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Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease

Autor: Bates Gillian P, Fox Helen, Benn Caroline L

Publikováno v: Molecular Neurodegeneration, Vol 3, Iss 1, p 17 (2008)

Abstract Background Transcriptional dysregulation is an early, key pathogenic mechanism in Huntington's disease (HD). Therefore, gene expression analyses have biomarker potential for measuring therapeutic efficacy in pre-clinical trials, particularly

Externí odkaz: https://doaj.org/article/9ed8ae8759a0485fa6e724e6cbfae9c3

Dysregulation of systemic soluble immune checkpoints in early breast cancer is attenuated following administration of neoadjuvant chemotherapy and is associated with recovery of CD27, CD28, CD40, CD80, ICOS and GITR and substantially increased levels of PD-L1, LAG-3 and TIM-3.

Autor: Rapoport BL; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Medical Oncology Centre of Rosebank, Johannesburg, South Africa.; Netcare Breast Care Centre, Johannesburg, South Africa., Steel HC; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Benn CA; Netcare Breast Care Centre, Johannesburg, South Africa.; Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Nayler S; Netcare Breast Care Centre, Johannesburg, South Africa.; Drs Gritzman & Thatcher Inc. Laboratories, University of the Witwatersrand Donald Gordon Medical Centre, Johannesburg, South Africa., Smit T; Medical Oncology Centre of Rosebank, Johannesburg, South Africa., Heyman L; Medical Oncology Centre of Rosebank, Johannesburg, South Africa., Theron AJ; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Hlatshwayo N; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Immunology, Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa., Kwofie LLI; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Immunology, Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa., Meyer PWA; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Immunology, Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa., Anderson R; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 Mar 30; Vol. 13, pp. 1097309. Date of Electronic Publication: 2023 Mar 30 (Print Publication: 2023).

An audit of clinically triaged women at low risk for breast cancer presenting to the Helen Joseph Mammography Unit.

Autor: Naidu LR; Department of Diagnostic Radiology, University of the Witwatersrand, South Africa., Rubin G; Department of Radiology, Helen Joseph Hospital, University of the Witwatersrand, South Africa., Benn CA; Helen Joseph Breast Care Clinic, Helen Joseph Hospital, South Africa., Govender P; Department of Radiology, Helen Joseph Hospital, University of the Witwatersrand, South Africa.

Publikováno v: South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie [S Afr J Surg] 2022 Sep; Vol. 60 (3), pp. 182-188.