Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Benny C. Askew"'
Autor:
Randall W. Hungate, Ming Huang, Gloria Biddlecome, Jason Brooks Human, Benny C. Askew, Jian J. Chen, Dianna Lester-Zeiner, Eileen Johnson, Wenyuan Qian, Barton H. Manning, Leyla Arik, Richard Loeloff, Toshihiro Aya, Kaustav Biswas, Hong Dong, Tanya Peterkin, Hong Sun, Gondi N. Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4764-4769
We report the development of aryl sulfones as Bradykinin B1 receptor antagonists. Variation of the linker region identified diol 23 as a potent B1 antagonist, while modifications of the aryl moiety led to compound 26, both of which were efficacious i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c203023ad80d700642c9509253c1f5f
https://doi.org/10.1016/j.bmcl.2008.07.108
https://doi.org/10.1016/j.bmcl.2008.07.108
Autor:
Randall W. Hungate, Eileen Johnson, Kaustav Biswas, Leyla Arik, Benny C. Askew, Stephen Hitchcock, Vellarkad N. Viswanadhan, Wenyuan Qian, Jian J. Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4477-4481
Replacement of the core beta-amino acid in our previously reported piperidine acetic acid and beta-phenylalanine-based Bradykinin B1 antagonists by dihydroquinoxalinone acetic acid increases the in vitro potency and metabolic stability. The most pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592d6e20d725875d95801af2c32b7c12
https://doi.org/10.1016/j.bmcl.2008.07.055
https://doi.org/10.1016/j.bmcl.2008.07.055
Autor:
Burgess Laurence E, Leyla Arik, Chester Chenguang Yuan, Nianhe Han, Randall W. Hungate, Derin C. D'amico, David A. Mareska, Feng-Yin Hsieh, Eileen Johnson, Hong Sun, Qingyian Liu, Barton H. Manning, Bobby Riahi, Christopher H. Fotsch, Gloria Biddlecome, Mark H. Norman, Augustus Kamassah, Ming Huang, Richard Loeloff, Gondi N. Kumar, Andras Toro, Jian J. Chen, Jason Brooks Human, Hideo Suzuki, Robert D. Groneberg, Benny C. Askew, Aiwen Li, Gordon Ng, James Zhan, Kaustav Biswas, Dianna Lester-Zeiner, Hong Dong, David E. Clarke
Publikováno v:
Journal of Medicinal Chemistry. 50:2200-2212
The bradykinin B1 receptor is induced following tissue injury and/or inflammation. Antagonists of this receptor have been studied as promising candidates for treatment of chronic pain. We have identified aryl sulfonamides containing a chiral chroman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb42b5aad05a1dc5bda8d29f83bc6dc6
https://doi.org/10.1021/jm070055c
https://doi.org/10.1021/jm070055c
Autor:
Tanya Peterkin, Kaustav Biswas, Neil G. Andersen, Babak Riahi, Jian J. Chen, Gondi N. Kumar, Janan Jona, Kevin Yang, Judy Wang, Derin C. D'amico, Jason Brooks Human, Benny C. Askew, Thomas T. Nguyen, Qingyian Liu, Augustus Kamassah, Margaret M. Faul, Nobuko Nishimura, Christopher H. Fotsch, Wenyuan Qian, Eileen Johnson, Jiawang Zhu, Toshihiro Aya, Nianhe Han, Randall W. Hungate, John T. Colyer
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(11)
The discovery of novel and highly potent oxopiperazine based B1 receptor antagonists is described. Compared to the previously described arylsulfonylated (R)-3-amino-3-phenylpropionic acid series, the current compounds showed improved in vitro potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb9aeb3661b15590aeaea60c2a5a66d
https://pubmed.ncbi.nlm.nih.gov/21514825
https://pubmed.ncbi.nlm.nih.gov/21514825
Autor:
Benny C. Askew
Publikováno v:
ChemInform. 22
Macrobicyclic structures in which carboxylate derivatives converge on a central cavity have been prepared. This report details the synthesis of the first of a series of such hosts and discusses their ability to complex amino acids in aqueous solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95180bc9ac1577a57fd15ac6dce68627
https://doi.org/10.1002/chin.199133208
https://doi.org/10.1002/chin.199133208
Autor:
Benny C. Askew
Publikováno v:
Tetrahedron Letters. 31:4245-4248
Macrobicyclic structures in which carboxylate derivatives converge on a central cavity have been prepared. This report details the synthesis of the first of a series of such hosts and discusses their ability to complex amino acids in aqueous solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdf63aeeb13a15d1acde73029f2f4fd0
https://doi.org/10.1016/s0040-4039(00)97591-9
https://doi.org/10.1016/s0040-4039(00)97591-9
Autor:
David A. Mareska, Dianna Lester-Zeiner, Randall W. Hungate, Eileen Johnson, Toshi Aya, Leyla Arik, Bobby Riahi, Mark H. Norman, Augustus Kamassah, Jian J. Chen, Gloria Biddlecome, Judy Wang, Christopher H. Fotsch, Paul J. Reider, Jason Brooks Human, Benny C. Askew, Derin C. D'amico, Andras Toro, Burgess Laurence E, Carlo van Staden, Vellarkad N. Viswanadhan, Laird Ellen, Darren Martin Harvey, David E. Clarke, Gordon Ng, James Zhan, Kaustav Biswas, Christopher A. Willoughby, Hideo Suzuki, Robert D. Groneberg
Publikováno v:
Journal of medicinal chemistry. 50(4)
We report the discovery of chroman 28, a potent and selective antagonist of human, nonhuman primate, rat, and rabbit bradykinin B1 receptors (0.4-17 nM). At 90 mg/kg s.c., 28 decreased plasma extravasation in two rodent models of inflammation. A nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf3310fcb384164cb4574a4189d2825
https://pubmed.ncbi.nlm.nih.gov/17243660
https://pubmed.ncbi.nlm.nih.gov/17243660
A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core
Autor:
David A. Mareska, Eileen Johnson, Christopher H. Fotsch, Dianna Lester-Zeiner, Qingyian Liu, Gloria Biddlecome, Gordon Ng, James Zhan, Kaustav Biswas, Nianhe Bruce Han, Yueh-Ju Judy Wang, Joe Zhu, Babak Riahi, Gondi N. Kumar, Kevin Yang, Robert D. Groneberg, Derin C. D'amico, Feng-Yin Hsieh, Jian Jeff Chen, Benny C. Askew, Augustus Kamassah
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(8)
The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5310f114bdf0cdb04629d50164f8f659
https://pubmed.ncbi.nlm.nih.gov/16464576
https://pubmed.ncbi.nlm.nih.gov/16464576