Výsledky vyhledávání - "Benjamin Tubb"

A Phase II, Multicenter, Single-Arm Study of Mipsagargin (G-202) as a Second-Line Therapy Following Sorafenib for Adult Patients with Progressive Advanced Hepatocellular Carcinoma

Autor: Luis T. Campos, Julio Peguero, Julie Rowe, Victoria Allgood, Putao Cen, Benjamin Tubb, Devalingam Mahalingam, Sukeshi Patel Arora, John Sarantopoulos

Publikováno v: Cancers
Cancers, Vol 11, Iss 6, p 833 (2019)
Volume 11
Issue 6

Background: Mipsagargin (G-202) is a thapsigargin-based prodrug with cytotoxic activity masked by a peptide that is cleaved by prostate-specific membrane antigen (PSMA), a protease expressed in prostate cancer cells and the endothelium of tumor vascu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886b61ec6ac320b44401d7b95e52573e
http://europepmc.org/articles/PMC6627768

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Testis Fascin (FSCN3): A Novel Paralog of the Actin-Bundling Protein Fascin Expressed Specifically in the Elongate Spermatid Head

Autor: Benjamin Tubb, Wayne Vogl, Zi-Jian Lan, Austin J. Cooney, Craig Niederberger, David J. Mulholland, Joseph Bryan

Publikováno v: Experimental Cell Research. 275:92-109

During spermiogenesis, significant morphological changes occur as round spermatids are remodeled into the fusiform shape of mature spermatozoa. These changes are correlated with a reorganization of microfilaments and microtubules in the head and tail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01b3b4587ba9d6d1acacfb66ce59c30
https://doi.org/10.1006/excr.2002.5486

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Clinical activity and correlative DCE-MRI imaging of G-202, a thapsigargin-based prostate-specific membrane antigen-activated prodrug, in progressive hepatocellular cancer

Autor: Putao Cen, Luis T. Campos, Benjamin Tubb, Michael R. Kurman, Victoria Allgood, John Sarantopoulos, Devalingam Mahalingam, John Nemunaitis, Julie Rowe

Publikováno v: Journal of Clinical Oncology. 33:301-301

301 Background: G-202 is a thapsigargin-based prodrug whose cytotoxic activity is blocked by a masking peptide that is cleaved by prostate-specific membrane antigen (PSMA), a membrane-bound protease expressed in prostate cancer and the endothelium of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbbe1dd842a1d9c74e94c8ccc96f9bed
https://doi.org/10.1200/jco.2015.33.3_suppl.301

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