Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bennett G. Childs"'
Autor:
Camille Cohen, Océane Le Goff, Frédéric Soysouvanh, Florence Vasseur, Marine Tanou, Clément Nguyen, Lucile Amrouche, Julien Le Guen, Oriana Saltel‐Fulero, Tanguy Meunier, Thao Nguyen‐Khoa, Marion Rabant, Dominique Nochy, Christophe Legendre, Gérard Friedlander, Bennett G Childs, Daren J Baker, Bertrand Knebelmann, Dany Anglicheau, Fabien Milliat, Fabiola Terzi
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)
Abstract The mechanisms underlying the development of glomerular lesions during aging are largely unknown. It has been suggested that senescence might play a role, but the pathophysiological link between senescence and lesion development remains unex
Externí odkaz:
https://doaj.org/article/eff346c772ac4a2782e8d2599fcc5044
Publikováno v:
Nature Cell Biology.
Autor:
Cheng Zhang, Bennett G. Childs, Hu Li, Raul O. Fierro Velasco, Ines Sturmlechner, Fahad Shuja, Darren J. Baker, Jan M. van Deursen, Shawn Trewartha
Publikováno v:
Nat Aging
Senescent cells (SNCs) degenerate the fibrous cap that normally prevents atherogenic plaque rupture, a leading cause of myocardial infarction and stroke. Here we explore the underlying mechanism using pharmacological or transgenic approaches to clear
Autor:
Alireza Khodadadi-Jamayran, Stephen C. Textor, Timothy B. Niewold, Xiangyang Zhu, Ian Taylor, Amir Lerman, Tamara Tchkonia, Lilach O. Lerman, Xiao Jun Chen, James L. Kirkland, Amrutesh S. Puranik, Seo Rin Kim, La Tonya J. Hickson, Bennett G. Childs, Kai Jiang
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Peripheral vascular diseases may induce chronic ischemia and cellular injury distal to the arterial obstruction. Cellular senescence involves proliferation arrest in response to stress, which can damage neighboring cells. Renal artery ste
Autor:
Brian A. Davies, Johanna A. Payne, Cole P. Martin, Destiny Schultz, Bennett G. Childs, Cheng Zhang, Karthik Jeganathan, Ines Sturmlechner, Thomas A. White, Alain de Bruin, Huiqin Chen, Michael A. Davies, Sarah Jachim, Nathan K. LeBrasseur, Robert C. Piper, Hu Li, Darren J. Baker, Jan van Deursen, David J. Katzmann
Endosomal Sorting Complexes Required for Transport (ESCRTs) drive reverse topology membrane remodeling events including the formation of intralumenal vesicles within multivesicular bodies, the budding of retroviruses from the plasma membrane, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb5c3cb386817736dfe03b4a5f056e3
https://doi.org/10.1101/2022.08.02.502401
https://doi.org/10.1101/2022.08.02.502401
Autor:
Guilherme C. de Oliveira, Tamara Tchkonia, Karthikeyani Chellappa, Karina S. Kanamori, Connor Jankowski, Katie L. Thompson, Guillermo Agorrody, Joshua D. Rabinowitz, Amrutesh S. Puranik, James L. Kirkland, Jan M. van Deursen, Kevin Dang, Gina M. Warner, Claudia C.S. Chini, Micaela A. Witte, Eduardo N. Chini, Lilian S Gomez, Starlynn Clarke, Thais Peclat, Jair Machado Espindola-Netto, Melanie R. McReynolds, Kelly A. Hogan, Marco De Cecco, Wim Van Schooten, Darren J. Baker, Paola Vidal, Bennett G. Childs, Sonu Kashyap, Mariana G. Tarragó, Joseph A. Baur, Anna L. Kirkland, John M. Sedivy
Publikováno v:
Nature metabolism
Decreased nicotinamide adenine dinucleotide (NAD+) levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated duri
Autor:
Florence Vasseur, Fabien Milliat, Dominique Nochy, Daren J Baker, Marine Tanou, Christophe Legendre, Camille Cohen, Clément Nguyen, Bennett G. Childs, Tanguy Meunier, Julien Le Guen, Frédéric Soysouvanh, Fabiola Terzi, Bertrand Knebelmann, Gérard Friedlander, Océane Le Goff, Thao Nguyen-Khoa, Marion Rabant, Oriana Saltel-Fulero, Lucile Amrouche, Dany Anglicheau
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine
The mechanisms underlying the development of glomerular lesions during aging are largely unknown. It has been suggested that senescence might play a role, but the pathophysiological link between senescence and lesion development remains unexplained.
Autor:
Jan M. van Deursen, Bennett G. Childs
Publikováno v:
Nature
DNA sequences called retrotransposons can copy themselves and reintegrate at new sites in the genome, causing damage. It now seems that inhibiting this process can prevent age-related health decline in mice. A role for the retrotransposon LINE-1 in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c863c223c608cf27a79c25c77feb1979
https://europepmc.org/articles/PMC9555246/
https://europepmc.org/articles/PMC9555246/
Cellular Identification and Quantification of Senescence-Associated β-Galactosidase Activity In Vivo
Publikováno v:
Methods in Molecular Biology ISBN: 9781493989300
Senescence-associated β-galactosidase (hereafter SA-β-gal) staining has now been employed for more than 20 years to identify the presence of senescent cells (Dimri et al., Proc Natl Acad Sci U S A 92:9363-9367, 1995). These cells, characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609c1c063e9b60a9cfb221b6c2e5ef6c
https://doi.org/10.1007/978-1-4939-8931-7_4
https://doi.org/10.1007/978-1-4939-8931-7_4
Publikováno v:
Journal of Clinical Investigation, 128, 4, pp. 1217-1228
Journal of Clinical Investigation, 128, 1217-1228
Journal of Clinical Investigation, 128, 1217-1228
Contains fulltext : 196267.pdf (Publisher’s version ) (Open Access) Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a863eac7220ee37fed0433f36fd455
https://hdl.handle.net/2066/196267
https://hdl.handle.net/2066/196267