Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Benjamin R Tan"'
Autor:
Laura W Goff, Nilay Thakkar, Liping Du, Emily Chan, Benjamin R Tan, Dana B Cardin, Howard L McLeod, Jordan D Berlin, Barbara Zehnbauer, Chloe Fournier, Joel Picus, Andrea Wang-Gillam, Wooin Lee, A Craig Lockhart
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107424 (2014)
Retrospective studies indicate associations between TSER (thymidylate synthase enhancer region) genotypes and clinical outcomes in patients receiving 5-FU based chemotherapy, but well-controlled prospective validation has been lacking.In this phase I
Externí odkaz:
https://doaj.org/article/a53920fb849b4a8386c051b440203a77
Autor:
Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle K. Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, Christopher A. Miller, Tanner M. Johanns, Benjamin R. Tan, Gavin P. Dunn, Timothy P. Fleming, Ted H. Hansen, S. Peter Goedegebuure, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufac
Externí odkaz:
https://doaj.org/article/031af79ff43e4bff85ce49e20a87cccb
Autor:
Paula M. Fracasso, Sherry A. Goodner, Jonathan D. Wildi, Michael J. Naughton, Gerald P. Linette, Ramaswamy Govindan, Benjamin R. Tan, Kristie A. Blum, Gary J. Jones, Tillman E. Pearce, Daniel J. Levitt, Gerald H. Clamon
Publikováno v:
Am J Clin Oncol
BACKGROUND: Human leukocyte antigen (HLA)-DR, a member of the major histocompatibility complex (MHC) class II antigen family, is a target for antibody-based therapeutics. Apolizumab (Hu1D10, Remitogen(™)), a humanized IgG1 monoclonal anti-HLA-DR ß
Autor:
Allison J. L’Hotta, Yan Yan, Andrew A. Davis, Saiama N. Waqar, Milan G. Chheda, Benjamin R. Tan, Kathleen D. Lyons, Yikyung Park, Allison A. King
Publikováno v:
Supportive Care in Cancer. 31
Autor:
Re-I Chin, Joshua P. Schiff, Anup S. Shetty, Katrina S. Pedersen, Olivia Aranha, Yi Huang, Steven R. Hunt, Sean C. Glasgow, Benjamin R. Tan, Paul E. Wise, Matthew L. Silviera, Radhika K. Smith, Rama Suresh, Kathleen Byrnes, Pamela P. Samson, Shahed N. Badiyan, Lauren E. Henke, Matthew G. Mutch, Hyun Kim
Publikováno v:
Diseases of the Colon & Rectum.
Autor:
Fady F. Youssef, MS, Parag J. Parikh, MD, Todd A. DeWees, PhD, Matthew G. Mutch, MD, Benjamin R. Tan Jr. MD, Perry W. Grigsby, MD, Robert J. Myerson, MD, PhD, Jeffrey R. Olsen, MD
Publikováno v:
Advances in Radiation Oncology, Vol 1, Iss 2, Pp 94-100 (2016)
Purpose: Locally recurrent rectal cancer may cause significant morbidity. Prior reports of rectal cancer reirradiation following local recurrence suggest treatment efficacy, with variable rates of late toxicity. Modern techniques including intensity
Externí odkaz:
https://doaj.org/article/10dd7c6d50a149019241fe9bc5ab5609
Autor:
Mateusz Opyrchal, Kian-Huat Lim, Jace Webster, Saiama N. Waqar, Albert C. Lockhart, Ningying Wu, Christopher G. Maher, Nick Boice, Joel Picus, Andrea Wang-Gillam, Benjamin R. Tan, Feng Gao, Maria Q. Baggstrom, Abhi Acharya, Daniel Morgensztern, Ramaswamy Govindan
Publikováno v:
European Journal of Cancer. 154:102-110
Aim Aurora kinase A (AURKA) is a pleiotropic serine/threonine kinase that orchestrates mitotic progression. Paclitaxel stabilises microtubules and disrupts mitotic spindle assembly. The combination of AURKA inhibitor (alisertib) plus paclitaxel may b
Autor:
Chia Jui Yen, James J. Harding, Stacey A. Cohen, Mehmet Akce, Yin Hsun Feng, Shukui Qin, Wen Tsung Huang, Imane El Dika, Ghassan K. Abou-Alfa, Tim Meyer, Dae Won Lee, Amanda Johnston, John S. Bomalaski, Debashis Sarker, Benjamin R. Tan, Baek Yeol Ryoo, Eileen M. O'Reilly, Yen Yang Chen, Ho Yeong Lim, Ching Liang Ho, Tsai Sheng Yang
Publikováno v:
Cancer. 127:4585-4593
Background Arginine starvation depletes the micronutrients required for DNA synthesis and interferes with both thymidylate synthetase activity and DNA repair pathways in preclinical models of hepatocellular carcinoma (HCC). Pegylated arginine deimina
Autor:
Albert C. Lockhart, Andrea Wang-Gillam, Michael J. Naughton, Joel Picus, Rama Suresh, Feng Gao, Gretel Terrero, Maria Q. Baggstrom, Lauren Trull, Cynthia Ma, Paula M. Fracasso, Benjamin R. Tan, Manik Amin, Stephanie Belanger
Publikováno v:
American Journal of Clinical Oncology. 44:443-448
Introduction The mammalian target of rapamycin (mTOR) is a downstream mediator in the phosphatidylinositol 3-kinase/Akt signaling pathway, and plays a central role in cell proliferation, growth, differentiation, migration, and survival. Temsirolimus
Autor:
Andrea Wang-Gillam, A. Craig Lockhart, Benjamin R. Tan, Ashley Morton, Chris Liang, Joel Picus, Bruce J. Roth, Katrina S. Pedersen, Emily Chan, Patrick M. Grierson, Jingxia Liu, Jesse Huffman
Publikováno v:
Investigational New Drugs. 39:1298-1305
Background Anti-vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) combined with mTOR inhibitors, like everolimus, result in significant responses and prolonged progression-free survival (PFS) among patients with ren