Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Benny J. Evison"'
Autor:
Jounghyun H. Lee, Kevin L. Shores, Jason J. Breithaupt, Caleb S. Lee, Daniella M. Fodera, Jennifer B. Kwon, Adarsh R. Ettyreddy, Kristin M. Myers, Benny J. Evison, Alexandra K. Suchowerska, Charles A. Gersbach, Kam W. Leong, George A. Truskey
Publikováno v:
APL Bioengineering, Vol 7, Iss 4, Pp 046103-046103-15 (2023)
Atherosclerosis is a primary precursor of cardiovascular disease (CVD), the leading cause of death worldwide. While proprotein convertase subtilisin/kexin 9 (PCSK9) contributes to CVD by degrading low-density lipoprotein receptors (LDLR) and altering
Externí odkaz:
https://doaj.org/article/f6d0b5cc6b244d04bac23d3123f01c78
Autor:
Alexandra K. Suchowerska, Geurt Stokman, James T. Palmer, Phillip A. Coghlan, Elsbet J. Pieterman, Nanda Keijzer, Gilles Lambert, Kevin Chemello, Ali K. Jaafar, Jasneet Parmar, Liping Yan, Yingtao Tong, Lin Mu, Hans M.G. Princen, James Bonnar, Benny J. Evison
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 11, Pp 100293- (2022)
Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the
Externí odkaz:
https://doaj.org/article/a8352bacd19e43b9a0446b8b8c352c9b
Autor:
Oula C. Mansour, Abraham Nudelman, Ada Rephaeli, Don R. Phillips, Suzanne M. Cutts, Benny J. Evison
Publikováno v:
Cancer Chemotherapy and Pharmacology. 89:773-784
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb5e36acd66c676857317f6b24b4a17
https://doi.org/10.1007/s00280-022-04435-1
https://doi.org/10.1007/s00280-022-04435-1
Autor:
Oula C, Mansour, Abraham, Nudelman, Ada, Rephaeli, Don R, Phillips, Suzanne M, Cutts, Benny J, Evison
Publikováno v:
Cancer chemotherapy and pharmacology. 89(6)
Pixantrone is a synthetic aza-anthracenedione currently used in the treatment of non-Hodgkin's lymphoma. The drug is firmly established as a poison of the nuclear enzyme topoisomerase II, however, pixantrone can also generate covalent drug-DNA adduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::229458ca9d75d78a77adf2e3d6bb47df
https://pubmed.ncbi.nlm.nih.gov/35460360
https://pubmed.ncbi.nlm.nih.gov/35460360
Autor:
Keith G. Watson, Benny J. Evison, Brad E. Sleebs, Don R. Phillips, Jelena Medan, Suzanne M. Cutts, Kurt Lackovic
Publikováno v:
Bioorganicmedicinal chemistry letters. 35
Current techniques for the identification of DNA adduct-inducing and DNA interstrand crosslinking agents include electrophoretic crosslinking assays, electrophoretic gel shift assays, DNA and RNA stop assays, mass spectrometry-based methods and 32P-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ae5ce5bb8656e0213c964940bc8181
https://pubmed.ncbi.nlm.nih.gov/33486050
https://pubmed.ncbi.nlm.nih.gov/33486050
Autor:
Kodai Hara, Nigus D. Ambaye, Sotaro Kikuchi, Benny J. Evison, Ezelle T. McDonald, Hiroshi Hashimoto, Richard J. Heath, Naoaki Fujii, Youming Shao, Murugendra Vanarotti, Akira Inoue, Marcelo Actis
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:4339-4346
DNA interstrand crosslink (ICL) repair (ICLR) has been implicated in the resistance of cancer cells to ICL-inducing chemotherapeutic agents. Despite the clinical significance of ICL-inducing chemotherapy, few studies have focused on developing small-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902003331aa280b49764fea9680eac33
https://doi.org/10.1016/j.bmc.2016.07.026
https://doi.org/10.1016/j.bmc.2016.07.026
Autor:
Graham E. Kelly, Qing Zhu, James T. Palmer, Kévin Chemello, James Bonnar, Ian Dixon, Benny J. Evison, Alexandra K. Suchowerska, Yanfen Teng, Anuj Kumar Rathi, Jun Zeng, Jie Wang, Brice Nativel, Wei Tang, Sanjay Kumar, Gilles Lambert, Yanfeng Xu, Herbert R. Treutlein, Jasneet Parmar
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115344
Proprotein convertase (PC) subtilisin kexin type 9 (PCSK9) inhibits the clearance of low density lipoprotein (LDL) cholesterol from plasma by directly interacting with the LDL receptor (LDLR). As the interaction promotes elevated plasma LDL cholester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccaaa8a9b49658c669a5f4770d4dfac
https://doi.org/10.1016/j.bmc.2020.115344
https://doi.org/10.1016/j.bmc.2020.115344
Autor:
Brad E. Sleebs, Benny J. Evison, Paul P. Pumuye, Jelena Medan, Celine Kelso, Suzanne M. Cutts, Don R. Phillips, J. Grant Collins, Keith G. Watson, Shyam K. Konda
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115260
Mitoxantrone is an anticancer anthracenedione that can be activated by formaldehyde to generate covalent drug-DNA adducts. Despite their covalent nature, these DNA lesions are relatively labile. It was recently established that analogues of mitoxantr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff843e1e50e3195bb5a68e5e9272cf8e
https://doi.org/10.1016/j.bmc.2019.115260
https://doi.org/10.1016/j.bmc.2019.115260
Autor:
Ezelle T. McDonald, Murugendra Vanarotti, Richard J. Heath, Youming Shao, Akira Inoue, Benny J. Evison, Naoaki Fujii, Marcelo Actis
Publikováno v:
Bioorganicmedicinal chemistry. 26(9)
REV1 protein is a mutagenic DNA damage tolerance (DDT) mediator and encodes two ubiquitin-binding motifs (i.e., UBM1 and UBM2) that are essential for the DDT function. REV1 interacts with K164-monoubiquitinated PCNA (UbPCNA) in cells upon DNA-damagin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b070e63bd75b5db88499bdb1c9bd40e2
https://pubmed.ncbi.nlm.nih.gov/29598900
https://pubmed.ncbi.nlm.nih.gov/29598900
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:6912-6921
Cells have evolved complex biochemical pathways for DNA interstrand crosslink (ICL) removal. Despite the chemotherapeutic importance of ICL repair, there have been few attempts to identify which mechanistic DNA repair inhibitor actually inhibits ICL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c66e2b21ec7efb37be08de1aebf0dc5
https://doi.org/10.1016/j.bmc.2015.09.045
https://doi.org/10.1016/j.bmc.2015.09.045