Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Bennett G. Childs"'
Autor:
Camille Cohen, Océane Le Goff, Frédéric Soysouvanh, Florence Vasseur, Marine Tanou, Clément Nguyen, Lucile Amrouche, Julien Le Guen, Oriana Saltel‐Fulero, Tanguy Meunier, Thao Nguyen‐Khoa, Marion Rabant, Dominique Nochy, Christophe Legendre, Gérard Friedlander, Bennett G Childs, Daren J Baker, Bertrand Knebelmann, Dany Anglicheau, Fabien Milliat, Fabiola Terzi
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-20 (2021)
Abstract The mechanisms underlying the development of glomerular lesions during aging are largely unknown. It has been suggested that senescence might play a role, but the pathophysiological link between senescence and lesion development remains unex
Externí odkaz:
https://doaj.org/article/eff346c772ac4a2782e8d2599fcc5044
Publikováno v:
Nature Cell Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b799a7bdcabab0813621811bf94d6f26
https://doi.org/10.1038/s41556-023-01153-5
https://doi.org/10.1038/s41556-023-01153-5
Autor:
Cheng Zhang, Bennett G. Childs, Hu Li, Raul O. Fierro Velasco, Ines Sturmlechner, Fahad Shuja, Darren J. Baker, Jan M. van Deursen, Shawn Trewartha
Publikováno v:
Nat Aging
Senescent cells (SNCs) degenerate the fibrous cap that normally prevents atherogenic plaque rupture, a leading cause of myocardial infarction and stroke. Here we explore the underlying mechanism using pharmacological or transgenic approaches to clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0d8ad257fc57dd562ce2ab4f4a87be
https://doi.org/10.1038/s43587-021-00089-5
https://doi.org/10.1038/s43587-021-00089-5
Autor:
Brian A. Davies, Johanna A. Payne, Cole P. Martin, Destiny Schultz, Bennett G. Childs, Cheng Zhang, Karthik Jeganathan, Ines Sturmlechner, Thomas A. White, Alain de Bruin, Huiqin Chen, Michael A. Davies, Sarah Jachim, Nathan K. LeBrasseur, Robert C. Piper, Hu Li, Darren J. Baker, Jan van Deursen, David J. Katzmann
Endosomal Sorting Complexes Required for Transport (ESCRTs) drive reverse topology membrane remodeling events including the formation of intralumenal vesicles within multivesicular bodies, the budding of retroviruses from the plasma membrane, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb5c3cb386817736dfe03b4a5f056e3
https://doi.org/10.1101/2022.08.02.502401
https://doi.org/10.1101/2022.08.02.502401
Autor:
Guilherme C. de Oliveira, Tamara Tchkonia, Karthikeyani Chellappa, Karina S. Kanamori, Connor Jankowski, Katie L. Thompson, Guillermo Agorrody, Joshua D. Rabinowitz, Amrutesh S. Puranik, James L. Kirkland, Jan M. van Deursen, Kevin Dang, Gina M. Warner, Claudia C.S. Chini, Micaela A. Witte, Eduardo N. Chini, Lilian S Gomez, Starlynn Clarke, Thais Peclat, Jair Machado Espindola-Netto, Melanie R. McReynolds, Kelly A. Hogan, Marco De Cecco, Wim Van Schooten, Darren J. Baker, Paola Vidal, Bennett G. Childs, Sonu Kashyap, Mariana G. Tarragó, Joseph A. Baur, Anna L. Kirkland, John M. Sedivy
Publikováno v:
Nature metabolism
Decreased nicotinamide adenine dinucleotide (NAD+) levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f293082b523d28c2c49e835f21eb18
http://europepmc.org/articles/PMC8752031
http://europepmc.org/articles/PMC8752031
Cellular Identification and Quantification of Senescence-Associated β-Galactosidase Activity In Vivo
Publikováno v:
Methods in Molecular Biology ISBN: 9781493989300
Senescence-associated β-galactosidase (hereafter SA-β-gal) staining has now been employed for more than 20 years to identify the presence of senescent cells (Dimri et al., Proc Natl Acad Sci U S A 92:9363-9367, 1995). These cells, characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609c1c063e9b60a9cfb221b6c2e5ef6c
https://doi.org/10.1007/978-1-4939-8931-7_4
https://doi.org/10.1007/978-1-4939-8931-7_4
Publikováno v:
Journal of Clinical Investigation, 128, 4, pp. 1217-1228
Journal of Clinical Investigation, 128, 1217-1228
Journal of Clinical Investigation, 128, 1217-1228
Contains fulltext : 196267.pdf (Publisher’s version ) (Open Access) Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a863eac7220ee37fed0433f36fd455
https://hdl.handle.net/2066/196267
https://hdl.handle.net/2066/196267
Publikováno v:
Current Stem Cell Reports. 1:151-161
Organismal aging is characterized by a progressive loss of tissue homeostasis and impaired function over time. Multi-cellular organisms activate stem and progenitor cells to replace damaged cells in order to continuously meet the functional demands o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f837b7fe6c6e4f69f059d4b6e8954ef6
https://doi.org/10.1007/s40778-015-0020-6
https://doi.org/10.1007/s40778-015-0020-6
Publikováno v:
Nature Medicine, 21, 1424-35
Nature Medicine, 21, 12, pp. 1424-35
Nature Medicine, 21, 12, pp. 1424-35
Contains fulltext : 152005.pdf (Publisher’s version ) (Closed access) Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to various stressors, has emerged as a potentially important contributor to aging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02988163e8f016afa57b33f41ec39c7b
https://hdl.handle.net/2066/152005
https://hdl.handle.net/2066/152005
Autor:
Martina Gluscevic, Jamie Dananberg, Dan Marquess, Bennett G. Childs, Remi-Martin Laberge, Jan M. van Deursen, Darren J. Baker
Publikováno v:
Nature Reviews. Drug Discovery, 16, 718-735
Nature Reviews. Drug Discovery, 16, 10, pp. 718-735
Nature Reviews. Drug Discovery, 16, 10, pp. 718-735
Contains fulltext : 182660.pdf (Publisher’s version ) (Closed access) Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e66da9a53d6aae38e8f223c031a7d7b
https://doi.org/10.1038/nrd.2017.116
https://doi.org/10.1038/nrd.2017.116