Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Benjamin S. Schuster"'
Publikováno v:
Biophysical Reports, Vol 1, Iss 1, Pp 100011- (2021)
The material properties of biomolecular condensates have been suggested to play important biological and pathological roles. Despite the rapid increase in the number of biomolecules identified that undergo liquid-liquid phase separation, quantitative
Externí odkaz:
https://doaj.org/article/a076e776bd6741e5aeea5e4638ea6a87
Autor:
Benjamin S. Schuster, Ellen H. Reed, Ranganath Parthasarathy, Craig N. Jahnke, Reese M. Caldwell, Jessica G. Bermudez, Holly Ramage, Matthew C. Good, Daniel A. Hammer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Designer organelles with new biochemical functionalities are of great interest in synthetic biology and cellular engineering. Here the authors present a single-protein-based platform for generating synthetic membraneless compartments that is capable
Externí odkaz:
https://doaj.org/article/66e8162a85c44e12a7eb131604d160da
Autor:
Shiv Rekhi, Cristobal Garcia Garcia, Mayur Barai, Azamat Rizuan, Benjamin S. Schuster, Kristi L. Kiick, Jeetain Mittal
Understanding the relationship between an amino acid sequence and its phase separation has important implications for analyzing cellular function, treating disease, and designing novel biomaterials. Several sequence features have been identified as d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07f2208802fcb9917e99da36a7f63a4e
https://doi.org/10.1101/2023.03.02.530853
https://doi.org/10.1101/2023.03.02.530853
Autor:
Matthew C. Good, Daniel A. Hammer, Benjamin S. Schuster, Marcel Leutenegger, Muyang Guan, Mikael V Garabedian
Publikováno v:
Biochemistry. 60:3137-3151
Eukaryotic cells partition enzymes and other cellular components into distinct subcellular compartments to generate specialized biochemical niches. A subclass of these compartments form in the absence of lipid membranes, via liquid-liquid phase separ
Autor:
Reese M. Caldwell, Jorge B. Dabdoub, Alexander Deiters, Mikael V Garabedian, Benjamin S. Schuster, Wentao Wang, Michelle Tong, William Benman, Matthew C. Good
Publikováno v:
Nature chemical biology
Subcellular compartmentalization of macromolecules increases flux and prevents inhibitory interactions to control biochemical reactions. Inspired by this functionality, we sought to build designer compartments that function as hubs to regulate the fl
Autor:
Shiv Rekhi, Cristobal Garcia, Mayur Barai, Azamat Rizuan, Benjamin S. Schuster, Kristi Kiick, Jeetain Mittal
Publikováno v:
Biophysical Journal. 122:206a
Publikováno v:
Proc Natl Acad Sci U S A
Cells contain membraneless compartments that assemble due to liquid-liquid phase separation, including biomolecular condensates with complex morphologies. For instance, certain condensates are surrounded by a film of distinct composition, such as Ape
Autor:
Muyang, Guan, Mikael V, Garabedian, Marcel, Leutenegger, Benjamin S, Schuster, Matthew C, Good, Daniel A, Hammer
Publikováno v:
Biochemistry
Eukaryotic cells partition enzymes and other cellular components into distinct subcellular compartments to generate specialized biochemical niches. A subclass of these compartments form in the absence of lipid membranes, via liquid-liquid phase separ
The material properties of biomolecular condensates play pivotal roles in many biological and pathological processes. Despite the rapid increase in the number of biomolecules identified that undergo liquid-liquid phase separation (LLPS), quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d6e7fea7be3773ef3ee1b87e065b662
https://doi.org/10.1101/2021.05.28.446248
https://doi.org/10.1101/2021.05.28.446248
Autor:
Roshan Mammen Regy, Aishwarya Kanchi Ranganath, Zheng Shi, Elliott M Dolan, Sagar D. Khare, Benjamin S. Schuster, Jeetain Mittal, Nina Jovic
Publikováno v:
J Phys Chem B
This perspective article highlights recent progress and emerging challenges in understanding the formation and function of membraneless organelles (MLOs). A long-term goal in the MLO field is to identify the sequence-encoded rules that dictate the fo