Zobrazeno 1 - 10
of 10 915
pro vyhledávání: '"Bennett D."'
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract A critical aspect of cancer vaccine development is the formulation with effective adjuvants. This study evaluated whether combining a cationic plant-derived nanoparticle adjuvant (Nano-11) with the clinically tested STING agonist ADU-S100 (M
Externí odkaz:
https://doaj.org/article/cfb9c57673864443b24aa9835069823c
Autor:
Zhili Li, Woojun Kim, Sagar Utturkar, Bingyu Yan, Nadia Atallah Lanman, Bennett D. Elzey, Majid Kazemian, Yoon Yeo, Ourania Andrisani
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-14 (2024)
Abstract In advanced hepatocellular carcinoma (HCC), RNA helicase DDX5 regulates the Wnt/β-catenin-ferroptosis axis, influencing the efficacy of the multi-tyrosine kinase inhibitor (mTKI) sorafenib. DDX5 inhibits Wnt/β-catenin signaling, preventing
Externí odkaz:
https://doaj.org/article/30314fb41df041168377fa1afba66aba
Autor:
Kyle B. Lupo, Xue Yao, Shambhavi Borde, Jiao Wang, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, MacKenzie McIntosh, Sandro Matosevic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Severe heterogeneity within glioblastoma has spurred the notion that disrupting the interplay between multiple elements on immunosuppression is at the core of meaningful anti-tumor responses. T cell immunoreceptor with Ig and ITIM domains (T
Externí odkaz:
https://doaj.org/article/1e2e1119049944b2a09484ad5864089e
Autor:
Zhili Li, Claude Caron de Fromentel, Woojun Kim, Wen-Hung Wang, Jiazeng Sun, Bingyu Yan, Sagar Utturkar, Nadia Atallah Lanman, Bennett D. Elzey, Yoon Yeo, Hao Zhang, Majid Kazemian, Massimo Levrero, Ourania Andrisani
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-14 (2023)
Abstract Reduced expression of the RNA helicase DDX5 associated with increased hepatocellular carcinoma (HCC) tumor grade and poor patient survival following treatment with sorafenib. While immunotherapy is the first-line treatment for HCC, sorafenib
Externí odkaz:
https://doaj.org/article/3768119de0414d8a98fbd38fbf6f6e99
Autor:
Yun Chang, Gyuhyung Jin, Weichuan Luo, Qian Luo, Juhyung Jung, Sydney N. Hummel, Sandra Torregrosa-Allen, Bennett D. Elzey, Philip S. Low, Xiaojun Lance Lian, Xiaoping Bao
Publikováno v:
Bioactive Materials, Vol 27, Iss , Pp 168-180 (2023)
Adoptive chimeric antigen receptor (CAR)-engineered natural killer (NK) cells have shown promise in treating various cancers. However, limited immunological memory and access to sufficient numbers of allogenic donor cells have hindered their broader
Externí odkaz:
https://doaj.org/article/132da242ecf24ecdaf6268b9a29f76ac
Autor:
Young Joo Lee, Lihua Chen, Janhavi Nistane, Hye Youn Jang, Dylan J. Weber, Joseph K. Scott, Neel D. Rangnekar, Bennett D. Marshall, Wenjun Li, J. R. Johnson, Nicholas C. Bruno, M. G. Finn, Rampi Ramprasad, Ryan P. Lively
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Membrane-based organic solvent separations are rapidly emerging as a promising class of technologies for enhancing the energy efficiency of existing separation and purification systems. Polymeric membranes have shown promise in the fractiona
Externí odkaz:
https://doaj.org/article/babb256d06bd41cf8c0d517a183e3f76
TIGIT contributes to the regulation of 4-1BB and does not define NK cell dysfunction in glioblastoma
Autor:
Kyle B. Lupo, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, Aaron A. Cohen-Gadol, Veronika Slivova, MacKenzie McIntosh, Karen E. Pollok, Sandro Matosevic
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108353- (2023)
Summary: TIGIT is a receptor on human natural killer (NK) cells. Here, we report that TIGIT does not spontaneously induce inhibition of NK cells in glioblastoma (GBM), but rather acts as a decoy-like receptor, by usurping binding partners and regulat
Externí odkaz:
https://doaj.org/article/fc412162de6f40f686eec4555f885cb5
Autor:
Yun Chang, Xuechao Cai, Ramizah Syahirah, Yuxing Yao, Yang Xu, Gyuhyung Jin, Vijesh J. Bhute, Sandra Torregrosa-Allen, Bennett D. Elzey, You-Yeon Won, Qing Deng, Xiaojun Lance Lian, Xiaoguang Wang, Omolola Eniola-Adefeso, Xiaoping Bao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and chemotherapeutics, have been developed to treat various cancers,
Externí odkaz:
https://doaj.org/article/6d014b190d954c29a0b1699c22696334
Autor:
Cih Cheng, Naomi Deneke, Hye-ran Moon, Sae Rome Choi, Natalia Ospina-Muñoz, Bennett D. Elzey, Chelsea S. Davis, George T.-C Chiu, Bumsoo Han
Publikováno v:
Materials Today Advances, Vol 19, Iss , Pp 100408- (2023)
Recent advances in biomaterials and 3D printing/culture methods enable various tissue-engineered tumor models. However, it is still challenging to achieve native tumor-like characteristics due to lower cell density than native tissues and prolonged c
Externí odkaz:
https://doaj.org/article/fea26d9d66d24ee0b396dfe569eef5c5
Autor:
Cayla Boycott, Megan Beetch, Tony Yang, Katarzyna Lubecka, Yuexi Ma, Jiaxi Zhang, Lucinda Kurzava Kendall, Melissa Ullmer, Benjamin S. Ramsey, Sandra Torregrosa-Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Alisa Hui, Nathaniel Villanueva, Aline de Conti, Tao Huan, Igor Pogribny, Barbara Stefanska
Publikováno v:
Epigenetics, Vol 17, Iss 11, Pp 1513-1534 (2022)
Hepatocellular carcinoma (HCC) is mostly triggered by environmental and life-style factors and may involve epigenetic aberrations. However, a comprehensive documentation of the link between the dysregulated epigenome, transcriptome, and liver carcino
Externí odkaz:
https://doaj.org/article/3794d341f23d46428a14e67c237ba7c6