Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Benjamin Strobel"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101280- (2024)
Adeno-associated virus (AAV) vectors have become the leading platform for gene delivery in both preclinical research and therapeutic applications, making the production of high-titer AAV preparations essential. To date, most AAV-based studies use con
Externí odkaz:
https://doaj.org/article/f2f2f5ab3b8049c899dee3e3ac4bce71
Autor:
Matthias J. Düchs, Ramona F. Kratzer, Pablo Vieyra-Garcia, Benjamin Strobel, Tanja Schönberger, Peter Groß, Ghaith Aljayyoussi, Aradhana Gupta, Isabel Lang, Holger Klein, Sandra Martinez Morilla, Stefan Hopf, John Park, Sebastian Kreuz, Matthias Klugmann, Frederik H. Igney
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Hepatocellular carcinoma (HCC) and solid cancers with liver metastases are indications with high unmet medical need. Interleukin-12 (IL-12) is a proinflammatory cytokine with substantial anti-tumor properties, but its therapeutic potential has not be
Externí odkaz:
https://doaj.org/article/d7f68968ee5443eba85a103c30a0af1e
Autor:
Dalia Pakalniškytė, Tanja Schönberger, Benjamin Strobel, Birgit Stierstorfer, Thorsten Lamla, Michael Schuler, Martin Lenter
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Transgenic animals with increased or abrogated target gene expression are powerful tools for drug discovery research. Here, we developed a CRISPR-based Rosa26-LSL-dCas9-VPR mouse model for targeted induction of endogenous gene expression usi
Externí odkaz:
https://doaj.org/article/5f71560143154c38951bffbfbcaeeb5e
Autor:
Benjamin Strobel, Holger Klein, Germán Leparc, Birgit E. Stierstorfer, Florian Gantner, Sebastian Kreuz
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract We have previously established a novel mouse model of lung fibrosis based on Adeno-associated virus (AAV)-mediated pulmonary overexpression of TGFβ1. Here, we provide an in-depth characterization of phenotypic and transcriptomic changes (mR
Externí odkaz:
https://doaj.org/article/ca6fe899ada54d63a14b2d469d1d06a1
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 360-369 (2022)
Adeno-associated virus (AAV) vector applications are often limited by capsid-directed humoral immune responses, mainly through neutralizing antibodies (NAbs), which are present throughout the human population due to natural AAV infections. Currently,
Externí odkaz:
https://doaj.org/article/80c63c35850c401f9f6c93aa55504ed4
Autor:
Elke K. Markert, Holger Klein, Coralie Viollet, Werner Rust, Benjamin Strobel, Stefan G. Kauschke, Bar Makovoz, Heike Neubauer, Remko A. Bakker, Timothy A. Blenkinsop
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The therapeutic potential of pluripotent stem cells is great as they promise to usher in a new era of medicine where cells or organs may be prescribed to replace dysfunctional tissue. At the forefront are efforts in the eye to develop this technology
Externí odkaz:
https://doaj.org/article/3592200c6f66475a8e25a8522e509137
Autor:
Benjamin Strobel, Maike Spöring, Holger Klein, Dragica Blazevic, Werner Rust, Sergi Sayols, Jörg S. Hartig, Sebastian Kreuz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Riboswitches can mediate ligand-dependent RNA cleavage and splicing to control gene expression. Here the authors present a method to functionally screen large libraries and identify functional variants.
Externí odkaz:
https://doaj.org/article/490841ff4d214574955fa93d388d9d36
Autor:
Jamie L. Todd, Megan L. Neely, Robert Overton, Katey Durham, Mridu Gulati, Howard Huang, Jesse Roman, L. Kristin Newby, Kevin R. Flaherty, Richard Vinisko, Yi Liu, Janine Roy, Ramona Schmid, Benjamin Strobel, Christian Hesslinger, Thomas B. Leonard, Imre Noth, John A. Belperio, Scott M. Palmer, on behalf of the IPF-PRO Registry investigators
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which diagnosis and management remain challenging. Defining the circulating proteome in IPF may identify targets for biomarker development. We sought to quantif
Externí odkaz:
https://doaj.org/article/e7e9aa1e37874cbe8ab7871c8f6fedf1
Autor:
Verena Aumiller, Benjamin Strobel, Merrit Romeike, Michael Schuler, Birgit E. Stierstorfer, Sebastian Kreuz
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Extracellular matrix (ECM) composition and stiffness are major driving forces for the development and persistence of fibrotic diseases. Lysyl oxidase (LOX) and LOX-like (LOXL) proteins play crucial roles in ECM remodeling due to their collag
Externí odkaz:
https://doaj.org/article/f49ed3e8609443a9a3c9383cebe1ceb5
Publikováno v:
Journal of Eye Movement Research, Vol 9, Iss 4 (2016)
Research on graph comprehension suggests that point differences are easier to read in bar graphs, while trends are easier to read in line graphs. But are graph readers able to detect and use the most suited graph type for a given task? In this study,
Externí odkaz:
https://doaj.org/article/ee1334e8f74d4455b30cb26466f5ca76