Zobrazeno 1 - 10
of 444
pro vyhledávání: '"Bennett, Ma"'
Autor:
Mark E. Layton, Jeffrey C. Kern, Timothy J. Hartingh, William D. Shipe, Izzat Raheem, Monika Kandebo, Robert P. Hayes, Sarah Huszar, Donnie Eddins, Bennett Ma, Joy Fuerst, Gordon K. Wollenberg, Jing Li, Jeff Fritzen, Georgia B. McGaughey, Jason M. Uslaner, Sean M. Smith, Paul J. Coleman, Christopher D. Cox
Publikováno v:
Journal of Medicinal Chemistry. 66:1157-1171
Autor:
Bennett Ma, Gregg Wesolowski, Bin Luo, Traci Lifsted, Keith Wessner, Gary Adamson, Helmut Glantschnig, Laura S Lubbers
Publikováno v:
Journal of Circulating Biomarkers, Vol 8 (2019)
Cathepsin K (CatK) inhibitors exhibited chondroprotective and pain-reducing effects in animal models, however, improvements were relatively modest at dose levels achieving maximal suppression of CatK biomarkers in urine. In this report, a previously
Externí odkaz:
https://doaj.org/article/c88a6d1ab14d4b28be9255d748dd81aa
Autor:
Jann N. Sarkaria, Nathalie Y.R. Agar, William F. Elmquist, Stuart D. Shumway, Bennett Ma, Vincenzo Pucci, Jeanette E. Eckel-Passow, Paul A. Decker, Zhenkun Lou, Debra L. Evans, Mark A. Schroeder, Brett L. Carlson, Katrina K. Bakken, Dustin Mueller, Dennis O. Iyekegbe, Shiv K. Gupta, David Calligaris, Jenny L. Pokorny
Supplementary Figure S5. MALDI-TOF MS analyses of MK-1775 (m/z 501.2)in brain and flank GBM22 tumor samples after treatment with placebo or MK-1775
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353f8a860b6932933b90938e0a9d0c07
https://doi.org/10.1158/1078-0432.22454537
https://doi.org/10.1158/1078-0432.22454537
Autor:
Jann N. Sarkaria, Nathalie Y.R. Agar, William F. Elmquist, Stuart D. Shumway, Bennett Ma, Vincenzo Pucci, Jeanette E. Eckel-Passow, Paul A. Decker, Zhenkun Lou, Debra L. Evans, Mark A. Schroeder, Brett L. Carlson, Katrina K. Bakken, Dustin Mueller, Dennis O. Iyekegbe, Shiv K. Gupta, David Calligaris, Jenny L. Pokorny
Supplementary Methods and Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd5b3cca6382f37122b6f4223c2f884
https://doi.org/10.1158/1078-0432.22454534
https://doi.org/10.1158/1078-0432.22454534
Autor:
Jann N. Sarkaria, Nathalie Y.R. Agar, William F. Elmquist, Stuart D. Shumway, Bennett Ma, Vincenzo Pucci, Jeanette E. Eckel-Passow, Paul A. Decker, Zhenkun Lou, Debra L. Evans, Mark A. Schroeder, Brett L. Carlson, Katrina K. Bakken, Dustin Mueller, Dennis O. Iyekegbe, Shiv K. Gupta, David Calligaris, Jenny L. Pokorny
Purpose: Wee1 regulates key DNA damage checkpoints, and in this study, the efficacy of the Wee1 inhibitor MK-1775 was evaluated in glioblastoma multiforme (GBM) xenograft models alone and in combination with radiation and/or temozolomide.Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e76df6db652fd16b0b9ac0d4b706f5b
https://doi.org/10.1158/1078-0432.c.6522779
https://doi.org/10.1158/1078-0432.c.6522779
Autor:
Graigory Garrett, Marian Iwamoto, Jacqueline B. McCrea, John E. Laabs, Azher Hussain, S. Aubrey Stoch, Raymond Evers, Bennett Ma
Publikováno v:
Clinical Pharmacology in Drug Development. 11:406-412
Gefapixant (MK-7264, AF-219), a first-in-class P2X3 antagonist, is being developed as oral treatment for refractory or unexplained chronic cough. Based on in vitro data, gefapixant exerts inhibitory activity on the organic anion transporter (OAT) P1B
Autor:
Jesse C. Nussbaum, Azher Hussain, Bennett Ma, K. Chris Min, Qing Chen, Charles Tomek, Marian Iwamoto, S. Aubrey Stoch
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 1, Pp n/a-n/a (2022)
Gefapixant (MK‐7264) is a first‐in‐class, selective antagonist of the P2X3 purinergic receptor currently being investigated as a therapeutic agent for the treatment of refractory or unexplained chronic cough. In non‐clinical studies, gefapixa
Autor:
Anthony Ginnetti, Daniel Paone, Kausik Nanda, Jing Li, Marina Busuek, Scott Johnson, Jun Lu, Stephen Soisson, Ronald Robinson, john Fisher, Andrea Webber, Gregg Wesolowski, Bennett Ma, Le Duong, Steven Carroll, Christopher Burgey, Shawn Stachel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 74:128927
Cathepsin K (Cat K) is a cysteine protease involved in bone remodeling. In addition to its role in bone biology, Cat K is upregulated in osteoclasts, chondrocytes and synoviocytes in osteoarthritic (OA) disease states making it a potential therapeuti
Autor:
DeDe Wohlfarth, PsyD, Daniel Sheras, MA, Jessica L. Bennett, MA, Bethany Simon, BA, Jody H. Pimentel, MS, Laura E. Gabel, MA
Publikováno v:
InSight, Vol 3, Pp 67-74 (2008)
The learner-centered paradigm departs from traditional teaching models by focusing on students more than teachers and learning more than teaching. Thus, classes are more egalitarian; they emphasize critical thinking, active learning, and real-world
Externí odkaz:
https://doaj.org/article/b94d057d6d494dadbcf0fd7c1f719b1f
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2342
There are many factors which are known to cause variability in human in vitro enzyme kinetic data. Factors such as the source of enzyme and how it was prepared, the genetics and background of the donor, how the in vitro studies are designed, and how