Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Benjamin Schoeps"'
Autor:
Olga Prokopchuk, Chris D. Hermann, Benjamin Schoeps, Ulrich Nitsche, Oleksii L. Prokopchuk, Percy Knolle, Helmut Friess, Marc E. Martignoni, Achim Krüger
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 2, Pp 378-392 (2021)
Abstract Background Cachexia, a devastating syndrome in cancer patients, critically determines survival and life quality. It is characterized by impaired homeostasis of multiple organs including the liver, involves tissue wasting, and is conventional
Externí odkaz:
https://doaj.org/article/a7dc9b645cee470ea5769eeccc0af8ef
Autor:
Achim Krüger, Chris D. Hermann, Dieter E. Jenne, Oliver Soehnlein, Percy Knolle, Ihsan Ekin Demir, Katja Steiger, Daniel Häußler, Jan Böttcher, Olga Prokopchuk, Celina Eckfeld, Benjamin Schoeps
Supplementary Material and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5960aa13a293dcfe330c0fada2d2867f
https://doi.org/10.1158/0008-5472.22428897
https://doi.org/10.1158/0008-5472.22428897
Autor:
Achim Krüger, Chris D. Hermann, Dieter E. Jenne, Oliver Soehnlein, Percy Knolle, Ihsan Ekin Demir, Katja Steiger, Daniel Häußler, Jan Böttcher, Olga Prokopchuk, Celina Eckfeld, Benjamin Schoeps
Supplementary Figures S1 - S9 Table S1 and S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780a73b5875ce4e4ef57b96f3b69499e
https://doi.org/10.1158/0008-5472.22428888.v1
https://doi.org/10.1158/0008-5472.22428888.v1
Autor:
Achim Krüger, Chris D. Hermann, Dieter E. Jenne, Oliver Soehnlein, Percy Knolle, Ihsan Ekin Demir, Katja Steiger, Daniel Häußler, Jan Böttcher, Olga Prokopchuk, Celina Eckfeld, Benjamin Schoeps
Tumor-derived protein tissue inhibitor of metalloproteinases-1 (TIMP1) correlates with poor prognosis in many cancers, including highly lethal pancreatic ductal adenocarcinoma (PDAC). The noncanonical signaling activity of TIMP1 is emerging as one ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae45c252202ed60f7d6bcd78d55c4a7
https://doi.org/10.1158/0008-5472.c.6513189.v1
https://doi.org/10.1158/0008-5472.c.6513189.v1
Autor:
Celina Eckfeld, Benjamin Schoeps, Daniel Häußler, Julian Frädrich, Felix Bayerl, Jan Philipp Böttcher, Percy Knolle, Simone Heisz, Olga Prokopchuk, Hans Hauner, Enkhtsetseg Munkhbaatar, Ihsan Ekin Demir, Chris D. Hermann, Achim Krüger
Publikováno v:
Journal of Cell Biology. 222
The emerging cytokine tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with the progression of inflammatory diseases, including cancer. However, the effects of TIMP-1 on immune cell activation and underlying molecular mechanisms are large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0241f3c3a9a606dccd2df60fb54f9629
https://doi.org/10.1083/jcb.202206095
https://doi.org/10.1083/jcb.202206095
Publikováno v:
Trends in cell biology.
Appreciation of the entire biological impact of an individual protein can be hampered by its original naming based on one function only. Tissue inhibitor of metalloproteinases-1 (TIMP-1), mostly known for its eponymous function to inhibit metalloprot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2b2c0be114b1ed6449de098c11f97e
https://pubmed.ncbi.nlm.nih.gov/36163148
https://pubmed.ncbi.nlm.nih.gov/36163148
Autor:
Percy A. Knolle, Olga Prokopchuk, Achim Krüger, Chris D. Hermann, Jan P. Böttcher, Celina Eckfeld, Ihsan Ekin Demir, Dieter E. Jenne, Daniel Häußler, Oliver Soehnlein, Benjamin Schoeps, Katja Steiger
Publikováno v:
Cancer Res. 81, 3568-3579 (2021)
Tumor-derived protein tissue inhibitor of metalloproteinases-1 (TIMP1) correlates with poor prognosis in many cancers, including highly lethal pancreatic ductal adenocarcinoma (PDAC). The noncanonical signaling activity of TIMP1 is emerging as one ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df9c070cc4675dbf50335deea7a29eb
https://doi.org/10.1158/0008-5472.can-20-4125
https://doi.org/10.1158/0008-5472.can-20-4125
Autor:
Chris D. Hermann, Katja Steiger, Emily Poulton, Enkhtsetseg Munkhbaatar, Rama Khokha, Ihsan Ekin Demir, Lukas Kniep, Benjamin Schoeps, Achim Krüger, Celina Eckfeld, Olga Prokopchuk, Daniel Häußler, N. Wirges, Percy A. Knolle, Barbara Grünwald
Publikováno v:
Journal of Experimental Medicine. 218
Sex disparity in cancer is so far inadequately considered, and components of its basis are rather unknown. We reveal that male versus female pancreatic cancer (PC) patients and mice show shortened survival, more frequent liver metastasis, and elevate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a82791ecf25f4e7ac334ff7f926756
https://doi.org/10.1084/jem.20210911
https://doi.org/10.1084/jem.20210911
Publikováno v:
Cancer and Metastasis Reviews. 38:469-481
The members of the tissue inhibitor of metalloproteinase (TIMP) family (TIMP-1, 2, 3, 4) are prominently appreciated as natural inhibitors of cancer-promoting metalloproteinases. However, clinical and recent functional studies indicate that some of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381fe78fa22670b83f85bd1c41cf27ff
https://doi.org/10.1007/s10555-019-09812-6
https://doi.org/10.1007/s10555-019-09812-6
Autor:
Zhiheng Zhang, Jörg Kleeff, Nadja Maeritz, Susanne Raulefs, Xiaoping Zou, Helmut Friess, Christina Ludwig, Dianbo Yao, Kathleen Schuck, Metello Innocenti, Yamin Zhao, Shanshan Shen, Vivien Tissen, Achim Krüger, Christoph W. Michalski, Jan G. D’Haese, Rob A. van der Kammen, Carsten Jäger, Benjamin Schoeps, Anna Melissa Schlitter, Bo Kong
Background & Aims Oncogenic KrasG12D induces neoplastic transformation of pancreatic acinar cells through acinar-to-ductal metaplasia (ADM), an actin-based morphogenetic process, and drives pancreatic ductal adenocarcinoma (PDAC). mTOR (mechanistic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba34c09707c2496b2d8d168be927eda2
https://hdl.handle.net/10281/396252
https://hdl.handle.net/10281/396252