Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Benjamin Schuster-Böckler"'
Autor:
Weiqi Liao, Carol A.C. Coupland, Hamish Innes, Peter Jepsen, Philippa C. Matthews, Cori Campbell, Eleanor Barnes, Julia Hippisley-Cox, Emma Culver, Roman Fischer, William L. Irving, Matt Kelly, Paul Klenerman, Derek Mann, Aileen Marshall, Michael Pavlides, Rory J.R. Peters, Elisabeth Pickles, James Robineau, Benjamin Schuster-Böckler, Chunxiao Song, Jeremy Tomlinson, Christopher Welberry
Publikováno v:
EClinicalMedicine, Vol 59, Iss , Pp 101969- (2023)
Summary: Background: Liver cancer has one of the fastest rising incidence and mortality rates among all cancers in the UK, but it receives little attention. This study aims to understand the disparities in epidemiology and clinical pathways of primar
Externí odkaz:
https://doaj.org/article/ea75e1ea24bf4ca0accc5268368905c7
Autor:
Richard Peter Owen, Michael Joseph White, David Tyler Severson, Barbara Braden, Adam Bailey, Robert Goldin, Lai Mun Wang, Carlos Ruiz-Puig, Nicholas David Maynard, Angie Green, Paolo Piazza, David Buck, Mark Ross Middleton, Chris Paul Ponting, Benjamin Schuster-Böckler, Xin Lu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Barrett’s oesophagus is associated with an increased risk of oseophageal cancer, but its cell of origin is unclear. Here the authors show, using single-cell RNA sequencing of biopsies from six patients and two unaffected subjects, that cells in Bar
Externí odkaz:
https://doaj.org/article/53c87fc54c1542f789eced6b76559b59
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures—each representing a mutagenic process—derived from 305
Externí odkaz:
https://doaj.org/article/925caf3529b54dc28fa35d57ce2370bb
Autor:
Daniel Temko, Ian P. M. Tomlinson, Simone Severini, Benjamin Schuster-Böckler, Trevor A. Graham
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
A central question in cancer research is how specific driver mutations are acquired and maintained during cancer development. Here Temko et al. use public sequencing data to infer the effect of mutation and selection on a set of driver mutations and
Externí odkaz:
https://doaj.org/article/2f20429856604bb1a50d0d6d22d58faa
Autor:
Daniel Temko, Ian P. M. Tomlinson, Simone Severini, Benjamin Schuster-Böckler, Trevor A. Graham
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/d60941f81d8647c6ae7bb3e674a706fc
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9474 (2010)
Dosage sensitivity is an important evolutionary force which impacts on gene dispensability and duplicability. The newly available data on human copy-number variation (CNV) allow an analysis of the most recent and ongoing evolution. Provided that hete
Externí odkaz:
https://doaj.org/article/6e1c1016104f4ff8855ddbded8c9ae6c
Autor:
Phil F. Xie, Jaeho Chang, Paulina Siejka-Zielińska, Masato Inoue, Magdalena Drożdż, Joseph A. Chadwick, Thomas M. Carroll, Richard P. Owen, Michael J. White, Joseph Kaplinsky, Robert Amess, Mark Middleton, Skirmantas Kriaucionis, Chunxiao Song, Benjamin Schuster-Böckler, Xin Lu
Publikováno v:
Cancer Research. 83:LB131-LB131
Immune checkpoint inhibitors (ICI) were recently approved as a first-line treatment for inoperable esophageal adenocarcinomas (EAC) in combination with chemotherapy (CTX). Unfortunately, even though EAC has one of the highest tumor mutation burdens a
Autor:
Eleanor Barnes, Derek A. Mann, Yibin Liu, Chun-Xiao Song, Emma L. Culver, Paulina Siejka-Zielińska, Shivan Sivakumar, Zahir Soonawalla, Srikanth Reddy, Luminita Puta, Felix O. Jackson, Pier Francesco Palamara, Benjamin Schuster-Böckler, Jingfei Cheng, Noor Bekkali, Michael Silva, Misti Vanette McCain, Helen L. Reeves
Multimodal, genome-wide characterization of epigenetic and genetic information in circulating cell-free DNA (cfDNA) could enable more sensitive early cancer detection, but it is technologically challenging. Recently, we developed TET-assisted pyridin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921f05487fdd1d58c841d5ba438f5423
https://ora.ox.ac.uk/objects/uuid:c13e7e85-0339-471c-9c1b-0f9a85d8870b
https://ora.ox.ac.uk/objects/uuid:c13e7e85-0339-471c-9c1b-0f9a85d8870b
Autor:
Marketa Tomkova, Fang Yuan, Benjamin Schuster-Böckler, P Siejka, Lei Chen, Chun-Xiao Song, Chunsen Bai, Gergana Velikova, Ying Bi, Yibin Liu
Publikováno v:
Nature Biotechnology. 37:424-429
Bisulfite sequencing has been the gold standard for mapping DNA modifications including 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) for decades1–4. However, this harsh chemical treatment degrades the majority of the DNA and generates
Autor:
Thomas M. Carroll, Joseph A. Chadwick, Richard P. Owen, Michael J. White, Joseph Kaplinsky, Iliana Peneva, Anna Frangou, Jaeho Chang, Phil F. Xie, Andrew Roth, Bob Amess, Hantao Lou, Katy J. McCann, Georgina Berridge, Roman Fischer, Chansavath Phetsouphanh, Ayo O. Omiyale, Brittany-Amber Jacobs, David Ahern, Simon R. Lord, Stewart Norris-Bulpitt, Sam T. Dobbie, Lucinda Griffiths, Kristen Aufiero Ramirez, Toni Ricciardi, Mary J. Macri, Aileen Ryan, Ralph R. Venhaus, Benoit J. Van den Eynde, Ioannis Karydis, Benedikt M. Kessler, Benjamin Schuster-Böckler, Mark R. Middleton, Xin Lu
Publikováno v:
Cancer Research. 82:1247-1247
For patients with inoperable esophageal adenocarcinoma (EAC), prognosis on conventional chemotherapy (CTX) remains poor. In 2021, the FDA approved two αPD-1 immune checkpoint inhibitors (ICI) for addition to fluoropyrimidine/platinum-containing CTX