Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bennett C. Laguzza"'
Autor:
S L Briggs, Hinson Na, Corvalan, C L Nichols, James J. Starling, Smith W, Maciak Rs, Bennett C. Laguzza
Publikováno v:
Bioconjugate Chemistry. 3:315-322
A panel of four murine monoclonal antibodies apparently directed against three distinct epitopes of carcinoembryonic antigen (CEA) was conjugated via oxidized carbohydrate groups to 4-desacetylvinblastine-3-carboxyhydrazide. The resulting antibody-vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7379f2a0193924815dc44abd9c767c28
https://doi.org/10.1021/bc00016a010
https://doi.org/10.1021/bc00016a010
Publikováno v:
Tetrahedron Letters. 22:3339-3342
A synthesis of 5 S ,12 S -di-HETE ( 2 ) is reported which confirms the proposed structure and stereochemistry for this biologically active, natural eicosanoid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42a8e3f0bf5f7f0f55eab573e4f9d13d
https://doi.org/10.1016/s0040-4039(01)81899-2
https://doi.org/10.1016/s0040-4039(01)81899-2
Publikováno v:
Tetrahedron Letters. 24:4913-4916
The two isomeric hydroxy-11,12-epoxides produced from arachidonic acid in mammalian blood platelets have been identified by comparison with totally synthetic substances as the C(10)-diastereomers of 2 .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb76639edab5761b158b427322fb3fe
https://doi.org/10.1016/s0040-4039(01)99809-0
https://doi.org/10.1016/s0040-4039(01)99809-0
Autor:
Bruce Ganem, Bennett C. Laguzza
Publikováno v:
Tetrahedron Letters. 22:1483-1486
An acid and base-stable, nucleophile-resistant protecting group for primary amines and α-amino acids is described which has been used in a synthesis of the title compound.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526a0b3342978f7bccfaf6463ead7ac6
https://doi.org/10.1016/s0040-4039(01)90356-9
https://doi.org/10.1016/s0040-4039(01)90356-9
Autor:
George Joseph Cullinan, Bennett C. Laguzza, J. R. F. Corvalan, T. F. Bumol, C L Nichols, James J. Starling, Stephen L. Briggs, David W. Johnson, A. L. Baker
Publikováno v:
Journal of medicinal chemistry. 32(3)
A method has been developed to allow the direct coupling of the cytotoxic vinca alkaloid 4-desacetylvinblastine-3-carbohydrazide (DAVLB hydrazide) to a variety of murine monoclonal antibodies directed against human solid tumors. Periodate oxidation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07043334e4247f79de9a939bae05d14f
https://pubmed.ncbi.nlm.nih.gov/2783975
https://pubmed.ncbi.nlm.nih.gov/2783975
Publikováno v:
Cancer Immunology Immunotherapy. 28
A panel of three hybridomas has been isolated each of which secretes a single species of monoclonal antibody (MoAb) directed against the KS1/4 tumor-associated antigen originally described by Varki et al. (Cancer Res 44: 681, 1984). These MoAbs were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9af64f639c87df0d3aefbc56b6e4cb
https://doi.org/10.1007/bf00204985
https://doi.org/10.1007/bf00204985
Publikováno v:
Journal of Ethnopharmacology. 22:316-317
The human squamous carcinoma-reactive murine monoclonal antibody PF1/D was used to derive a conjugate with the Vinca derivative 4-desacetylvinblastine-3-carboxyhydrazide (PF1/D-DAVLBHYD). This immunoconjugate was shown to be largely aggregate free an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::056fb56897d3e9d152a6e298530ba0b6
https://doi.org/10.1016/0378-8741(88)90249-8
https://doi.org/10.1016/0378-8741(88)90249-8