Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir

Autor: Marieke Gringmuth, Jenny Walther, Sebastian Greiser, Magali Toussaint, Benjamin Schwalm, Marcel Kool, Rolf-Dieter Kortmann, Annegret Glasow, Ina Patties

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 7, p 3815 (2022)

Children with high-risk SHH/TP53-mut and Group 3 medulloblastoma (MB) have a 5-year overall survival of only 40%. Innovative approaches to enhance survival while preventing adverse effects are urgently needed. We investigated an innovative therapy ap

Externí odkaz: https://doaj.org/article/5af009a681794e13ac66563d68719e96

EPCO-47. ITCC-P4: GENOMIC PROFILING AND ANALYSES OF PEDIATRIC PATIENT TUMOR AND PATIENT-DERIVED XENOGRAFT (PDX) MODELS FOR HIGH THROUGHPUT IN VIVO TESTING

Autor: Apurva Gopisetty, Aniello Federico, Didier Surdez, Elnaz Saberi-Ansari, Yasmine Iddir, Alexandra Saint-Charles, Joshua Waterfall, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, David T Jones, Johannes Gojo, Louis Chesler, Gilles Vassal, Lou Stancato, Jan Koster, Jan J Molenaar, Natalie Jaeger, Gudrun Schleiermacher, Stefan Pfister, Marcel Kool

Publikováno v: Neuro-Oncology. 24:vii126-vii127

Advancements in state-of-the-art molecular profiling techniques has resulted in better understanding of pediatric cancers and their drivers. Conversely, it also became apparent that pediatric cancers are much more heterogeneous than previously though

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c43a31fe055855349266fd37f77f0de
https://doi.org/10.1093/neuonc/noac209.481

MODL-01. Targeting replication stress in pediatric brain tumors

Autor: Sonja Krausert, Norman Mack, Benjamin Schwalm, Heike Peterziel, Ina Oehme, Cornelis M van Tilburg, Olaf Witt, Stefan M Pfister, Marcel Kool

Publikováno v: Neuro-Oncology. 24:i168-i168

Previously, we have found that Embryonal Tumors with Multilayered Rosettes (ETMR) tumor cells harboring high levels of R-loops, a potential marker for replication stress and genomic instability, are vulnerable to a combination of topoisomerase and PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a47eee29ef11496958c015b1ab8010e
https://doi.org/10.1093/neuonc/noac079.624

MEDB-52. Organoids as preclinical models to improve and personalize disease outcome for sonic hedgehog medulloblastoma

Autor: Zelda Odé, Joris Maas, Mieke Roosen, Phylicia Stathi, Aniello Federico, Norman Mack, Benjamin Schwalm, Jens Bunt, Marcel Kool

Publikováno v: Neuro-Oncology. 24:i118-i118

Four main medulloblastoma (MB) molecular subgroups are known, including the sonic hedgehog (SHH) subgroup, which represents ~25% of MB cases. The 5-year overall survival of SHH-MB is ~80%. However, survival between patients is highly diverse and depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f523bc96a7a27bb2da2dbec0b850a288
https://doi.org/10.1093/neuonc/noac079.426

The molecular landscape of ETMR at diagnosis and relapse

Autor: Olaf Witt, Maria Łastowska, Anna Darabi, Ulrich Schüller, Andreas von Deimling, Nada Jabado, Susanne Gröbner, David Sumerauer, Annie Huang, Sebastian M. Waszak, Martin Sill, Xiao-Nan Li, Andrey Korshunov, Julien Masliah-Planchon, Pablo Landgraf, David Ellison, Maria J. Gil-da-Costa, Alexander J.R. Bishop, Christin Schmidt, Pieter Wesseling, Sebastian Brabetz, Marc Remke, July Carolina Romero, Dominique Figarella-Branger, Peter Hauser, Simon Papillon-Cavanagh, Jennifer A. Chan, Felix Sahm, Benjamin Schwalm, Peter Lichter, Ivo Buchhalter, Stephan Wolf, Norman Mack, Matthias A. Karajannis, Till Milde, Jan Koster, Valérie Rigau, Monika Mauermann, Matija Snuderl, Franck Bourdeaut, Christine Haberler, Torsten Pietsch, Volker Hovestadt, Wiesława Grajkowska, Katja von Hoff, Felice Giangaspero, Marcel Kool, Emmanuelle Uro-Coste, Jan O. Korbel, Michael D. Taylor, Martin Hasselblatt, Tobias Rausch, Danny A. Zwijnenburg, Jonas Ecker, Brent A. Orr, David T.W. Jones, Jens Schittenhelm, Aparna Gorthi, Sonja Krausert, Sanda Alexandrescu, Sander Lambo, Jens Martin Hübner, Ben Ho, Stefan M. Pfister, Marina Ryzhova

Publikováno v: Nature
Nature, Nature Publishing Group, 2019, 576 (7786), pp.274-280. ⟨10.1038/s41586-019-1815-x⟩
Nature, 576(7786), 274-280. Nature Publishing Group
Lambo, S, Gröbner, S N, Rausch, T, Waszak, S M, Schmidt, C, Gorthi, A, Romero, J C, Mauermann, M, Brabetz, S, Krausert, S, Buchhalter, I, Koster, J, Zwijnenburg, D A, Sill, M, Hübner, J-M, Mack, N, Schwalm, B, Ryzhova, M, Hovestadt, V, Papillon-Cavanagh, S, Chan, J A, Landgraf, P, Ho, B, Milde, T, Witt, O, Ecker, J, Sahm, F, Sumerauer, D, Ellison, D W, Orr, B A, Darabi, A, Haberler, C, Figarella-Branger, D, Wesseling, P, Schittenhelm, J, Remke, M, Taylor, M D, Gil-da-Costa, M J, Łastowska, M, Grajkowska, W, Hasselblatt, M, Hauser, P, Pietsch, T, Uro-Coste, E, Bourdeaut, F, Masliah-Planchon, J, Rigau, V, Alexandrescu, S, Wolf, S, Li, X-N, Schüller, U, Snuderl, M, Karajannis, M A, Giangaspero, F, Jabado, N, von Deimling, A, Jones, D T W, Korbel, J O, von Hoff, K, Lichter, P, Huang, A, Bishop, A J R, Pfister, S M, Korshunov, A & Kool, M 2019, ' The molecular landscape of ETMR at diagnosis and relapse ', Nature, vol. 576, no. 7786, pp. 274-280 . https://doi.org/10.1038/s41586-019-1815-x
Nature, 2019, 576 (7786), pp.274-280. ⟨10.1038/s41586-019-1815-x⟩

Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally poor prognosis1. Here we collected 193 primary ETMRs and 23 matched relapse samples to investigate the genomic landscape of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a9fb34e854ed244d44bc4f785f2b10
https://hal.archives-ouvertes.fr/hal-02441051