Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Benjamin Speich"'
Autor:
Hualin Lüthi, Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, Tanja Vukajlovic, Katja Bologna, Michelle Steinmetz, Cemile Bathelt, Clara O. Sailer, Mirjam Laager, Deborah R. Vogt, Lars G. Hemkens, Benjamin Speich, Sandrine A. Urwyler, Jill Kühne, Fabienne Baur, Linda N. Lutz, Tobias E. Erlanger, Mirjam Christ-Crain, Bettina Winzeler
Publikováno v:
EClinicalMedicine, Vol 68, Iss , Pp 102429- (2024)
Summary: Background: Smoking cessation is challenging, despite making use of established smoking cessation therapies. Preclinical studies and one clinical pilot study suggest the antidiabetic drug glucagon-like peptide-1 (GLP-1) analogue to modulate
Externí odkaz:
https://doaj.org/article/8c47a01a7b914ca09c486ee55de1736c
Autor:
Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, David Coynel, Deborah R. Vogt, Lars G. Hemkens, Benjamin Speich, Davide Zanchi, Tobias E. Erlanger, Mirjam Christ-Crain, Bettina Winzeler
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Cigarette smoking is the leading preventable cause of premature death. Despite dedicated programmes, quit rates remain low due to barriers such as nicotine withdrawal syndrome or post-cessation weight gain. Glucagon-like peptide-1
Externí odkaz:
https://doaj.org/article/44510571840b4e0ba0925baafd2209e3
Autor:
Benjamin Speich, Ayodele Odutayo, Nicholas Peckham, Alexander Ooms, Jamie R. Stokes, Ramon Saccilotto, Dmitry Gryaznov, Belinda von Niederhäusern, Bethan Copsey, Douglas G. Altman, Matthias Briel, Sally Hopewell
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background To assess the quality of reporting of RCT protocols approved by UK research ethics committees before and after the publication of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline. Methods W
Externí odkaz:
https://doaj.org/article/8a043167f2c14e0c91b35bc1c75c4066
Autor:
Katharina Kusejko, Frédérique Chammartin, Daniel Smith, Marc Odermatt, Julian Schuhmacher, Michael Koller, Huldrych F. Günthard, Matthias Briel, Heiner C. Bucher, Benjamin Speich, the Swiss HIV Cohort Study, Swiss Transplant Cohort Study
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background The rapid course of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic calls for fast implementation of clinical trials to assess the effects of new treatment and prophylactic interventions. Building trial p
Externí odkaz:
https://doaj.org/article/b14544aa5d38461fb07ac869e78556e1
Autor:
Paula Dhiman, Jie Ma, Constanza L. Andaur Navarro, Benjamin Speich, Garrett Bullock, Johanna A. A. Damen, Lotty Hooft, Shona Kirtley, Richard D. Riley, Ben Van Calster, Karel G. M. Moons, Gary S. Collins
Publikováno v:
Diagnostic and Prognostic Research, Vol 6, Iss 1, Pp 1-14 (2022)
Abstract Background Prognostic models are used widely in the oncology domain to guide medical decision-making. Little is known about the risk of bias of prognostic models developed using machine learning and the barriers to their clinical uptake in t
Externí odkaz:
https://doaj.org/article/7ee68c8c770a4944a9c8881337a9a407
Autor:
Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, Tanja Vukajlovic, Katja Bologna, Michelle Steinmetz, Cemile Bathelt, Clara O. Sailer, Deborah R. Vogt, Lars G. Hemkens, Benjamin Speich, Sandrine A. Urwyler, Jill Kühne, Fabienne Baur, Linda N. Lutz, Tobias E. Erlanger, Mirjam Christ-Crain, Bettina Winzeler
Publikováno v:
EClinicalMedicine, Vol 57, Iss , Pp 101865- (2023)
Summary: Background: Quitting smoking is difficult due to barriers such as craving for cigarettes and post-cessation weight gain. Recent experimental data suggest a role of glucagon-like peptide-1 (GLP-1) in the pathophysiology of addiction in additi
Externí odkaz:
https://doaj.org/article/c443ef879b124d26a98b5b12aa51d92a
Autor:
Viktoria Gloy, Benjamin Speich, Alexandra Griessbach, Ala Taji Heravi, Alexandra Schulz, Thomas Fabbro, Christiane Pauli Magnus, Stuart McLennan, Wendy Bertram, Matthias Briel
Publikováno v:
BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Background Whether there is sufficient capacity and capability for the successful conduct and delivery of a clinical trial should be assessed by several stakeholders according to transparent and evidence-based criteria during trial planning.
Externí odkaz:
https://doaj.org/article/1e150614f34546439122a6764c5aa7e1
Autor:
Paula Dhiman, Jie Ma, Constanza L. Andaur Navarro, Benjamin Speich, Garrett Bullock, Johanna A. A. Damen, Lotty Hooft, Shona Kirtley, Richard D. Riley, Ben Van Calster, Karel G. M. Moons, Gary S. Collins
Publikováno v:
BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-16 (2022)
Abstract Background Describe and evaluate the methodological conduct of prognostic prediction models developed using machine learning methods in oncology. Methods We conducted a systematic review in MEDLINE and Embase between 01/01/2019 and 05/09/201
Externí odkaz:
https://doaj.org/article/a5e2429153c94a088342a9d1239c1e39
Autor:
Benjamin Speich, Frédérique Chammartin, Daniel Smith, Marcel P. Stoeckle, Patrizia Amico, Anna L. Eichenberger, Barbara Hasse, Macé M. Schuurmans, Thomas Müller, Michael Tamm, Michael Dickenmann, Irene A. Abela, Alexandra Trkola, Hans H. Hirsch, Oriol Manuel, Matthias Cavassini, Lars G. Hemkens, Matthias Briel, Nicolas J. Mueller, Andri Rauch, Huldrych F. Günthard, Michael T. Koller, Heiner C. Bucher, Katharina Kusejko, in collaboration with the study groups from the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Late 2019, a new highly contagious coronavirus SARS-CoV-2 has emerged in Wuhan, China, causing within 2 months a pandemic with the highest disease burden in elderly and people with pre-existing medical conditions. The pandemic has
Externí odkaz:
https://doaj.org/article/2128b74ef7444eeeafbfd6921999843a
Autor:
Piero L Olliaro, Michel T Vaillant, Aïssatou Diawara, Benjamin Speich, Marco Albonico, Jürg Utzinger, Jennifer Keiser
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010593 (2022)
BackgroundPeriodic administration of anthelmintic drugs is a cost-effective intervention for morbidity control of soil-transmitted helminth (STH) infections. However, with programs expanding, drug pressure potentially selecting for drug-resistant par
Externí odkaz:
https://doaj.org/article/5b1563a9a0d04c94b28795a04a7a6f83