Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Benjamin Uzan"'
Autor:
Charly Le Maout, Lucine Fahy, Laurent Renou, Caroline Devanand, Charlotte Duwat, Vilma Barroca, Morgane Le Gall, Paola Ballerini, Arnaud Petit, Julien Calvo, Benjamin Uzan, Françoise Pflumio, Vanessa Petit
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117039- (2024)
T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematological disorder characterized by an increased proliferation of immature T lymphocytes precursors. T-ALL treatment includes chemotherapy with strong side effects, and patients that unde
Externí odkaz:
https://doaj.org/article/748772012bac470fa770cc7769552b6a
Autor:
Etienne Delangre, Gaëlle Pommier, Stefania Tolu, Benjamin Uzan, Danielle Bailbé, Jamileh Movassat
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114895- (2023)
Background and purpose: Glucocorticoids (GCs) are the main treatment for autoimmune and inflammatory disorders and are also used as immunosuppressive therapy for patients with organ transplantation. However, these treatments have several side effects
Externí odkaz:
https://doaj.org/article/1287878218a94bb2999215d7e626ee8b
Autor:
Tra Ly Nguyen, Marie‐Julie Nokin, Silvia Terés, Mercedes Tomé, Clément Bodineau, Oriane Galmar, Jean‐Max Pasquet, Benoit Rousseau, Sebastian vanLiempd, Juan Manuel Falcon‐Perez, Elodie Richard, Elodie Muzotte, Hamid‐Reza Rezvani, Muriel Priault, Marion Bouchecareilh, Isabelle Redonnet‐Vernhet, Julien Calvo, Benjamin Uzan, Françoise Pflumio, Patricia Fuentes, Maria L. Toribio, Abdel‐Majid Khatib, Pierre Soubeyran, Piedad del Socorro Murdoch, Raúl V. Durán
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1412-1431 (2021)
The cellular receptor Notch1 is a central regulator of T‐cell development, and as a consequence, Notch1 pathway appears upregulated in > 65% of the cases of T‐cell acute lymphoblastic leukemia (T‐ALL). However, strategies targeting Notch1 signa
Externí odkaz:
https://doaj.org/article/35c04b323d3d4645a1349eaea077bcd1
Autor:
Xavier Cahu, Julien Calvo, Sandrine Poglio, Nais Prade, Benoit Colsch, Marie-Laure Arcangeli, Thierry Leblanc, Arnaud Petit, Frederic Baleydier, Andre Baruchel, Judith Landman-Parker, Christophe Junot, Jerome Larghero, Paola Ballerini, Eric Delabesse, Benjamin Uzan, Francoise Pflumio
Publikováno v:
Blood Advances, Vol 1, Iss 20, Pp 1760-1772 (2017)
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) expands in various bone marrow (BM) sites of the body. We investigated whether different BM sites could differently modulate T-ALL propagation using in vivo animal models. We observed that mouse a
Externí odkaz:
https://doaj.org/article/8a5ab4bef29543e99f617e6cbae7c387
Autor:
Laurent Renou, Pierre-Yves Boelle, Caroline Deswarte, Salvatore Spicuglia, Aissa Benyoucef, Julien Calvo, Benjamin Uzan, Mohamed Belhocine, Agata Cieslak, Judith Landman-Parker, Andre Baruchel, Vahid Asnafi, Françoise Pflumio, Paola Ballerini, Irina Naguibneva
Publikováno v:
Blood Advances, Vol 1, Iss 12, Pp 733-747 (2017)
Abstract: The oncogenic mechanisms driven by aberrantly expressed transcription factors in T-cell acute leukemia (T-ALL) are still elusive. MicroRNAs (miRNAs) play an important role in normal development and pathologies. Here, we examined the express
Externí odkaz:
https://doaj.org/article/53f4fbc4399d4fcdb34c7c0364a0ba4f
Autor:
Sara Chabi, Benjamin Uzan, Irina Naguibneva, Julien Rucci, Lucine Fahy, Julien Calvo, Marie-Laure Arcangeli, Frédéric Mazurier, Françoise Pflumio, Rima Haddad
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2307-2320.e6 (2019)
Summary: Hypoxia plays a major role in the physiology of hematopoietic and immune niches. Important clues from works in mouse have paved the way to investigate the role of low O2 levels in hematopoiesis. However, whether hypoxia impacts the initial s
Externí odkaz:
https://doaj.org/article/c5ad5331cf22437896b3c52e4ad2f578
Autor:
Benjamin Uzan, Sandrine Poglio, Bastien Gerby, Ching‐Lien Wu, Julia Gross, Florence Armstrong, Julien Calvo, Xavier Cahu, Caroline Deswarte, Florent Dumont, Diana Passaro, Corinne Besnard‐Guérin, Thierry Leblanc, André Baruchel, Judith Landman‐Parker, Paola Ballerini, Véronique Baud, Jacques Ghysdael, Frédéric Baleydier, Francoise Porteu, Francoise Pflumio
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 6, Pp 821-834 (2014)
Abstract Development of novel therapies is critical for T‐cell acute leukaemia (T‐ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T‐ALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70% of
Externí odkaz:
https://doaj.org/article/7da05d3e2efb44aeb069f4d5b6f9f963
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4734 (2009)
BACKGROUND: Keratinocyte growth factor (KGF; palifermin) is a growth factor with a high degree of specificity for epithelial cells. KGF is an important effector of epithelial growth and tissue homeostasis in various organs including the pancreas. Her
Externí odkaz:
https://doaj.org/article/c56055c7ee364ff6bf413afa98ba1892
Autor:
Clément Bodineau, Benjamin Uzan, Sebastian van Liempd, Jean-Max Pasquet, Juan M. Falcón-Pérez, Elodie Muzotte, H. Rezvani, Julien Calvo, Elodie Richard, María L. Toribio, Patricia Fuentes, Isabelle Redonnet-Vernhet, Silvia Terés, Marion Bouchecareilh, Mercedes Tomé, Pierre Soubeyran, Piedad del Socorro Murdoch, Benoit Rousseau, Tra Ly Nguyen, Françoise Pflumio, Marie-Julie Nokin, Oriane Galmar, Raúl V. Durán, Abdel-Majid Khatib, Muriel Priault
Publikováno v:
Molecular Oncology
Molecular Oncology, Elsevier, 2021, 15 (5), pp.1412-1431. ⟨10.1002/1878-0261.12877⟩
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Molecular Oncology, Elsevier, 2021, 15, pp.1412-1431. ⟨10.1002/1878-0261.12877⟩
Digital.CSIC. Repositorio Institucional del CSIC
Molecular Oncology, Vol 15, Iss 5, Pp 1412-1431 (2021)
Molecular Oncology, Elsevier, 2021, 15 (5), pp.1412-1431. ⟨10.1002/1878-0261.12877⟩
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Molecular Oncology, Elsevier, 2021, 15, pp.1412-1431. ⟨10.1002/1878-0261.12877⟩
Digital.CSIC. Repositorio Institucional del CSIC
Molecular Oncology, Vol 15, Iss 5, Pp 1412-1431 (2021)
During glutamine sufficiency, both Notch‐positive and Notch‐negative T‐ALL cells promote glutamine catabolism, leading to mammalian target of rapamycin complex 1 (mTORC1) activation and cell growth and proliferation. However, during glutamine s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274dd93100a7d24ada66a7c0aca2aad0
https://hal-cnrs.archives-ouvertes.fr/hal-03401225
https://hal-cnrs.archives-ouvertes.fr/hal-03401225
Autor:
Silvia Salmoiraghi, Daniel Birnbaum, Loïc Garçon, Frederik Otzen Bagger, Zakia Aid, Alexandre Fagnan, Benjamin Uzan, Stephane de Botton, Maria Riera Piqué-Borràs, Cécile K. Lopez, Christine Dierks, Connor Sweeney, Eric Delabesse, Juerg Schwaller, Elie Robert, Kazuya Shimoda, Zahra Kadri, Thomas Pabst, Jaroslaw P. Maciejewski, Betty Leite, Alexis Caulier, Sébastien Malinge, Samantha Tauchmann, Catherine Carmichael, Amina Kurtovic-Kozaric, Olivier A. Bernard, Virginie Deleuze, Ute M. Moll, Paresh Vyas, Martin Carroll, Veronique De Mas, Orietta Spinelli, Thomas Mercher, Hélène Lapillonne, Cathy Ignacimouttou, Charles G. Mullighan, Eric Soler, V. Gelsi-Boyer, Peter Valent, Cécile Thirant, Jean Baptiste Micol, Eduardo Anguita, Ilaria Iacobucci, Benjamin T. Kile
Publikováno v:
Blood
Blood, American Society of Hematology, 2020, 136 (6), pp.698-714. ⟨10.1182/blood.2019003062⟩
Blood, American Society of Hematology, 2020, 136 (6), pp.698-714. ⟨10.1182/blood.2019003062⟩
Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. To better
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1611df63d3e6c6a4c23f7a9b703562
https://hal.archives-ouvertes.fr/hal-03022044/document
https://hal.archives-ouvertes.fr/hal-03022044/document