Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Bennett T. Farmer"'
Autor:
E. Michael August, Lana Louise Smith Keenan, Jun Li, S. Mariana Margarit, Alexander Heim-Riether, Hans-Dieter Junker, Kathleen Haverty, Neil A. Farrow, Brandon Collins, Bennett T. Farmer, Thomas Neumann, Shuang Liang, John R. Proudfoot, Renate Sekul, Qiang Zhang, Donghong Amy Gao, Steven John Taylor, Zhaoming Xiong, Neil Moss, Melissa Hill-Drzewi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5321-5324
Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was observed to have a binding mode distinct from previously published
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91cc7f3c887b95e837900c788a1ecfd
https://doi.org/10.1016/j.bmcl.2009.07.151
https://doi.org/10.1016/j.bmcl.2009.07.151
Autor:
Eugene R. Hickey, Anthony S. Prokopowicz, George E. Lee, Carol Ann Homon, Scott Jakes, Wang Mao, Jun Li, Charlene Peng, Bennett T. Farmer, Scott F. Leonard, Mohammed A. Kashem, Kevin Chungeng Qian, Charles L. Cywin, Lian Wang, Ronald Magboo, Morgan Welzel, John P. Wolak, Edward Pack, Tina Morwick
Publikováno v:
Journal of Medicinal Chemistry. 52:1814-1827
A series of inhibitors of Pim-2 kinase identified by high-throughput screening is described. Details of the hit validation and lead generation process and structure-activity relationship (SAR) studies are presented. Disclosure of an unconventional bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bdff6788836da6a99ef9f5bd96cab0
https://doi.org/10.1021/jm801242y
https://doi.org/10.1021/jm801242y
Autor:
Dianlin Xie, Ning Yan, Matthew D. Healy, Keith L. Constantine, Joseph Yanchunas, Brian A. Dougherty, Li Tao, Jane A. Thanassi, Bennett T. Farmer, Stanley R. Krystek, Michael L. Doyle, Valentina Goldfarb, Nathan O. Siemers
Publikováno v:
Protein Science. 14:1472-1484
CFE88 is a conserved essential gene product from Streptococcus pneumoniae. This 227-residue protein has minimal sequence similarity to proteins of known 3D structure. Sequence alignment models and computational protein threading studies suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72153de7f2505980e54beb8507d4e5c2
https://doi.org/10.1110/ps.051389605
https://doi.org/10.1110/ps.051389605
Fragment based drug discovery (FBDD) has played an important role in the past decade, helping in many cases to streamline the complex process of drug discovery from target validation to new drug application. A total of eighteen drug candidates discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61dccfa48f73ff06c107514dbe2ba2c5
https://doi.org/10.1016/b978-0-12-417205-0.00007-9
https://doi.org/10.1016/b978-0-12-417205-0.00007-9
Autor:
Anne Badel, Patrick Bazzini, Frans M. Belpaire, Alexandre Borrel, Koen Boussery, Christopher Brice, Anne-Claude Camproux, David Cavalla, Paola Ciapetti, Hongming Chen, Yong Mi Choi-Sledeski, Bernd Clement, Gordon M. Cragg, Patrick M. Dansette, Pierre deMontigny, Ji-Cui Dong, Iain G. Dougall, Ola Engkvist, Bernard Faller, Bennett T. Farmer, Delphine Flatters, Bruno Galli, Colette Geneix, Bruno Giethlen, Serge Grisoni, Gerhard Gross, David Harris, Yuichi Hashimoto, Chris Ho, Andrew L. Hopkins, Hiba Abi Hussein, Peter Imming, Minoru Ishikawa, Tim Jonckers, Sabine Kopp, David G.I. Kingston, Thierry Kogej, Sophie Lasseur, Dominique Lesuisse, Harvey Lieberman, Richard Luthi, Anne-Christine Macherey, André Mann, Raffaella G. Balocco Mattavelli, Christophe Morice, Richard Morphy, David J. Newman, Anne Olivier, Michel Petitjean, Pierre Raboisson, Zoran Rankovic, Leslie Regad, Allen B. Reitz, Bernd U. Riebesehl, Jean-Philippe Rocher, Tiago Rodrigues, A. Romeo, Jean-Michel Rondeau, Laurent Schaeffer, Jean-Michel Scherrmann, Gisbert Schneider, Herman Schreuder, Wolfgang Sippl, Erin M. Skoda, Olivier Taboureau, Bernard Testa, John Unitt, Johan Van de Voorde, Walter M.M. Van den Broeck, N. Murti Vemuri, Venkata Velvadapu, Franz Weiberth, Bruno Villoutreix, Camille G. Wermuth, Peter Wipf, Gerhard Wolber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ac78ac235601f775503cbb8ecc81d18
https://doi.org/10.1016/b978-0-12-417205-0.00044-4
https://doi.org/10.1016/b978-0-12-417205-0.00044-4
Autor:
William J. Metzler, Keith L. Constantine, Stephen R. Johnson, Patricia A. McDonnell, Thomas J. Caulfield, David R. Magnin, Richard B. Sulsky, Jeffrey A. Robl, Luciano Mueller, Valentina Goldfarb, David S. Taylor, Bennett T. Farmer, Rex A. Parker, Leonard P. Adam
Publikováno v:
Journal of Medicinal Chemistry. 49:5013-5017
The NMR structure is presented for compound 1 (BMS-480404) (Ki = 33 (+/-2) nM) bound to keratinocyte fatty acid-binding protein. This article describes interactions between a high affinity drug-like compound and a member of the fatty acid-binding pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039f11b8a4e507d4665321b39727f91d
https://doi.org/10.1021/jm060360i
https://doi.org/10.1021/jm060360i
Autor:
and Luciano Mueller, Rex A. Parker, Michael Wittekind, Mark S. Friedrichs, Ching-Hsuen Chu, Keith L. Constantine, Ii‡ Bennett T. Farmer, Valentina Goldfarb, Jamil Haris
Publikováno v:
Biochemistry. 37:7965-7980
Adipocyte lipid-binding protein (A-LBP) and muscle fatty acid-binding protein (M-FABP) are members of a family of small ( approximately 15 kDa) cytosolic proteins that are involved in the metabolism of fatty acids and other lipid-soluble molecules. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b4b6f70f6468e9307bbd02944826ef
https://doi.org/10.1021/bi980203o
https://doi.org/10.1021/bi980203o
Publikováno v:
Journal of the American Chemical Society. 118:3253-3261
Anomalous crosspeaks and additional resonances in the indirectly detected dimension have been previously observed in a number of 2D NMR experiments applied to samples having at least one concentrated species. These unexpected peaks exhibit all the ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1cb76d8da9a9b4fe105ece1ece73c98
https://doi.org/10.1021/ja953186o
https://doi.org/10.1021/ja953186o
Autor:
Chih Chin Huang, Carol A. Fierke, Ronald A. Venters, Leonard D. Spicer, Ronald Trolard, Bennett T. Farmer
Publikováno v:
Journal of Biomolecular NMR. 5:339-344
The protein human carbonic anhydrase II (HCA II) has been isotopically labeled with 2H, 13C and 15N for high-resolution NMR assignment studies and pulse sequence development. To increase the sensitivity of several key 1H/13C/15N triple-resonance corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0a9e109dfa96b4cde49f033095de0f
https://doi.org/10.1007/bf00182275
https://doi.org/10.1007/bf00182275
Publikováno v:
Journal of Magnetic Resonance, Series B. 107:197-200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a35f34a67cac17d2c64a4a344d1ef1e
https://doi.org/10.1006/jmrb.1995.1079
https://doi.org/10.1006/jmrb.1995.1079