Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Benjamin T. Spike"'
Autor:
Jonathan A. Kelber, Marcin Iwanicki, Marianna Kruithof-de Julio, Benjamin T. Spike, Michelle M. Martínez-Montemayor
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/efb0931fd4e049bbb58307e3133141c7
Autor:
Edward R. Polanco, Tarek E. Moustafa, Andrew Butterfield, Sandra D. Scherer, Emilio Cortes-Sanchez, Tyler Bodily, Benjamin T. Spike, Bryan E. Welm, Philip S. Bernard, Thomas A. Zangle
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The authors developed a real-time and label-free approach based on quantitative phase imaging to determine drug sensitivity with significant advantages over endpoint viability or metabolic assays, and which reveals single cell response heterogeneity.
Externí odkaz:
https://doaj.org/article/bdafcd4216674d5e8612300cafe2762b
Autor:
Manish Ranjan, Oukseub Lee, Gannon Cottone, Elnaz Mirzaei Mehrabad, Benjamin T. Spike, Zexian Zeng, Shivangi Yadav, Robert Chatterton, J. Julie Kim, Susan E. Clare, Seema A. Khan
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-17 (2021)
Abstract Background The ovarian hormones estrogen and progesterone (EP) are implicated in breast cancer causation. A specific consequence of progesterone exposure is the expansion of the mammary stem cell (MSC) and luminal progenitor (LP) compartment
Externí odkaz:
https://doaj.org/article/54ebd66fced14276b1e7e69565c3d521
Autor:
Ozlen Balcioglu, Richard E. Heinz, David W. Freeman, Brooke L. Gates, Berhane M. Hagos, Evan Booker, Elnaz Mirzaei Mehrabad, Hyrum T. Diesen, Kishan Bhakta, Supraja Ranganathan, Masami Kachi, Mathias Leblanc, Peter C. Gray, Benjamin T. Spike
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-14 (2020)
Abstract Background CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia
Externí odkaz:
https://doaj.org/article/c3087deb5d704acbbb79917f2e2e47ce
Autor:
Xuanmao Jiao, Zhiping Li, Min Wang, Sanjay Katiyar, Gabriele Di Sante, Mehdi Farshchian, Andrew P. South, Cinzia Cocola, Daniele Colombo, Rolland Reinbold, Ileana Zucchi, Kongming Wu, Ira Tabas, Benjamin T. Spike, Richard G. Pestell
Publikováno v:
Stem Cell Reports, Vol 12, Iss 1, Pp 135-151 (2019)
Summary: DACH1 abundance is reduced in human malignancies, including breast cancer. Herein DACH1 was detected among multipotent fetal mammary stem cells in the embryo, among mixed lineage precursors, and in adult basal cells and (ERα+) luminal proge
Externí odkaz:
https://doaj.org/article/885214bcef514ddbb8d18f7c16c23f08
Autor:
David W. Freeman, Elisa Rodrigues Sousa, Sofia Karkampouna, Eugenio Zoni, Peter C. Gray, David S. Salomon, Marianna Kruithof-de Julio, Benjamin T. Spike
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10164 (2021)
There exists a set of factors termed oncofetal proteins that play key roles in ontogeny before they decline or disappear as the organism’s tissues achieve homeostasis, only to then re-emerge in cancer. Although the unique therapeutic potential pres
Externí odkaz:
https://doaj.org/article/ad61ced48a4149ea8eec2eec8b96a271
Publikováno v:
npj Breast Cancer, Vol 3, Iss 1, Pp 1-11 (2017)
Stem cells: protein not needed for stem cell activity in mammary gland A protein considered necessary for mammary stem cell activity turns out to be dispensable. What’s more, it’s not required for tumor development either. Geoffrey Wahl, Christy
Externí odkaz:
https://doaj.org/article/783e12b271884b9b9b78b908f152ebbb
Autor:
Geoffrey M. Wahl, Benjamin T. Spike
Publikováno v:
npj Breast Cancer, Vol 3, Iss 1, Pp 1-13 (2017)
Abstract Cellular heterogeneity in cancer represents a significant challenge. In order to develop effective and lasting therapies, it is essential to understand the source of this heterogeneity, and its role in tumor progression and therapy resistanc
Externí odkaz:
https://doaj.org/article/657a1343dbc640d09e0f4e77d11190cc
Autor:
Rajshekhar R. Giraddi, Chi-Yeh Chung, Richard E. Heinz, Ozlen Balcioglu, Mark Novotny, Christy L. Trejo, Christopher Dravis, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, Luo Wei Rodewald, Jae Y. Hwang, Cheng Fan, Roger Lasken, Katherine E. Varley, Charles M. Perou, Geoffrey M. Wahl, Benjamin T. Spike
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
Summary: The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We ad
Externí odkaz:
https://doaj.org/article/38eeb434d83440d7b7cd474042626a72
Autor:
Christopher Dravis, Benjamin T. Spike, J. Chuck Harrell, Claire Johns, Christy L. Trejo, E. Michelle Southard-Smith, Charles M. Perou, Geoffrey M. Wahl
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 2035-2048 (2015)
To discover mechanisms that mediate plasticity in mammary cells, we characterized signaling networks that are present in the mammary stem cells responsible for fetal and adult mammary development. These analyses identified a signaling axis between FG
Externí odkaz:
https://doaj.org/article/efcb6cbde9454d92a40e80856ddaf3d3