Výsledky vyhledávání - "Benjamin T K Yuen"

Akademický článek

Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism.

Autor: John K Meissen, Benjamin T K Yuen, Tobias Kind, John W Riggs, Dinesh K Barupal, Paul S Knoepfler, Oliver Fiehn

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46770 (2012)

Induced pluripotent stem cells are different from embryonic stem cells as shown by epigenetic and genomics analyses. Depending on cell types and culture conditions, such genetic alterations can lead to different metabolic phenotypes which may impact

Externí odkaz: https://doaj.org/article/dfa564c47dfb414391e572ea7f5cf4a1

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Behavior of Xeno-Transplanted Undifferentiated Human Induced Pluripotent Stem Cells Is Impacted by Microenvironment Without Evidence of Tumors

Autor: Paul S. Knoepfler, Craig Steward, Benjamin T. K. Yuen, Catherine T. Le, Jeanelle Ariza, Kayla Horton-Sparks, Ashley McDonough, Priyanka Somanath, Verónica Martínez-Cerdeño, Bonnie L. Barrilleaux

Publikováno v: Stem cells and development. 26(19)

Human pluripotent stem cells (hPSC) have great clinical potential through the use of their differentiated progeny, a population in which there is some concern over risks of tumorigenicity or other unwanted cellular behavior due to residual hPSC. Prec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89fc89ce53930bf9f698b1fac1f26027
https://pubmed.ncbi.nlm.nih.gov/28693365

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Histone H3.3 regulates dynamic chromatin states during spermatogenesis

Autor: Rebecca Cotterman, Bonnie L. Barrilleaux, Paul S. Knoepfler, Kelly M. Bush, Benjamin T. K. Yuen

Publikováno v: Development. 141:3483-3494

The histone variant H3.3 is involved in diverse biological processes, including development, transcriptional memory and transcriptional reprogramming, as well as diseases, including most notably malignant brain tumors. Recently, we developed a knocko

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73ffa05e6025ae3672e1992932b0e0e
https://doi.org/10.1242/dev.106450

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Histone H3.3 Mutations: A Variant Path to Cancer

Autor: Paul S. Knoepfler, Benjamin T. K. Yuen

Publikováno v: Cancer cell, vol 24, iss 5

A host of cancer types exhibit aberrant histone modifications. Recently, distinct and recurrent mutations in a specific histone variant, histone H3.3, have been implicated in a high proportion of malignant pediatric brain cancers. The presence of mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605e7f8733c1e39db7c7acb2606a220d
https://doi.org/10.1016/j.ccr.2013.09.015

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Mice expressing T4826I‐RYR1 are viable but exhibit sex‐ and genotype‐dependent susceptibility to malignant hyperthermia and muscle damage

Autor: Wei Feng, Feliciano Protasi, Paul D. Allen, Isaac N. Pessah, Simona Boncompagni, Samuel R. Goth, Klaus I. Matthaei, Jose R. Lopez, Benjamin T. K. Yuen, Tianzhong Yang, Clara Franzini-Armstrong

Publikováno v: The FASEB Journal. 26:1311-1322

Mutation T4825I in the type 1 ryanodine receptor (RYR1T4825I/+) confers human malignant hyperthermia susceptibility (MHS). We report a knock-in mouse line that expresses the isogenetic mutation T4826I. Heterozygous RYR1T4826I/+ (Het) or homozygous RY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdaea4647a04f4c07354e22e78e1000
https://doi.org/10.1096/fj.11-197582

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Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development

Autor: John W. Riggs, Bonnie L. Barrilleaux, Benjamin T. K. Yuen, Rebecca Cotterman, Henriette O'Geen, Kelly M. Bush, Paul S. Knoepfler

Publikováno v: Bush, Kelly M; Yuen, Benjamin TK; Barrilleaux, Bonnie L; Riggs, John W; O’Geen, Henriette; Cotterman, Rebecca F; et al.(2013). Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Epigenetics & Chromatin, 6(1), 7. doi: http://dx.doi.org/10.1186/1756-8935-6-7. Retrieved from: http://www.escholarship.org/uc/item/4c96g6pw
Epigenetics & Chromatin

Background The histone variant H3.3 plays key roles in regulating chromatin states and transcription. However, the role of endogenous H3.3 in mammalian cells and during development has been less thoroughly investigated. To address this gap, we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e771a9ac0487438db7c8782cffa3c17c
http://www.escholarship.org/uc/item/4c96g6pw

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Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism

Autor: Tobias Kind, Oliver Fiehn, Dinesh Kumar Barupal, Paul S. Knoepfler, Benjamin T. K. Yuen, John W. Riggs, John K. Meissen

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e46770 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d09a767787db78579511a087b60294c
https://pubmed.ncbi.nlm.nih.gov/23077522

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