Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Bennard, van Ravenzwaay"'
Autor:
Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen, Elisabet Berggren, Albert Braeuning, Wibke Busch, Christian Desaintes, Anne Gourmelon, Roland Grafström, Joshua Harrill, Thomas Hartung, Matthias Herzler, George E.N. Kass, Nicole Kleinstreuer, Marcel Leist, Mirjam Luijten, Philip Marx-Stoelting, Oliver Poetz, Bennard van Ravenzwaay, Rob Roggeband, Vera Rogiers, Adrian Roth, Pascal Sanders, Russell S. Thomas, Anne Marie Vinggaard, Mathieu Vinken, Bob van de Water, Andreas Luch, Tewes Tralau
Publikováno v:
Environment International, Vol 178, Iss , Pp 108082- (2023)
The predominantly animal-centric approach of chemical safety assessment has increasingly come under pressure. Society is questioning overall performance, sustainability, continued relevance for human health risk assessment and ethics of this system,
Externí odkaz:
https://doaj.org/article/f976f541aefc4b4e8d0e30fa3b873d98
Autor:
Robert Landsiedel, Daniela Hahn, Rainer Ossig, Sabrina Ritz, Lydia Sauer, Roland Buesen, Sascha Rehm, Wendel Wohlleben, Sibylle Groeters, Volker Strauss, Saskia Sperber, Haleluya Wami, Ulrich Dobrindt, Karola Prior, Dag Harmsen, Bennard van Ravenzwaay, Juergen Schnekenburger
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-20 (2022)
Abstract Background The oral uptake of nanoparticles is an important route of human exposure and requires solid models for hazard assessment. While the systemic availability is generally low, ingestion may not only affect gastrointestinal tissues but
Externí odkaz:
https://doaj.org/article/f44a66b7252642c58957e23656e01438
Autor:
Aishwarya Murali, Franziska Maria Zickgraf, Philipp Ternes, Varun Giri, Hunter James Cameron, Saskia Sperber, Volker Haake, Peter Driemert, Hennicke Kamp, Dorothee Funk Weyer, Shana J. Sturla, Ivonne M. G. M. Rietjens, Bennard van Ravenzwaay
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 533 (2023)
An understanding of the changes in gut microbiome composition and its associated metabolic functions is important to assess the potential implications thereof on host health. Thus, to elucidate the connection between the gut microbiome and the fecal
Externí odkaz:
https://doaj.org/article/6dbd09a7cbf24cec83d21f11e56bde9d
Autor:
Mark R. Viant, Timothy M. D. Ebbels, Richard D. Beger, Drew R. Ekman, David J. T. Epps, Hennicke Kamp, Pim E. G. Leonards, George D. Loizou, James I. MacRae, Bennard van Ravenzwaay, Philippe Rocca-Serra, Reza M. Salek, Tilmann Walk, Ralf J. M. Weber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Lack of best practice guidelines currently limits the application of metabolomics in the regulatory sciences. Here, the MEtabolomics standaRds Initiative in Toxicology (MERIT) proposes methods and reporting standards for several important application
Externí odkaz:
https://doaj.org/article/4701db2695034f70a507e741b7841422
Autor:
Aishwarya Murali, Varun Giri, Franziska Maria Zickgraf, Philipp Ternes, Hunter James Cameron, Saskia Sperber, Volker Haake, Peter Driemert, Hennicke Kamp, Dorothee Funk-Weyer, Shana J. Sturla, Ivonne M.C.M. Rietjens, Bennard van Ravenzwaay
Publikováno v:
Chemical Research in Toxicology, 36(4), 598-616
Chemical Research in Toxicology 36 (2023) 4
Chemical Research in Toxicology 36 (2023) 4
The diversity of microbial species in the gut has a strong influence on health and development of the host. Further, there are indications that the variation in expression of gut bacterial metabolic enzymes is less diverse than the taxonomic profile,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fce8df1c24b9b508f189611f46ba892
https://doi.org/10.1021/acs.chemrestox.2c00316
https://doi.org/10.1021/acs.chemrestox.2c00316
Autor:
Heike Antje Marxfeld, Karin Küttler, Martina Dammann, Sibylle Gröters, Bennard van Ravenzwaay
Publikováno v:
Data in Brief, Vol 27, Iss , Pp - (2019)
Toxicological studies were performed in an AAALAC (American Association for Laboratory Animal Care)-approved laboratory at BASF SE, Ludwigshafen, Germany, in accordance with the German Animal Welfare Act and the effective European Council Directive 2
Externí odkaz:
https://doaj.org/article/2265318b28944dac83ad2e6db6f68b84
Autor:
Sarah E. Crawford, Thomas Hartung, Henner Hollert, Björn Mathes, Bennard van Ravenzwaay, Thomas Steger-Hartmann, Christoph Studer, Harald F. Krug
Publikováno v:
Environmental Sciences Europe, Vol 29, Iss 1, Pp 1-16 (2017)
Abstract Green Toxicology refers to the application of predictive toxicology in the sustainable development and production of new less harmful materials and chemicals, subsequently reducing waste and exposure. Built upon the foundation of “Green Ch
Externí odkaz:
https://doaj.org/article/5176221402554b509cbcc8d071e4ed76
Autor:
M. Sue Marty, Ursula G. Sauer, Alex Charlton, Rashin Ghaffari, Davy Guignard, Nina Hallmark, Bethany R. Hannas, Sylvia Jacobi, Heike-Antje Marxfeld, Stephanie Melching-Kollmuss, Larry P. Sheets, Daniel Urbisch, Philip A. Botham, Bennard van Ravenzwaay
Publikováno v:
Critical Reviews in Toxicology. 52:546-617
This review investigated which patterns of thyroid- and brain-related effects are seen in rats upon gestational/lactational exposure to 14 substances causing thyroid hormone imbalance by four different modes-of-action (inhibition of thyroid peroxidas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4e5cd88f4192be7e2783a6cd19a000
https://doi.org/10.1080/10408444.2022.2130166
https://doi.org/10.1080/10408444.2022.2130166
Autor:
Sabina Ramirez-Hincapie, Barbara Birk, Philipp Ternes, Varun Giri, Volker Haake, Michael Herold, Franziska Maria Zickgraf, Andreas Verlohner, Hans-Albrecht Huener, Hennicke Kamp, Peter Driemert, Robert Landsiedel, Elke Richling, Dorothee Funk-Weyer, Bennard van Ravenzwaay
Publikováno v:
Cell Biology and Toxicology.
Cell-based metabolomics provides multiparametric physiologically relevant readouts that can be highly advantageous for improved, biologically based decision making in early stages of compound development. Here, we present the development of a 96-well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b4f900a85e866645de7a9e739b33f33
https://doi.org/10.1007/s10565-023-09809-6
https://doi.org/10.1007/s10565-023-09809-6
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology, 186(1), 18-28
Toxicological sciences : an official journal of the Society of Toxicology 186 (2022) 1
Toxicological sciences : an official journal of the Society of Toxicology 186 (2022) 1
The goal of the present study was to assess the predictive performance of a minimal generic rat physiologically based kinetic (PBK) model based on in vitro and in silico input data to predict peak plasma concentrations (Cmax) upon single oral dosing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe56a13ffa9a2b9c8bc79caf0c0ef1c6
https://doi.org/10.1093/toxsci/kfab150
https://doi.org/10.1093/toxsci/kfab150