Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Benjamin Zoller"'
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 7, Pp 1-15 (2015)
Abstract Mammalian transcription occurs stochastically in short bursts interspersed by silent intervals showing a refractory period. However, the underlying processes and consequences on fluctuations in gene products are poorly understood. Here, we u
Externí odkaz:
https://doaj.org/article/c45ca63a29b840e38a4c119df92bb6e6
Publikováno v:
Biophysical Journal. 122:149a-150a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e2777b9cd756b30796904423a42c5d
https://doi.org/10.1016/j.bpj.2022.11.1006
https://doi.org/10.1016/j.bpj.2022.11.1006
Publikováno v:
Current Opinion in Systems Biology
Current Opinion in Systems Biology, 2022, 31, pp.100435. ⟨10.1016/j.coisb.2022.100435⟩
Current Opinion in Systems Biology, 2022, 31, pp.100435. ⟨10.1016/j.coisb.2022.100435⟩
Models of transcriptional regulation that assume equilibrium binding of transcription factors have been very successful at predicting gene expression from sequence in bacteria. However, analogous equilibrium models do not perform as well in eukaryote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38942945cc9bcf19137de8accdbc281e
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Simple biophysical models successfully describe bacterial regulatory code, by predicting gene expression from DNA sequences that bind specialized regulatory proteins. Analogous simple models fail in multicellular organisms, where regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b909e241014ec3a60a185137a23903
https://pubmed.ncbi.nlm.nih.gov/33268497
https://pubmed.ncbi.nlm.nih.gov/33268497
In prokaryotes, thermodynamic models of gene regulation provide a highly quantitative mapping from promoter sequences to gene expression levels that is compatible with in vivo and in vitro bio-physical measurements. Such concordance has not been achi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed595df6e672b7d99ac6663e28bcca3e
https://doi.org/10.1101/2020.04.08.029405
https://doi.org/10.1101/2020.04.08.029405
Publikováno v:
Biophysical Journal. 120:135a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0768b3885d5475962d4f69b1859e39b
https://doi.org/10.1016/j.bpj.2020.11.1016
https://doi.org/10.1016/j.bpj.2020.11.1016
Publikováno v:
Cell
Cell, 2018, 175 (3), pp.835-847.e25. ⟨10.1016/j.cell.2018.09.056⟩
Cell, 2018, 175 (3), pp.835-847.e25. ⟨10.1016/j.cell.2018.09.056⟩
International audience; How transcriptional bursting relates to gene regulation is a central question that has persisted for more than a decade. Here, we measure nascent transcriptional activity in early Drosophila embryos and characterize the variab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9702d16da44d21e08a8bd569dd5986e
https://hal-pasteur.archives-ouvertes.fr/pasteur-03869446
https://hal-pasteur.archives-ouvertes.fr/pasteur-03869446
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(27)
Many mammalian genes are transcribed during short bursts of variable frequencies and sizes that substantially contribute to cell-to-cell variability. However, which molecular mechanisms determine bursting properties remains unclear. To probe putative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e810e0a90934fa115db3aa9aee8027
https://pubmed.ncbi.nlm.nih.gov/29915087
https://pubmed.ncbi.nlm.nih.gov/29915087
Publikováno v:
Proceedings of the National Academy of Sciences
Significance Recent single-cell studies showed that gene transcription in mammals is fundamentally stochastic, occurring in short and intense transcriptional bursts. However, less is known on how transcriptional bursting is modulated upon stimulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be293a673e276a2f01cef14c2d77ca4e
https://doi.org/10.1073/pnas.1312310110
https://doi.org/10.1073/pnas.1312310110
Autor:
Felix Naef, Carinne Gubelmann, Jovan Simicevic, Benjamin Zoller, Bart Deplancke, Irina Krier, Paola Gilardoni, Frédérique Lisacek, Marc Moniatte, Sunil K. Raghav, Adrien W. Schmid
The cellular abundance of transcription factors (TFs) is an important determinant of their regulatory activities. Deriving TF copy numbers is therefore crucial to understanding how these proteins control gene expression. We describe a sensitive selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca9832d4c8e1b3947965a52022a0e65
https://doi.org/10.5167/uzh-78970
https://doi.org/10.5167/uzh-78970