Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Benjamin R. Kingston"'
Autor:
Zachary Pengju Lin, Luan N. M. Nguyen, Ben Ouyang, Presley MacMillan, Jessica Ngai, Benjamin R. Kingston, Stefan M. Mladjenovic, Warren C. W. Chan
Publikováno v:
ACS Nano. 16:6080-6092
Nanoparticles need to navigate a complex microenvironment to target cells in solid tumors after extravasation. Diffusion is currently the accepted primary mechanism for nanoparticle distribution in tumors. However, the extracellular matrix can limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab5849dc59b0627eb3189337a656aff
https://doi.org/10.1021/acsnano.1c11578
https://doi.org/10.1021/acsnano.1c11578
Autor:
Jessica Ngai, Presley MacMillan, Benjamin R. Kingston, Zachary P. Lin, Ben Ouyang, Warren C.W. Chan
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 353
Nanoparticles can reduce cytotoxicity, increase circulation time and increase accumulation in tumours compared to free drug. However, the value of using nanoparticles for carrying small molecules to treat tumours at the cellular level has been poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3cdb9b6e1658c945a8909f72efe92f
https://pubmed.ncbi.nlm.nih.gov/36516899
https://pubmed.ncbi.nlm.nih.gov/36516899
Autor:
Shrey Sindhwani, Zachary P. Lin, Ben Ouyang, Jessica Ngai, Benjamin R. Kingston, Presley MacMillan, Abdullah Muhammad Syed, Warren C. W. Chan
Publikováno v:
ACS Nano. 15:14080-14094
The successful delivery of nanoparticles to solid tumors depends on their ability to pass through blood vessels and into the tumor microenvironment. Here, we discovered a subset of tumor endothelial cells that facilitate nanoparticle transport into s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38d09c859d5c6616457d2e6ff903b7d
https://doi.org/10.1021/acsnano.1c04510
https://doi.org/10.1021/acsnano.1c04510
Autor:
Ben Ouyang, Benjamin R. Kingston, Wilson Poon, Yi-Nan Zhang, Zachary P. Lin, Abdullah M. Syed, Julien Couture-Senécal, Warren C. W. Chan
Publikováno v:
Molecular pharmaceutics. 19(6)
The delivery of therapeutic nanoparticles to target cells is critical to their effectiveness. Here we quantified the impact of biological barriers on the delivery of nanoparticles to macrophages in two different tissues. We compared the delivery of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc1ec0f999dd67e829d38c95d383d74
https://pubmed.ncbi.nlm.nih.gov/35319220
https://pubmed.ncbi.nlm.nih.gov/35319220
Autor:
Anthony J. Tavares, Yi-Nan Zhang, Gang Zheng, Warren C. W. Chan, Julien Couture-Senécal, Juan Chen, Zachary P. Lin, Yuwei Zhang, Wilson Poon, Benjamin R. Kingston, Presley MacMillan, Abdullah Muhammad Syed, Ben Ouyang, Michael S. Valic
Publikováno v:
Nature Materials. 19:1362-1371
Nanoparticle delivery to solid tumours over the past ten years has stagnated at a median of 0.7% of the injected dose. Varying nanoparticle designs and strategies have yielded only minor improvements. Here we discovered a dose threshold for improving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b178a1492f749fb84c2c22dcef869f76
https://doi.org/10.1038/s41563-020-0755-z
https://doi.org/10.1038/s41563-020-0755-z
Publikováno v:
Nature nanotechnology. 15(10)
The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing and treating patients. Nanomaterials are promising vehicles to transport agents that include drugs, contrast agents, immunotherapies and gene editors. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e79e47b38ac7d55a3d64320e9628a7
https://pubmed.ncbi.nlm.nih.gov/32895522
https://pubmed.ncbi.nlm.nih.gov/32895522
Autor:
Pablo Llano-Suárez, Stefan Wilhelm, Warren C. W. Chan, Benjamin R. Kingston, Suresh Gadde, Abdullah Muhammad Syed, Shrey Sindhwani, Zachary Pengju Lin, Ben Ouyang, Jamie L. Y. Wu, Jessica Ngai, Zaina Kahiel, Presley MacMillan
Publikováno v:
Nano letters. 20(2)
Three-dimensional (3D) optical microscopy can be used to understand and improve the delivery of nanomedicine. However, this approach cannot be performed for analyzing liposomes in tissues because the processing step to make tissues transparent for im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea9b80dd417ebe607672e4ecdb53b19
https://pubmed.ncbi.nlm.nih.gov/31928014
https://pubmed.ncbi.nlm.nih.gov/31928014
Autor:
Warren C. W. Chan, Stefan Wilhelm, Dennis S. W. Lee, Jennifer L. Gommerman, Benjamin R. Kingston, Shrey Sindhwani, Abdullah Muhammad Syed
Publikováno v:
Journal of the American Chemical Society. 139:9961-9971
Chemical probes are key components of the bioimaging toolbox, as they label biomolecules in cells and tissues. The new challenge in bioimaging is to design chemical probes for three-dimensional (3D) tissue imaging. In this work, we discovered that li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9ec0efa4cbfe3074cc4a7d2b11fd59
https://doi.org/10.1021/jacs.7b04022
https://doi.org/10.1021/jacs.7b04022
Autor:
Anastasiya Martyts, Sean M. Kinney, Warren C. W. Chan, Benjamin R. Kingston, Michael V. Sefton, Alexander E. Vlahos, So-Yoon Won, Sara Keshavjee
Publikováno v:
Biomaterials. 232
Pancreatic islets are fragile cell clusters and many isolated islets are not suitable for transplantation. Furthermore, following transplantation, islets will experience a state of hypoxia and poor nutrient diffusion before revascularization, which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd1fb1be3fe3217f0e2eb06b3fa9483
https://pubmed.ncbi.nlm.nih.gov/31901691
https://pubmed.ncbi.nlm.nih.gov/31901691
Autor:
Ben Ouyang, Wilson Poon, Luan N. M. Nguyen, Yi-Nan Zhang, James Lazarovits, Benjamin R. Kingston, Warren C. W. Chan
Publikováno v:
Nano letters. 19(10)
Lymph node follicles capture and retain antigens to induce germinal centers and long-lived humoral immunity. However, control over antigen retention has been limited. Here we discovered that antigen conjugated to nanoparticle carriers of different si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd977b7982d1581d3a4f42da5dabfd7
https://pubmed.ncbi.nlm.nih.gov/31508968
https://pubmed.ncbi.nlm.nih.gov/31508968