Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Benno Rothenhäusler"'
Autor:
Marjolein Soethoudt, Uwe Grether, Jürgen Fingerle, Travis W. Grim, Filomena Fezza, Luciano de Petrocellis, Christoph Ullmer, Benno Rothenhäusler, Camille Perret, Noortje van Gils, David Finlay, Christa MacDonald, Andrea Chicca, Marianela Dalghi Gens, Jordyn Stuart, Henk de Vries, Nicolina Mastrangelo, Lizi Xia, Georgios Alachouzos, Marc P. Baggelaar, Andrea Martella, Elliot D. Mock, Hui Deng, Laura H. Heitman, Mark Connor, Vincenzo Di Marzo, Jürg Gertsch, Aron H. Lichtman, Mauro Maccarrone, Pal Pacher, Michelle Glass, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB2 receptor agonists and antagonists, recommending three that appear most suitab
Externí odkaz:
https://doaj.org/article/d8fb448abc4444e3a10089f8b36e11e6
Autor:
Richard Frederick Porter, Anna-Maria Szczesniak, James Thomas Toguri, Simon Gebremeskel, Brent Johnston, Christian Lehmann, Jürgen Fingerle, Benno Rothenhäusler, Camille Perret, Mark Rogers-Evans, Atsushi Kimbara, Matthias Nettekoven, Wolfgang Guba, Uwe Grether, Christoph Ullmer, Melanie E. M. Kelly
Publikováno v:
Molecules, Vol 24, Iss 18, p 3338 (2019)
(1) Background: The cannabinoid 2 receptor (CB2R) is a promising anti-inflammatory drug target and development of selective CB2R ligands may be useful for treating sight-threatening ocular inflammation. (2) Methods: This study examined the pharmacolo
Externí odkaz:
https://doaj.org/article/ef31d0daf6414bf7b58b32c719590b99
Autor:
Jürgen Thun, Benno Rothenhäusler, Alf Willmann, Stefanie Ulrike Schumacher, Martin Kuentz, Regina Moog
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 137:96-103
Hydrates are of great pharmaceutical relevance and even though they have been characterized thoroughly by various analytical techniques, there is barely literature available on molecular mobility of the hydrate water studied by NMR relaxation in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1c80d1f5bbcf55558269ef63ce061e
https://doi.org/10.1016/j.jpba.2017.01.017
https://doi.org/10.1016/j.jpba.2017.01.017
Autor:
Camille Perret, Mark Rogers-Evans, Simon Gebremeskel, Christoph Ullmer, James T. Toguri, Matthias Nettekoven, Atsushi Kimbara, Melanie E. M. Kelly, Christian Lehmann, Jürgen Fingerle, Benno Rothenhäusler, Uwe Grether, Anna-Maria Szczesniak, Richard F. Porter, Brent Johnston, Wolfgang Guba
Publikováno v:
Molecules
Molecules, Vol 24, Iss 18, p 3338 (2019)
Volume 24
Issue 18
Molecules, Vol 24, Iss 18, p 3338 (2019)
Volume 24
Issue 18
(1) Background: The cannabinoid 2 receptor (CB2R) is a promising anti-inflammatory drug target and development of selective CB2R ligands may be useful for treating sight-threatening ocular inflammation. (2) Methods: This study examined the pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63af72ac6c766fa1b248704aba70c451
https://pubmed.ncbi.nlm.nih.gov/31540271
https://pubmed.ncbi.nlm.nih.gov/31540271
NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS
Autor:
Thomas Wirth, Benno Rothenhäusler, Qian Li, Irene Knuesel, Uwe Grether, Matthias Nettekoven, Christine Schurr, Albert C. Ludolph, Christoph Ullmer, Bernd Baumann, Catarina Raposo, Najwa Ouali Alami, Giorgio Ottaviani, Linyun Tang, Alpaslan Tasdogan, Francesco Roselli, Jürgen Fingerle, Tobias M. Boeckers, Mark Rogers-Evans, Atsushi Kimbara, Stephan Röver, Florian olde Heuvel
Publikováno v:
The EMBO Journal
Astrocytes are involved in non-cell-autonomous pathogenic cascades in amyotrophic lateral sclerosis (ALS); however, their role is still debated. We show that astrocytic NF-κB activation drives microglial proliferation and leukocyte infiltration in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658c33bb6b1974e26d688f66320f65f9
http://europepmc.org/articles/PMC6092622
http://europepmc.org/articles/PMC6092622
Autor:
Sebastien Schmitt, Giorgio Ottaviani, Bernd Püllmann, Catarina Bissantz, Atsushi Kimbara, Sabine Grüner, Jean-Michel Adam, Benno Rothenhäusler, Matthias Nettekoven, Jürgen Fingerle, Wolfgang Guba, Franz Schuler, Tanja Schulz-Gasch, Stephan Röver, Stefanie Bendels, Mark Rogers-Evans, Christoph Ullmer, Uwe Grether
Publikováno v:
ChemMedChem. 11:179-189
The cannabinoid receptor 2 (CB2) system is described to modulate various pathological conditions, including inflammation and fibrosis. A series of new heterocyclic small-molecule CB2 receptor agonists were identified from a high-throughput screen. Le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d5076f262721e5c520fa894595a624
https://doi.org/10.1002/cmdc.201500218
https://doi.org/10.1002/cmdc.201500218
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 115
Wet media milling is a well-established unit operation for the manufacturing of suspension formulations during early phase pharmaceutical development. However, knowledge about the kinetics of particle breakage is limited, although the impact of hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b91971dfe60869d4ecbdc9a5f1f7eb
https://pubmed.ncbi.nlm.nih.gov/29278757
https://pubmed.ncbi.nlm.nih.gov/29278757
Autor:
Jordyn Stuart, Hui Deng, Vincenzo Di Marzo, Marjolein Soethoudt, Andrea Chicca, Jürg Gertsch, Mark Connor, Uwe Grether, Lizi Xia, Christa MacDonald, Elliot D. Mock, Georgios Alachouzos, Pal Pacher, Camille Perret, Henk de Vries, Benno Rothenhäusler, Travis W. Grim, Christoph Ullmer, Juergen Fingerle, Filomena Fezza, Michelle Glass, Mauro Maccarrone, Mario van der Stelt, Marc P. Baggelaar, David B. Finlay, Luciano De Petrocellis, Marianela Dalghi Gens, Laura H. Heitman, Andrea Martella, Aron H. Lichtman, Noortje van Gils, Nicolina Mastrangelo
Publikováno v:
Nature Communications, 8, 13958
Nature communications 8 (2017). doi:10.1038/ncomms13958
info:cnr-pdr/source/autori:Soethoudt, Marjolein; Grether, Uwe; Fingerle, Juergen; Grim, Travis W.; Fezza, Filomena; de Petrocellis, Luciano; Ullmer, Christoph; Rothenhausler, Benno; Perret, Camille; van Gils, Noortje; Finlay, David; MacDonald, Christa; Chicca, Andrea; Gens, Marianela Dalghi; Stuart, Jordyn; de Vries, Henk; Mastrangelo, Nicolina; Xia, Lizi; Alachouzos, Georgios; Baggelaar, Marc P.; Martella, Andrea; Mock, Elliot D.; Deng, Hui; Heitman, Laura H.; Connor, Mark; Di Marzo, Vincenzo; Gertsch, Jurg; Lichtman, Aron H.; Maccarrone, Mauro; Pacher, Pal; Glass, Michelle; van der Stelt, Mario/titolo:Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity/doi:10.1038%2Fncomms13958/rivista:Nature communications/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:8
Nature Communications
Soethoudt, Marjolein; Grether, Uwe; Fingerle, Jürgen; Grim, Travis W; Fezza, Filomena; de Petrocellis, Luciano; Ullmer, Christoph; Rothenhäusler, Benno; Perret, Camille; van Gils, Noortje; Finlay, David; MacDonald, Christa; Chicca, Andrea; Gens, Marianela Dalghi; Stuart, Jordyn; de Vries, Henk; Mastrangelo, Nicolina; Xia, Lizi; Alachouzos, Georgios; Baggelaar, Marc P; ... (2017). Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity. Nature communications, 8(13958), p. 13958. Nature Publishing Group 10.1038/ncomms13958
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature communications 8 (2017). doi:10.1038/ncomms13958
info:cnr-pdr/source/autori:Soethoudt, Marjolein; Grether, Uwe; Fingerle, Juergen; Grim, Travis W.; Fezza, Filomena; de Petrocellis, Luciano; Ullmer, Christoph; Rothenhausler, Benno; Perret, Camille; van Gils, Noortje; Finlay, David; MacDonald, Christa; Chicca, Andrea; Gens, Marianela Dalghi; Stuart, Jordyn; de Vries, Henk; Mastrangelo, Nicolina; Xia, Lizi; Alachouzos, Georgios; Baggelaar, Marc P.; Martella, Andrea; Mock, Elliot D.; Deng, Hui; Heitman, Laura H.; Connor, Mark; Di Marzo, Vincenzo; Gertsch, Jurg; Lichtman, Aron H.; Maccarrone, Mauro; Pacher, Pal; Glass, Michelle; van der Stelt, Mario/titolo:Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity/doi:10.1038%2Fncomms13958/rivista:Nature communications/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:8
Nature Communications
Soethoudt, Marjolein; Grether, Uwe; Fingerle, Jürgen; Grim, Travis W; Fezza, Filomena; de Petrocellis, Luciano; Ullmer, Christoph; Rothenhäusler, Benno; Perret, Camille; van Gils, Noortje; Finlay, David; MacDonald, Christa; Chicca, Andrea; Gens, Marianela Dalghi; Stuart, Jordyn; de Vries, Henk; Mastrangelo, Nicolina; Xia, Lizi; Alachouzos, Georgios; Baggelaar, Marc P; ... (2017). Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity. Nature communications, 8(13958), p. 13958. Nature Publishing Group 10.1038/ncomms13958
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75f8afe19194035304c041481432e51
https://hdl.handle.net/1887/48099
https://hdl.handle.net/1887/48099
Autor:
Benno Rothenhäusler, Sabine Grüner, Giorgio Ottaviani, Jean-Michel Adam, Tanja Schulz-Gasch, Matthias Nettekoven, Jürgen Fingerle, Mark Rogers-Evans, Sebastien Schmitt, Stefanie Bendels, Atsushi Kimbara, Wolfgang Guba, Franz Schuler, Stephan Röver, Bernd Püllmann, Catarina Bissantz, Uwe Grether, Christoph Ullmer
Publikováno v:
ChemMedChem. 11:147-147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f8183326c532dbec6dc2205d299847
https://doi.org/10.1002/cmdc.201500604
https://doi.org/10.1002/cmdc.201500604
Autor:
Benno Rothenhäusler, Wolfgang Knoll
Publikováno v:
Surface Science. 191:585-594
Attenuated total reflection measurements in the Kretschmann configuration are performed with various laser wavelengths at Ag surfaces with thin heterogeneous coatings. The plasmon surface polariton (PSP) resonances observed for samples that consist o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b45d60520a3e0cb485bf6a45ae203c
https://doi.org/10.1016/s0039-6028(87)81199-8
https://doi.org/10.1016/s0039-6028(87)81199-8