Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Benjamin Wolozin"'
Autor:
Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Jenna Libera, Zihan Wang, Alper Kilci, Matthew Jenkins, Alejandro Rondón Ortiz, Luke Dorrian, Jingjing Sun, Guangxin Sun, Sherif Rashad, Caroline Kornbrek, Sarah Anne Daley, Peter C. Dedon, Brian Nguyen, Weiming Xia, Takashi Saito, Takaomi C. Saido, Benjamin Wolozin
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionThe study of the pathophysiology study of Alzheimer’s disease (AD) has been hampered by lack animal models that recapitulate the major AD pathologies, including extracellular -amyloid (A) deposition, intracellular aggregation of microtu
Externí odkaz:
https://doaj.org/article/b7557e4ad4e346968ea1ea10bd07ae48
Autor:
Jian Zhao, Lulu Jiang, Alex Matlock, Yihong Xu, Jiabei Zhu, Hongbo Zhu, Lei Tian, Benjamin Wolozin, Ji-Xin Cheng
Publikováno v:
Light: Science & Applications, Vol 12, Iss 1, Pp 1-16 (2023)
Abstract Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases. However, it remains a grand challenge to extract molecular structure information from intracellular amyloid proteins in their native cellular environment. T
Externí odkaz:
https://doaj.org/article/6d8c075c28a14f669662c1db77e2031b
Autor:
Jinyoung Park, Yanwei Wu, Wei Shao, Tania F. Gendron, Sophie J.F. van der Spek, Grigorii Sultanakhmetov, Avik Basu, Paula Castellanos Otero, Caroline J. Jones, Karen Jansen-West, Lillian M. Daughrity, Sadhna Phanse, Giulia del Rosso, Jimei Tong, Monica Castanedes-Casey, Lulu Jiang, Jenna Libera, Björn Oskarsson, Dennis W. Dickson, David W. Sanders, Clifford P. Brangwynne, Andrew Emili, Benjamin Wolozin, Leonard Petrucelli, Yong-Jie Zhang
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112822- (2023)
Summary: C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly(GR) proteins are toxic to neurons by forming cytoplasmic inclusions that sequester RNA-binding protein
Externí odkaz:
https://doaj.org/article/b8020317518447719952eee97c008bca
Autor:
Hannah Drew Rickner, Lulu Jiang, Rui Hong, Nicholas K. O’Neill, Chromewell A. Mojica, Benjamin J. Snyder, Lushuang Zhang, Dipan Shaw, Maria Medalla, Benjamin Wolozin, Christine S. Cheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Single cell RNA-sequencing of the AstTau neuron-asteroid tau assembloid model reveals excitatory neuron inflammatory signatures and an astrocytic heat shock response similar to that occurring in the brains of individuals with tauopathies, which can b
Externí odkaz:
https://doaj.org/article/c2f626bbe8c54805b65ee8e67aecb7a3
Autor:
Mingfei Li, Joel Reisman, Benjamin Morris-Eppolito, Shirley X. Qian, Lewis E. Kazis, Benjamin Wolozin, Lee E. Goldstein, Weiming Xia
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2020)
Abstract Background Pathological analysis of brain tissue from animals and humans with a history of traumatic brain injury (TBI) suggests that TBI could be one of the risk factors facilitating onset of dementia with possible Alzheimer’s disease (AD
Externí odkaz:
https://doaj.org/article/0195a76769274780b024d3c92bcbe4f1
Autor:
Mirco Masi, Alessandro Attanzio, Marco Racchi, Benjamin Wolozin, Sofia Borella, Fabrizio Biundo, Erica Buoso
Publikováno v:
Cells, Vol 11, Iss 16, p 2590 (2022)
The role of protein misfolding, deposition, and clearance has been the dominant topic in the last decades of investigation in the field of neurodegeneration. The impairment of protein synthesis, along with RNA metabolism and RNA granules, however, ar
Externí odkaz:
https://doaj.org/article/0185cb0d87de4527bf3f3d6528d445bf
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Tau aggregates are pleiotropic and exhibit differences in conformation, structure, and size. These aggregates develop endogenously but are also propagated among neurons in disease. We explored the actions of two distinct types of tau aggregates, tau
Externí odkaz:
https://doaj.org/article/8e30992be7df4d41b2a35d9491cfd7e3
Autor:
Chelsey Jenna LeBlang, Maria Medalla, Nicholas William Nicoletti, Emma Catherine Hays, James Zhao, Jenifer Shattuck, Anna Lourdes Cruz, Benjamin Wolozin, Jennifer Irene Luebke
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Neuroinflammatory processes play an integral role in the exacerbation and progression of pathology in tauopathies, a class of neurodegenerative disease characterized by aggregation of hyperphosphorylated tau protein. The RNA binding protein (RBP) T-c
Externí odkaz:
https://doaj.org/article/1520928ad2884e0c981f19436532c967
Autor:
Daniel J. Apicco, Cheng Zhang, Brandon Maziuk, Lulu Jiang, Heather I. Ballance, Samantha Boudeau, Choong Ung, Hu Li, Benjamin Wolozin
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4377-4388.e4 (2019)
Summary: Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer’s disease brain tissues. The dysregulated splicing particularly affects genes invol
Externí odkaz:
https://doaj.org/article/014cdf558eef489792b24f7919c478ba
Autor:
Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F. Abisambra, Hu Li, Benjamin Wolozin
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer’s disease (AD). Accumulating evidence suggests that tau pathol
Externí odkaz:
https://doaj.org/article/1ff29ffa3bc645ae9a23707f55eb60f2