Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Benjamin W. Spiller"'
Autor:
Justin R. Haynes, Clayton A. Whitmore, William J. Behof, Charlotte A. Landman, Henry H. Ong, Andrew P. Feld, Isabelle C. Suero, Celeste B. Greer, John C. Gore, Printha Wijesinghe, Joanne A. Matsubara, Brian E. Wadzinski, Benjamin W. Spiller, Wellington Pham
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The classical amyloid cascade hypothesis postulates that the aggregation of amyloid plaques and the accumulation of intracellular hyperphosphorylated Tau tangles, together, lead to profound neuronal death. However, emerging research has demo
Externí odkaz:
https://doaj.org/article/c762f9905491477abe67360110002bce
Autor:
Clayton A. Whitmore, Justin R. Haynes, William J. Behof, Adam J. Rosenberg, Mohammed N. Tantawy, Brian C. Hachey, Brian E. Wadzinski, Benjamin W. Spiller, Todd E. Peterson, Krista C. Paffenroth, Fiona E. Harrison, Robert B. Beelman, Printha Wijesinghe, Joanne A. Matsubara, Wellington Pham
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 742 (2022)
Background: Ergothioneine (ERGO) is a unique antioxidant and a rare amino acid available in fungi and various bacteria but not in higher plants or animals. Substantial research data indicate that ERGO is a physiological antioxidant cytoprotectant. Di
Externí odkaz:
https://doaj.org/article/882ef7134def4279bbf43586617325cc
Autor:
Azadeh Hadadianpour, Jacob Daniel, Jian Zhang, Benjamin W. Spiller, Asta Makaraviciute, Åsa M. DeWitt, Heather S. Walden, Robert G. Hamilton, R. Stokes Peebles, Thomas B. Nutman, Scott A. Smith
Publikováno v:
Journal of Allergy and Clinical Immunology. 150:1525-1533
Much of our understanding of the targets of IgE comes from studies of allergy, though little is known about the natural immunogenic targets seen after parasitic worm infections.We used human monoclonal antibodies (mAbs) for an unbiased and comprehens
Autor:
Jean-Marie Sontag, Diana Schuhmacher, Goce Taleski, Anthony Jordan, Sarah Khan, Alexander Hoffman, Rey J. Gomez, Matthew D. Mazalouskas, Steven K. Hanks, Benjamin W. Spiller, Estelle Sontag, Brian E. Wadzinski
Publikováno v:
The Journal of biological chemistry. 298(8)
Protein phosphatase 2A (PP2A) is a major phospho-Ser/Thr phosphatase and a key regulator of cellular signal transduction pathways. While PP2A dysfunction has been linked to human cancer and neurodegenerative disorders such as Alzheimer's disease (AD)
Autor:
Tara L Archuleta, Benjamin W Spiller
Publikováno v:
PLoS Pathogens, Vol 10, Iss 11, p e1004498 (2014)
Many Gram-negative bacteria use Type Three Secretion Systems (T3SS) to deliver effector proteins into host cells. These protein delivery machines are composed of cytosolic components that recognize substrates and generate the force needed for translo
Externí odkaz:
https://doaj.org/article/c290f60d63ee45e4acd104a2d631a910
Autor:
Mohammed S Aiyegbo, Gopal Sapparapu, Benjamin W Spiller, Ilyas M Eli, Dewight R Williams, Robert Kim, David E Lee, Tong Liu, Sheng Li, Virgil L Woods, David P Nannemann, Jens Meiler, Phoebe L Stewart, James E Crowe
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61101 (2013)
Several live attenuated rotavirus (RV) vaccines have been licensed, but the mechanisms of protective immunity are still poorly understood. The most frequent human B cell response is directed to the internal protein VP6 on the surface of double-layere
Externí odkaz:
https://doaj.org/article/d90e29a9134149ab94b8e00efa12fec7
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008923 (2020)
PLoS Pathogens, Vol 16, Iss 10, p e1008923 (2020)
Type III protein secretion systems (T3SS) deliver effector proteins from the Gram-negative bacterial cytoplasm into a eukaryotic host cell through a syringe-like, multi-protein nanomachine. Cytosolic components of T3SS include a portion of the export
Autor:
McKenzie King, Melissa A. Farrow, Benjamin W. Spiller, John A. Shupe, Sarah C. Bloch, Kaycei Moton-Melancon, Nicole M. Chumber, D. Borden Lacy, Mary Kay Washington
Publikováno v:
ACS Chem Biol
Clostridioides difficile is the leading cause of nosocomial diarrhea in the United States. The primary virulence factors are two homologous sglucosyltransferase toxins, TcdA and TcdB, that inactivate host Rho-family GTPases. The glucosyltransferase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc73c87bf52e2809cf36861a6dc889f9
https://europepmc.org/articles/PMC7230009/
https://europepmc.org/articles/PMC7230009/
Publikováno v:
Nature Immunology. 20:1559-1561
Acid sphingomyelinase deficiency, which prevents degradation of sphingomyelin (SM), causes lysosomal SM overload both in mice and in patients with Niemann–Pick disease A or B. Altered cellular SM homeostasis disrupts the development and function of
Autor:
D. Borden Lacy, Heather K. Kroh, Benjamin W. Spiller, Melanie D. Ohi, G. Jonah A. Rainey, Kim Rosenthal, Robert M. Woods, Paul Warrener, Ramyavardhanee Chandrasekaran, Xiaofang Jin, Andrew C. Nyborg
Publikováno v:
Journal of Biological Chemistry. 292:14401-14412
Clostridium difficile is a clinically significant pathogen that causes mild-to-severe (and often recurrent) colon infections. Disease symptoms stem from the activities of two large, multidomain toxins known as TcdA and TcdB. The toxins can bind, ente