Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Benjamin S. Leung"'
Autor:
Benjamin S. Leung
The concept that hormones influence tumor growth originated in 1889 with the proposal of Albert Schinzinger who suggested that breast cancer is related to the ovaries. Several years later, Sir George Beatson observed that remission of disseminated br
Publikováno v:
Journal of Cellular Biochemistry. 59:409-417
Although there is a growing body of evidence that 17β-hydroxysteroid oxidoteductase plays a role the regulation of steroid levels in epithelial tumors of the endometrium and breast, out knowledge of its role in other gynecologic tumors is limited. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294fff634faa59232c76aa9b732c19d1
https://doi.org/10.1002/jcb.240590402
https://doi.org/10.1002/jcb.240590402
Publikováno v:
Journal of Cellular Biochemistry. 46:125-133
To elucidate the relationship between epidermal growth factor (EGF)/transforming growth factor (TGF-alpha) and estradiol-17 beta (E) in cell proliferation, we examined their effects on the breast cancer cell line, CAMA-1. While E was able to consiste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ce2402091075894be1c1d1374cc703
https://doi.org/10.1002/jcb.240460206
https://doi.org/10.1002/jcb.240460206
Autor:
Kamalini Das, George E. Tagatz, Hugh C. Hensleigh, Laurence E. Stout, William R. Phipps, Benjamin S. Leung
Publikováno v:
Fertility and Sterility. 55:1000-1004
Objective Immature mammalian oocytes cultured in vitro undergo inadequate cytoplasmic maturation and hence have a limited potential for fertilization. Our primary objective was to determine if the addition of epidermal growth factor (EGF) to the in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa9739de3d73456ad22db812b20d042
https://doi.org/10.1016/s0015-0282(16)54313-1
https://doi.org/10.1016/s0015-0282(16)54313-1
Publikováno v:
Biochemical and Biophysical Research Communications. 170:569-575
To elucidate the possible roles of proto-oncogenes and growth factors in estrogen-regulated cell proliferation of human breast and gynecologic cancers, we have determined the gene expressions of c-myc, transforming growth factor-alpha and beta 1 (TGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0d98af272cd82b9d09ac0fcd7d262f
https://doi.org/10.1016/0006-291x(90)92129-n
https://doi.org/10.1016/0006-291x(90)92129-n
Publikováno v:
Gynecologic oncology. 85(1)
Objectives. The aim of this study was to determine cervical cancer cell sensitivity to chemotherapy-induced apoptosis based on human papillomavirus (HPV) status. Methods. CaSki (HPV-positive) and C33A (HPV-negative) cells were treated with camptothec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a98d412393140e832599ef83feb851
https://pubmed.ncbi.nlm.nih.gov/11925121
https://pubmed.ncbi.nlm.nih.gov/11925121
Publikováno v:
Biochemical and biophysical research communications. 263(1)
Our objective is to test the hypothesis that inhibition of mitogen-activated protein (MAP) kinase kinase (MEK) with PD98059 in human luteinized granulosa cells will block epidermal growth (EGF)-stimulated MAP kinase activity and induce apoptosis. Lut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaecec9b01a42914bd752386731d383
https://pubmed.ncbi.nlm.nih.gov/10486268
https://pubmed.ncbi.nlm.nih.gov/10486268
Publikováno v:
Fertility and sterility. 71(6)
Objective: To assess the expression of messenger RNA (mRNA) for estrogen receptors α and β in the vaginal walls and uterosacral ligaments of premenopausal and postmenopausal women. Design: In vitro experiment. Setting: Academic research environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fcd08474901918959783b31d6f5987
https://pubmed.ncbi.nlm.nih.gov/10360917
https://pubmed.ncbi.nlm.nih.gov/10360917
Autor:
Benjamin S. Leung, Qingqing Zhang, Helen T. Leung, Hongjun Ji, Ruoping Zhang, Laurence E. Stout
Publikováno v:
Journal of cellular biochemistry. 54(3)
Tamoxifen has been an effective antiestrogen in suppressing breast cancer growth which is estrogen-responsive or dependent. Early studies have provided circumstantial evidence that transforming growth factor-beta (TGF-beta) may be an autocrine mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d798bdf8e8c9298bd4f7b37213cb339
https://pubmed.ncbi.nlm.nih.gov/8200913
https://pubmed.ncbi.nlm.nih.gov/8200913
Autor:
Li Zhou, Benjamin S. Leung
Publikováno v:
Biochimica et biophysica acta. 1180(2)
Regulation of ovarian cancer growth is poorly understood. In this study, the effects of EGF, TGF alpha and TGF beta 1 on two ovarian cancer cell lines (OVCAR-3 and CAOV-3) were investigated. The results showed that EGF/TGF alpha stimulated cell growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c80f9d6b83b44174e98522e07dd5831
https://pubmed.ncbi.nlm.nih.gov/1463764
https://pubmed.ncbi.nlm.nih.gov/1463764