Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases

Autor: Henderson, Scott H., Sorrell, Fiona J., Bennett, James M., Fedorov, Oleg, Hanley, Marcus T., Godoi, Paulo H., Ruela de Sousa, Roberta, Robinson, Sean, Navratilova, Iva Hopkins, Elkins, Jonathan M., Ward, Simon E.

Publikováno v: In European Journal of Medicinal Chemistry 5 April 2024 269

An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

Autor: Haydon, David J., Stokes, Neil R., Ure, Rebecca, Galbraith, Greta, Bennett, James M., Brown, David R., Baker, Patrick J., Barynin, Vladimir V., Rice, David W., Sedelnikova, Sveta E., Heal, Jonathan R., Sheridan, Joseph M., Aiwale, Sachin T., Chauhan, Pramod K., Srivastava, Anil, Taneja, Amit, Collins, Ian, Errington, Jeff, Czaplewski, Lloyd G.

Publikováno v: Science, 2008 Sep . 321(5896), 1673-1675.

Externí odkaz: https://www.jstor.org/stable/20144845

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors

Autor: Bavetsias, Vassilios, Lanigan, Rachel M., Ruda, Gian Filippo, Atrash, Butrus, McLaughlin, Mark G., Tumber, Anthony, Mok, N. Yi, Le Bihan, Yann-Vaï, Dempster, Sally, Boxall, Katherine J., Jeganathan, Fiona, Hatch, Stephanie B., Savitsky, Pavel, Velupillai, Srikannathasan, Krojer, Tobias, England, Katherine S., Sejberg, Jimmy, Thai, Ching, Donovan, Adam, Pal, Akos, Scozzafava, Giuseppe, Bennett, James M., Kawamura, Akane, Johansson, Catrine, Szykowska, Aleksandra, Gileadi, Carina, Burgess-Brown, Nicola A., von Delft, Frank, Oppermann, Udo, Walters, Zoe, Shipley, Janet, Raynaud, Florence I., Westaway, Susan M., Prinjha, Rab K., Fedorov, Oleg, Burke, Rosemary, Schofield, Christopher J., Westwood, Isaac M., Bountra, Chas, Müller, Susanne, van Montfort, Rob L. M., Brennan, Paul E., Blagg, Julian

Publikováno v: 'Journal of Medicinal Chemistry ', vol: 59, pages: 1388-1409 (2016)
Bavetsias, V, Lanigan, R M, Ruda, G F, Atrash, B, McLaughlin, M G, Tumber, A, Mok, N Y, Le Bihan, Y V, Dempster, S, Boxall, K J, Jeganathan, F, Hatch, S B, Savitsky, P, Velupillai, S, Krojer, T, England, K S, Sejberg, J, Thai, C, Donovan, A, Pal, A, Scozzafava, G, Bennett, J M, Kawamura, A, Johansson, C, Szykowska, A, Gileadi, C, Burgess-Brown, N A, Von Delft, F, Oppermann, U, Walters, Z, Shipley, J, Raynaud, F I, Westaway, S M, Prinjha, R K, Fedorov, O, Burke, R, Schofield, C J, Westwood, I M, Bountra, C, Müller, S, Van Montfort, R L M, Brennan, P E & Blagg, J 2016, ' 8-substituted pyrido[3,4-d ]pyrimidin-4(3 H )-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors ', Journal of Medicinal Chemistry, vol. 59, no. 4, pp. 1388-1409 . https://doi.org/10.1021/acs.jmedchem.5b01635
Journal of Medicinal Chemistry

We report the discovery of N-substituted 4-(pyridin-2-yl)thiazole-2-amine derivatives and their subsequent optimization, guided by structure-based design, to give 8-(1H-pyrazol-3-yl)pyrido[3,4-d]pyrimidin-4(3H)-ones, a series of potent JmjC histone N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bbc47579e6b0a4a1af458967da196c34
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:43287

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.