Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Benoît Métayer"'
1
Complementary Site‐Selective Halogenation of Nitrogen‐Containing (Hetero)Aromatics with Superacids
Autor: Omar Karam, Fabien Zunino, Agnès Martin-Mingot, Sébastien Thibaudeau, Alexander Mamontov, Benoît Métayer, Fodil Bouazza
Publikováno v: Chemistry – A European Journal. 26:10411-10416
Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720171dd4ef57fac7c746ef21eb22f92
https://doi.org/10.1002/chem.202000902
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2
Cationic polycyclization of ynamides: building up molecular complexity
Autor: Sébastien Thibaudeau, Hwai-Chien Chan, Phidéline Gérard, Naima Mokhtari, Cédric Theunissen, Nicolas Henry, Christian Bachmann, Agnès Martin-Mingot, Morgan Lecomte, Jérôme Marrot, Benoît Métayer, Guillaume Compain, Gwilherm Evano
Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2017, 15 (20), pp.4399-4416. ⟨10.1039/C7OB00850C⟩
Polycyclization reactions are among the most efficient synthetic tools for the synthesis of complex, polycyclic molecules in a single operation from simple starting materials. We report in this manuscript a full account on the discovery and developme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3658db6690c8b7bfa9241651924e35
https://doi.org/10.1039/c7ob00850c
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3
Fluoroenesulfonamides: N-Sulfonylurea Isosteres Showing Nanomolar Selective Cancer-Related Transmembrane Human Carbonic Anhydrase Inhibition
Autor: Claudiu T. Supuran, Sébastien Thibaudeau, Agnès Mingot, Andrea Angeli, Benoît Métayer, Gwilherm Evano, Kévin Jouvin
Publikováno v: Journal of enzyme inhibition and medicinal chemistry, 33
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2018, 33 (1), pp.804-808. ⟨10.1080/14756366.2018.1461097⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 804-808 (2018)
After hydrofluorination of ynesulphonamides in superacid or in the presence of hydrofluoric acid/base reagents, a series of α-fluoroenamides has been synthesised and tested for the inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms. This stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40a1aa335b0c4245687f89be3a2286f
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/269287
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4
A Journey in the Chemistry of Ynamides: From Synthesis to Applications
Autor: Nicolas Henry, Kévin Jouvin, Ganesan Karthikeyan, Charles S. Demmer, Bastien Michelet, Jianjun Wang, Agnès Martin-Mingot, Cédric Theunissen, Morgan Lecomte, Antoine Nitelet, Jérémy Heimburger, Benoît Métayer, Anouar Laouiti, Alexis Coste, Nicolas Blanchard, Guillaume Compain, Wafa Gati, Sébastien Thibaudeau, Gwilherm Evano, Maxence Zarca, Céline Guissart, Chunyang Zhang
Publikováno v: Chemistry Letters
Chemistry Letters, Chemical Society of Japan, 2016, 45 (6), pp.574-585. ⟨10.1246/cl.160260⟩
Due to their combined stability and peculiar reactivity, ynamides have emerged as remarkably useful building blocks for chemical synthesis. The development of general and robust methods for their preparation resulted in a massive interest for their c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c513c6c72c07f4230600b783fa2c77f3
https://hal.archives-ouvertes.fr/hal-03007853
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6
Chemo- and Stereoselective Synthesis of Fluorinated Enamides from Ynamides in HF/Pyridine: Second-Generation Approach to Potent Ureas Bioisosteres
Autor: Guillaume Compain, Jerome Marrot, Gwilherm Evano, Sébastien Thibaudeau, Christian Bachmann, Kévin Jouvin, Benoît Métayer, Agnès Martin-Mingot
Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2015, 80 pp. 3397-3410. ⟨10.1021/jo502699y⟩
International audience; (E)- and (Z)-alpha-fluoroenamides could be easily prepared with high levels of chemo- and regioselectivities by hydrofluorination of readily available ynamides with HF/pyridine. The scope and limitations of this new process fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23018e9799448f77886153855e2ec80
https://hal.archives-ouvertes.fr/hal-01360121
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7
ChemInform Abstract: Keteniminium Ion-Initiated Cascade Cationic Polycyclization
Autor: Cédric Theunissen, Sébastien Thibaudeau, Jerome Marrot, Nicolas Henry, Guillaume Compain, Gwilherm Evano, Benoît Métayer, Agnès Martin-Mingot
Publikováno v: ChemInform. 46
A novel and efficient keteniminium-initiated cationic polycyclization is reported. This reaction, which only requires triflic acid or bistriflimide as promoters, affords a straightforward entry to polycyclic nitrogen heterocycles possessing up to thr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cf1a3f24fbb57555b42fa2fe0016efd
https://doi.org/10.1002/chin.201515206
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9
Clicked Cinnamic/Caffeic Esters and Amides as Radical Scavengers and 5-Lipoxygenase Inhibitors
Autor: Jacques Jean-François, Benoît Métayer, Luc H. Boudreau, Dany Desjardins, Natalie A. Levesque, Samuel J. Poirier, Jérémie A. Doiron, Mohamed Touaibia, Marc E. Surette, Ryan Richard
Publikováno v: International Journal of Medicinal Chemistry, Vol 2014 (2014)
International Journal of Medicinal Chemistry
5-Lipoxygenase (5-LO) is the key enzyme responsible for the conversion of arachidonic acid to leukotrienes, a class of lipid mediators implicated in inflammatory disorders. In this paper, we describe the design, synthesis, and preliminary activity st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4682c897509942095978098e53956d70
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10
Superacid synthesized tertiary benzenesulfonamides and benzofuzed sultams act as selective hCA IX inhibitors: toward understanding a new mode of inhibition by tertiary sulfonamides
Autor: Benoît Métayer, Claudiu T. Supuran, Sébastien Thibaudeau, Agnès Martin-Mingot, Daniella Vullo
Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2013, 11 (43), pp.7540-7549. ⟨10.1039/c3ob41538d⟩
Organic & Biomolecular Chemistry; Vol 11
Organic & Biomolecular Chemistry
International audience; A series of tertiary (fluorinated) benzenesulfonamides was synthesized in superacid HF-SbF5. To circumvent the problem of the in situ iminium ion formation, proved by low temperature NMR experiments, a tandem superacid catalys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac66b0f40d75fff52b3b555ef1c06196
https://hal.archives-ouvertes.fr/hal-00964957
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