Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Benjamin S. Rutledge"'
Autor:
Ahmed Salem, Carter J. Wilson, Benjamin S. Rutledge, Allison Dilliott, Sali Farhan, Wing-Yiu Choy, Martin L. Duennwald
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of both upper and lower motor neurons in the brain and spinal cord. ALS is associated with protein misfolding and inclusion formation involving RNA-
Externí odkaz:
https://doaj.org/article/863c8b1a8e9c4e4fb7ca720b95b26d33
Autor:
Rachel E. Lackie, Aline S. de Miranda, Mei Peng Lim, Vladislav Novikov, Nimrod Madrer, Nadun C. Karunatilleke, Benjamin S. Rutledge, Stephanie Tullo, Anne Brickenden, Matthew E. R. Maitland, David Greenberg, Daniel Gallino, Wen Luo, Anoosha Attaran, Irina Shlaifer, Esther Del Cid Pellitero, Caroline Schild-Poulter, Thomas M. Durcan, Edward A. Fon, Martin Duennwald, Flavio H. Beraldo, M. Mallar Chakravarty, Timothy J. Bussey, Lisa M. Saksida, Hermona Soreq, Wing-Yiu Choy, Vania F. Prado, Marco A. M. Prado
Publikováno v:
Neuroscience Institute Publications
The predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to misfolding and aggregation in synucleinopathies, such as Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). Molecular chaperones play important role
Publikováno v:
The Journal of biological chemistry. 298(5)
The toxic accumulation of misfolded proteins as inclusions, fibrils, or aggregates is a hallmark of many neurodegenerative diseases. However, how molecular chaperones, such as heat shock protein 70 kDa (Hsp70) and heat shock protein 90 kDa (Hsp90), d