Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Benjamin T. Circello"'
Autor:
William W. Metcalf, Benjamin T. Circello, Jun Kai Zhang, Xiaomin Yu, Sarath Chandra Janga, James R. Doroghazi, Benjamin M. Griffin, David P. Labeda
Publikováno v:
Proceedings of the National Academy of Sciences. 110:20759-20764
Phosphonates, molecules containing direct carbon-phosphorus bonds, compose a structurally diverse class of natural products with interesting and useful biological properties. Although their synthesis in protozoa was discovered more than 50 y ago, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881dedeadbd27d95959e774f7d0f6cfe
https://doi.org/10.1073/pnas.1315107110
https://doi.org/10.1073/pnas.1315107110
Autor:
Wilfred A. van der Donk, Benjamin T. Circello, William W. Metcalf, Andrew C. Eliot, Jin Hee Lee
Publikováno v:
Chemistry & Biology. 17(4):402-411
Dehydrophos is a vinyl phosphonate tripeptide produced by Streptomyces luridus with demonstrated broad spectrum antibiotic activity. To identify genes necessary for biosynthesis of this unusual compound we screened a fosmid library of S. luridus for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7614afe1223068b35ec411fa6112c0
Autor:
Benjamin T. Circello, Joshua A. V. Blodgett, Wilfred A. van der Donk, Andrew C. Eliot, Zengyi Shao, Gongyong Li, Huimin Zhao, Ryan Woodyer, William W. Metcalf
Publikováno v:
Journal of Biological Chemistry. 283:23161-23168
Phosphonic acids encompass a common yet chemically diverse class of natural products that often possess potent biological activities. Here we report that, despite the significant structural differences among many of these compounds, their biosyntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e11d624bf699db90affea9eff3ad7e
https://doi.org/10.1074/jbc.m801788200
https://doi.org/10.1074/jbc.m801788200
Autor:
Wilfred A. van der Donk, Benjamin T. Circello, Jin Hee Lee, Charles G. Miller, William W. Metcalf
Publikováno v:
Antimicrobial agents and chemotherapy. 55(7)
The metabolic processing of dehydrophos, a broad-spectrum peptide antibiotic containing an unusual vinyl-phosphonate moiety, was examined by using a panel of Salmonella enterica mutants deficient in peptide uptake and catabolism. Dehydrophos bioactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f86b9459c936175a8d36bfef3f9abb
https://pubmed.ncbi.nlm.nih.gov/21537024
https://pubmed.ncbi.nlm.nih.gov/21537024
Autor:
Benjamin T. Circello, Wilfred A. van der Donk, Jin Hee Lee, William W. Metcalf, Brian Bae, Michael Kuemin, Satish K. Nair
Phosphonate natural products possess a range of biological activities as a consequence of their ability to mimic phosphate esters or tetrahedral intermediates formed in enzymatic reactions involved in carboxyl group metabolism. The dianionic form of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f13ce559b4b7ae4294afa308c7bdacf
https://europepmc.org/articles/PMC2955109/
https://europepmc.org/articles/PMC2955109/
Autor:
William W. Metcalf, Wilfred A. van der Donk, Jun Kai Zhang, Benjamin T. Circello, Svetlana A. Borisova
Publikováno v:
Chemistry & Biology. (1):28-37
SummaryRhizocticins are phosphonate oligopeptide antibiotics containing the C-terminal nonproteinogenic amino acid (Z)-l-2-amino-5-phosphono-3-pentenoic acid (APPA). Here we report the identification and characterization of the rhizocticin biosynthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36705db69918f70d5f8bae8ee5c6b1f2