Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Benjamin W. Blake"'
Publikováno v:
Chemosphere. 31:2499-2510
Statistically significant quantitative structure-toxicity relationship (QSTR) models have been developed for assessing developmental toxicity potential (DTP) of chemicals. Three submodels, one each for aliphatic, heteroaromatic and carboaromatic comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d32b48023b84874b2f9d18f9cf3a05b
https://doi.org/10.1016/0045-6535(95)00119-s
https://doi.org/10.1016/0045-6535(95)00119-s
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 305:47-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3eb585dfae3f75f1c54288518bc03b9
https://doi.org/10.1016/0027-5107(94)90125-2
https://doi.org/10.1016/0027-5107(94)90125-2
Publikováno v:
Risk Analysis. 11:509-517
A quantitative structure-activity relationship (QSAR) model has been developed to estimate maximum tolerated doses (MTD) from structural features of chemicals and the corresponding oral acute lethal doses (LD50) as determined in male rats. The model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef55e118323f2121d40fd6c4fd8d7437
https://doi.org/10.1111/j.1539-6924.1991.tb00636.x
https://doi.org/10.1111/j.1539-6924.1991.tb00636.x
Publikováno v:
Quantitative Structure-Activity Relationships. 10:306-332
Four related QSAR models of teratogenesis in experimental animals have been developed: one each for heteroaromatic, carboaromatic, alicyclic and acyclic compounds. The numbers of compounds in these models range from 40 (for the alicyclic model) to 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dd1b57803937796e1f1af5eb63badd5
https://doi.org/10.1002/qsar.19910100404
https://doi.org/10.1002/qsar.19910100404
Publikováno v:
Mutation Research/Genetic Toxicology. 241:261-271
Based on a compilation of 222 reports of rodent nominal lifetime carcinogenicity bioassays by the NCI/NTP on the one hand, and corresponding Salmonella mutagenicity bioassays (Ames tests) on the other, Ashby and Tennant (1988) have divided the carcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69078df42ff2a692bb9d9dda20391c62
https://doi.org/10.1016/0165-1218(90)90023-u
https://doi.org/10.1016/0165-1218(90)90023-u
Autor:
Benjamin W. Blake, Bagheri D, Vijay K. Gombar, Jurij J. Hostynek, C.C Sigman, Howard I. Maibach, Kurt Enslein
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 35(10-11)
We have developed quantitative structure-toxicity relationship (QSTR) models for assessing dermal sensitization using guinea pig maximization test (GPMT) results. The models are derived from 315 carefully evaluated chemicals. There are two models, on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d11c1897345e52aa67cd18e4366d7f5
https://pubmed.ncbi.nlm.nih.gov/9463544
https://pubmed.ncbi.nlm.nih.gov/9463544
Autor:
Benjamin W. Blake, K.I. Huque, V.M.S. Ramanujam, L.A. Knauf, D.J. Reisman, C.T. DeRosa, Vijay K. Gombar, J.R. Carter, M.M. Mumtaz, W.B. Peirano, Kurt Enslein
Publikováno v:
Toxicology letters. 79(1-3)
With the multitude of new chemicals being synthesized and the paucity of long-term test data on chemicals that could be introduced into the environment, innovative approaches must be developed to determine the health and environmental effects of chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27153ce6d78ec88c1f1d58735cd2aed
https://pubmed.ncbi.nlm.nih.gov/7570650
https://pubmed.ncbi.nlm.nih.gov/7570650
Publikováno v:
Mutagenesis. 5:305-306
Forty-four compounds currently undergoing carcinogenesis bioassay by the National Toxicology Program were submitted to the TOPKAT program for prediction of their potential carcinogenicity. Sixteen compounds could not be handled by TOPKAT. Of the 28 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb284093f62b27e3d543085962022c5c
https://doi.org/10.1093/mutage/5.4.305
https://doi.org/10.1093/mutage/5.4.305
Publikováno v:
Toxicology and Industrial Health. 3:267-287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d24b651412e22d0ef5adb879f4d4224
https://doi.org/10.1177/074823378700300109
https://doi.org/10.1177/074823378700300109
Publikováno v:
QSAR in Environmental Toxicology-II ISBN: 9789401082464
A structure-activity model (QSAR) of rat oral LD50 toxicity based on Daphnia magna LC50 values and structural parameters has been developed. Even though the two species represent widely different animals, it is possible to achieve reasonably good pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e92c5bf69a7cb509fb98badb695a9758
https://doi.org/10.1007/978-94-009-3937-0_9
https://doi.org/10.1007/978-94-009-3937-0_9
