Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Benjamin W. Purow"'
Autor:
Hye-Min Jeon, Yong Jae Shin, Jaehyun Lee, Nakho Chang, Dong-Hun Woo, Won Jun Lee, Dayna Nguyen, Wonyoung Kang, Hee Jin Cho, Heekyoung Yang, Jin-Ku Lee, Jason K. Sa, Yeri Lee, Dong Geon Kim, Benjamin W. Purow, Yeup Yoon, Do-Hyun Nam, Jeongwu Lee
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Glioblastoma (GBM) is the most lethal brain cancer with a dismal prognosis. Stem-like GBM cells (GSCs) are a major driver of GBM propagation and recurrence; thus, understanding the molecular mechanisms that promote GSCs may lead to effective therapeu
Externí odkaz:
https://doaj.org/article/8ea1cbbe2cb049948a953837f0efb51e
Autor:
Laryssa C. Manigat, Mitchell E. Granade, Suchet Taori, Charlotte Anne Miller, Luke R. Vass, Xiao-Ping Zhong, Thurl E. Harris, Benjamin W. Purow
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The diacylglycerol kinases (DGKs) are a family of enzymes responsible for the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). In addition to their primary function in lipid metabolism, DGKs have recently been identified as potential the
Externí odkaz:
https://doaj.org/article/5ba88728e8134ec2bb0acf93d24cdecf
Autor:
Patrick Y. Wen, Keith L. Ligon, Tracy T. Batchelor, Rakesh K. Jain, Katrina H. Smith, Mary Gerard, Christine S. McCluskey, Brian M. Alexander, Stephanie E. Weiss, Rameen Beroukhim, Andrew D. Norden, Jan Drappatz, Shakti Ramkissoon, Jason T. Huse, Marek Ancukiewicz, Alona Muzikansky, Benjamin W. Purow, Tom Mikkelsen, Eric T. Wong, Andrew B. Lassman, David Schiff, Dan G. Duda, Thomas J. Kaley, Eudocia Q. Lee
Supplemental Figure: Mean plasma concentrations of vandetanib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb53b7e4a9ef2c63a8a0064d98ef2363
https://doi.org/10.1158/1078-0432.22456728
https://doi.org/10.1158/1078-0432.22456728
Autor:
Patrick Y. Wen, Keith L. Ligon, Tracy T. Batchelor, Rakesh K. Jain, Katrina H. Smith, Mary Gerard, Christine S. McCluskey, Brian M. Alexander, Stephanie E. Weiss, Rameen Beroukhim, Andrew D. Norden, Jan Drappatz, Shakti Ramkissoon, Jason T. Huse, Marek Ancukiewicz, Alona Muzikansky, Benjamin W. Purow, Tom Mikkelsen, Eric T. Wong, Andrew B. Lassman, David Schiff, Dan G. Duda, Thomas J. Kaley, Eudocia Q. Lee
Supplemental Tables 1-3. Supplementary Table 1: Correlations in the vandetanib/RT/TMZ arm between best radiographic responses with pre-treatment and on-treatment changes in blood biomarkers. Supplementary Table 2: Correlations in the vandetanib/RT/TM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d38071c2c0d2497fbee5217e5d023c
https://doi.org/10.1158/1078-0432.22456725.v1
https://doi.org/10.1158/1078-0432.22456725.v1
Autor:
Desiree Hunt Floyd, Ying Zhang, Bijan K Dey, Benjamin Kefas, Hannah Breit, Kaitlyn Marks, Anindya Dutta, Christel Herold-Mende, Michael Synowitz, Rainer Glass, Roger Abounader, Benjamin W Purow
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96239 (2014)
Glioblastoma is the most common and lethal primary brain tumor. Tumor initiation and recurrence are likely caused by a sub-population of glioblastoma stem cells, which may derive from mutated neural stem and precursor cells. Since CD133 is a stem cel
Externí odkaz:
https://doaj.org/article/362465ad5df24615822dd299c070b551
Autor:
Ryon H Clarke, Shayan Moosa, Matthew Anzivino, Yi Wang, Desiree Hunt Floyd, Benjamin W Purow, Kevin S Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111199 (2014)
Glioblastoma multiforme (GBM) is the most common and lethal form of brain cancer and these tumors are highly resistant to chemo- and radiotherapy. Radioresistance is thought to result from a paucity of molecular oxygen in hypoxic tumor regions, resul
Externí odkaz:
https://doaj.org/article/49a342b3977f45ba9fa23ab246170eaf
Autor:
Mitchell E. Granade, Laryssa C. Manigat, Michael C. Lemke, Benjamin W. Purow, Thurl E. Harris
Publikováno v:
Biochem Pharmacol
The diacylglycerol kinase (DGK) family of lipid enzymes catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). Both DAG and PA are lipid signaling molecules that are of notable importance in regulating cell processes such as prol
Publikováno v:
Journal of Virological Methods. 65:287-298
We demonstrate that from the CaSki cervical cancer cell line, integrated HPV-16 genome was amplified and viral-like particles were generated in an in vivo SCID mouse model. The in vivo tumor growth of several HPV-containing cell lines and 2 HPV-negat
Autor:
Benjamin W, Purow, David, Schiff
Publikováno v:
Discovery medicine. 9(45)
Glioblastoma is the most common and most lethal primary brain tumor. While small progress has been made in treating this cancer in recent years, glioblastoma remains largely resistant to all existing therapies. It has been hoped that dissection of th
Autor:
David, Schiff, Benjamin W, Purow
Publikováno v:
Nature reviews. Neurology. 5(6)
Most grade II and grade III gliomas, as well as the secondary glioblastomas that arise from these tumors, possess point mutations that affect the substrate binding site of isocitrate dehydrogenase. These mutations are essentially unique to gliomas, s