glyc

Externí odkaz: https://doaj.org/article/b9faa0146bf546a7b65654565ef5bd16

Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists

Autor: Leila Mousavifar, Meysam Sarshar, Clarisse Bridot, Daniela Scribano, Cecilia Ambrosi, Anna Teresa Palamara, Gérard Vergoten, Benoît Roubinet, Ludovic Landemarre, Julie Bouckaert, René Roy

Publikováno v: Pharmaceutics, Vol 15, Iss 2, p 527 (2023)

Selective antiadhesion antagonists of Uropathogenic Escherichia coli (UPEC) type-1 Fimbrial adhesin (FimH) are attractive alternatives for antibiotic therapies and prophylaxes against acute or recurrent urinary tract infections (UTIs) caused by UPECs

Externí odkaz: https://doaj.org/article/6aea907d3db0457581b05bbebb2f3810

Human galectin-1 and galectin-3 promote Tropheryma whipplei infection

Autor: Diyoly Ayona, Sandra Madariaga Zarza, Ludovic Landemarre, Benoît Roubinet, Philippe Decloquement, Didier Raoult, Pierre-Edouard Fournier, Benoit Desnues

Publikováno v: Gut Microbes, Vol 13, Iss 1 (2021)

Tropheryma whipplei, is an actinobacterium that causes different infections in humans, including Whipple’s disease. The bacterium infects and replicates in macrophages, leading to a Th2-biased immune response. Previous studies have shown that T. wh

Externí odkaz: https://doaj.org/article/49838f6fcd334465a757735d355fa12b

Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors

Autor: Eva-Maria Krammer, Clarisse Bridot, Sonia Serna, Begoña Echeverria, Shubham Semwal, Benoît Roubinet, Kim van Noort, Ruud H.P. Wilbers, Gleb Bourenkov, Jérôme de Ruyck, Ludovic Landemarre, Niels Reichardt, Julie Bouckaert

Publikováno v: The journal of biological chemistry 299(5), 104627 (2023). doi:10.1016/j.jbc.2023.104627
Journal of Biological Chemistry, 299(5)
Journal of Biological Chemistry 299 (2023) 5

The journal of biological chemistry 299(5), 104627 (2023). doi:10.1016/j.jbc.2023.104627
The FimH type-1 fimbrial adhesin allows pathogenic Escherichia coli to adhere to glycoproteins in the epithelial linings of human bladder and intestinal tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cac337f2eca79324ae7b22e49023d36

Polyvalent Transition-State Analogues of Sialyl Substrates Strongly Inhibit Bacterial Sialidases

Autor: Amélie Saumonneau, Coralie Assailly, Benoît Roubinet, Franck Daligault, Ludovic Landemarre, Francesca François, Cyrille Grandjean, Laurent Fontaine, Sagrario Pascual, paul lottin, Eva-Maria Krammer, frederica vena, Sébastien G. Gouin, David Deniaud, Véronique Montembault, Charles Tellier, Clarisse Bridot, Dimitri Alvarez-Dorta, Julie Bouckaert

Publikováno v: Chemistry – A European Journal
Chemistry-A European Journal
Chemistry-A European Journal, 2020, ⟨10.1002/chem.202004672⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.202004672⟩

Bacterial sialidases (SA) are validated drug targets expressed by common human pathogens such as Streptococcus pneumoniae, Vibrio cholerae, or Clostridium perfringens. Noncovalent inhibitors of bacterial SA capable of reaching the submicromolar level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e2ed2352152fdbb4d1ae65f567bc10